Magnetic resonance imaging with inherent local shimming

具有固有局部匀场的磁共振成像

• 批准号: 8878559
• 负责人: ALLEN W SONG
• 金额: $ 23.78万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-01 至 2017-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8878559
• 关键词: Address; Attention; Brain; Brain imaging; Brain region; Communities; Computer software; Confined Spaces; Development; Diffusion Magnetic Resonance Imaging; Electromagnetics; Emotions; Ensure; Functional Magnetic Resonance Imaging; Head; Healthcare; Human; Image; Image Analysis; Imaging Techniques; Lead; Magnetic Resonance Imaging; Manufacturer Name; Memory; Methods; Morphologic artifacts; Neurosciences; Neurosciences Research; Noise; Organ; Patients; Penetration; Performance; Population; Power Sources; Procedures; Resolution; Safety; Savings; Signal Transduction; Solutions; Systems Integration; Techniques; Technology; Testing; Tissues; Validation; base; brain research; cognitive function; contrast imaging; cost; design; diagnostic accuracy; economic impact; flexibility; imaging modality; improved; in vivo; innovation; magnetic field; neuroimaging; new technology; next generation; public health relevance; radiofrequency; research study; success

 DESCRIPTION (provided by applicant): Magnetic resonance imaging (MRI) is perhaps the most dominant imaging technique for modern neuroscience research because of its high spatial resolution, noninvasiveness, and versatile imaging contrasts. However, MRI is susceptible to main magnetic field (B0) inhomogeneities, as such virtually all MRI scanners are equipped with extensive capabilities for B0 shimming. The traditional whole-body shimming coils, which are used by all leading MRI manufacturers today, often cannot adequately correct for imaging artifacts due to high-order or local B0 inhomogenneities. These artifacts are especially apparent when fast imaging techniques are used such as in functional MRI (fMRI, used to image brain function) and diffusion tensor imaging (DTI, used to image brain connectivity). Recently proposed multi-coil local shimming strategy can perform better in the presence of high-order and local nonuniformities, however, it requires a separate array of shim coils, typically within th RF coil, to be effective and efficient, thus taking up considerable room within the already confined space for subjects. In addition, the shim array would create undesirable electromagnetic interferences and shielding effects, compromising the RF sensitivity and also reducing the flexibility and performance of the local shimming. In practice it would also require the RF coil to be enlarged, further reducing the signal-to-noise ratio (SNR). To address all these limitations and provide greatly improved B0 homogeneity without compromising any RF performance, we propose here to further develop a promising new hardware platform that enables inherent local shimming and parallel RF reception within a single unified coil array. Specifically, extending from our successful preliminary results demonstrating a 16- channel implementation, we will 1) develop and construct a 32-channel head coil array with inherent local shimming and RF reception, and 2) incorporate the newly integrated 32-channel head coil into a GE MR750 3T MRI scanner and validate the many advantages in vivo for fMRI and DTI applications. We anticipate that this new technology, inherently combining RF and shimming components within a single unified coil array, will achieve greatly improved magnetic field homogeneity and high SNR, without the need for separate sets of coils. Moreover, this innovation could be further expanded to image other organs throughout the body, thereby removing the need for whole-body shimming coils altogether and significantly widening the scanner bore to increase patient comfort and reduce manufacturing costs.

 描述（由申请人提供）：磁共振成像（MRI）也许是现代神经科学的最大成像技术，其高空间分辨率，非侵入性和多功能成像对比度。这样的几乎所有的MRIPUS都具有B0的广泛功能。与功能性MRI AIN功能一样）和扩散张量成像（DTI，用于脑连接的DTI）。在AL Rady的限制空间中，尖叫声会产生不良的电磁干扰，并屏蔽效果，从而使局部杂物的灵活性保持在局面Throvide大大改善了B0均质性，以损害任何RF性能，以进一步发展有前途的新硬件平台，使本地的杂物和平行的RF接收者在单个统一的线圈阵列中，从而从我们的成功前延伸。将1）带有固有的局部光盘和RF接收的El头线阵列，以及2）将新近集成的32通道头线线圈纳入GE MRI扫描仪中，并验证许多在体内和DTI应用中的优势。单个统一的线圈阵列中的光滑组件，将获得改进的磁场同质性和高SNR，而无需秘密线圈，该创新斗篷将进一步扩展到整个体内的其他器官g，需要预先体现的圆盘，并显着扩大。扫描仪钻孔到Incresse s。