Magnetic resonance imaging with inherent local shimming

具有固有局部匀场的磁共振成像

• 批准号: 8878559
• 负责人: ALLEN W SONG
• 金额: $ 23.78万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-01 至 2017-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8878559
• 关键词: Address; Attention; Brain; Brain imaging; Brain region; Communities; Computer software; Confined Spaces; Development; Diffusion Magnetic Resonance Imaging; Electromagnetics; Emotions; Ensure; Functional Magnetic Resonance Imaging; Head; Healthcare; Human; Image; Image Analysis; Imaging Techniques; Lead; Magnetic Resonance Imaging; Manufacturer Name; Memory; Methods; Morphologic artifacts; Neurosciences; Neurosciences Research; Noise; Organ; Patients; Penetration; Performance; Population; Power Sources; Procedures; Resolution; Safety; Savings; Signal Transduction; Solutions; Systems Integration; Techniques; Technology; Testing; Tissues; Validation; base; brain research; cognitive function; contrast imaging; cost; design; diagnostic accuracy; economic impact; flexibility; imaging modality; improved; in vivo; innovation; magnetic field; neuroimaging; new technology; next generation; public health relevance; radiofrequency; research study; success

 DESCRIPTION (provided by applicant): Magnetic resonance imaging (MRI) is perhaps the most dominant imaging technique for modern neuroscience research because of its high spatial resolution, noninvasiveness, and versatile imaging contrasts. However, MRI is susceptible to main magnetic field (B0) inhomogeneities, as such virtually all MRI scanners are equipped with extensive capabilities for B0 shimming. The traditional whole-body shimming coils, which are used by all leading MRI manufacturers today, often cannot adequately correct for imaging artifacts due to high-order or local B0 inhomogenneities. These artifacts are especially apparent when fast imaging techniques are used such as in functional MRI (fMRI, used to image brain function) and diffusion tensor imaging (DTI, used to image brain connectivity). Recently proposed multi-coil local shimming strategy can perform better in the presence of high-order and local nonuniformities, however, it requires a separate array of shim coils, typically within th RF coil, to be effective and efficient, thus taking up considerable room within the already confined space for subjects. In addition, the shim array would create undesirable electromagnetic interferences and shielding effects, compromising the RF sensitivity and also reducing the flexibility and performance of the local shimming. In practice it would also require the RF coil to be enlarged, further reducing the signal-to-noise ratio (SNR). To address all these limitations and provide greatly improved B0 homogeneity without compromising any RF performance, we propose here to further develop a promising new hardware platform that enables inherent local shimming and parallel RF reception within a single unified coil array. Specifically, extending from our successful preliminary results demonstrating a 16- channel implementation, we will 1) develop and construct a 32-channel head coil array with inherent local shimming and RF reception, and 2) incorporate the newly integrated 32-channel head coil into a GE MR750 3T MRI scanner and validate the many advantages in vivo for fMRI and DTI applications. We anticipate that this new technology, inherently combining RF and shimming components within a single unified coil array, will achieve greatly improved magnetic field homogeneity and high SNR, without the need for separate sets of coils. Moreover, this innovation could be further expanded to image other organs throughout the body, thereby removing the need for whole-body shimming coils altogether and significantly widening the scanner bore to increase patient comfort and reduce manufacturing costs.

 描述（由适用提供）：磁共振成像（MRI）可能是现代神经科学研究的最主要成像技术，因为它具有高空间分辨率，无创性和多功能成像对比度。但是，MRI容易受到主磁场（B0）不均匀性的影响，因为几乎所有MRI扫描仪都具有广泛的B0弹药功能。如今，所有领先的MRI制造商都使用了传统的全身光滑线圈，通常由于高阶或局部B0不ho源性而无法充分纠正成像伪像。当使用快速成像技术（例如在功能MRI（fMRI，用于映像脑功能）和扩散张量张量成像（DTI，用于图像脑连接性）时，这些伪影尤其明显。最近提出的多圈局部弹跳策略可以在高阶和局部不均匀性的情况下表现更好，但是，它需要有效和高效的单独的垫片线圈，以便有效，因此在已经被限制的受试者空间内占据了考虑室。此外，垫片阵列将产生难以置信的电磁界面和屏蔽效果，从而损害了RF的灵敏度，并降低了局部杂物的灵活性和性能。实际上，它还需要扩大RF线圈，从而进一步降低信噪比（SNR）。为了解决所有这些局限性并提供了不大的RF性能而提供的出色改进B0同质性，我们在这里建议进一步开发一个有望的新硬件平台，该平台能够在单个统一的线圈阵列中继承本地散布和并行的RF接收。具体而言，从我们成功的初步结果中扩展了16频道实施的结果，我们将1）开发和构建一个32频道的头圈阵列阵列，并继承了本地旋转和RF接收，以及2）将新近集成的32个通道头盘组合到GE MR750 3T MRI SCANNER中，并将其用于许多Applatiation vivo和FMRRI的vivo和DTI。我们预计，这项新技术固有地将RF和光滑组件结合在单个统一的线圈阵列中，将极大地提高磁场均匀性和高SNR，而无需单独的线圈集。此外，这项创新可以进一步扩展到整个身体中的其他器官，从而完全消除了全身旋转线圈的需求，并显着扩大了扫描仪的孔，以提高患者舒适性并降低制造成本。