An ERP Study of Number Processing and Error Detection in FAS and ADHD

FAS 和 ADHD 数字处理和错误检测的 ERP 研究

• 批准号: 8887277
• 负责人: ANDREA BERGER
• 金额: $ 17.66万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-10 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8887277
• 关键词: 10 year old; 15 year old; Adolescent; Affect; Alcohols; Anterior; Area; Arithmetic; Attention; Attention deficit hyperactivity disorder; Behavior; Behavioral; Behavioral Symptoms; Brain; Child; Cognition; Cognitive deficits; Data; Detection; Development; Diagnosis; Diagnostic; Differential Diagnosis; Disease; Etiology; Event-Related Potentials; Fetal Alcohol Exposure; Fetal Alcohol Spectrum Disorder; Fetal Alcohol Syndrome; Functional disorder; Health; Hyperactive behavior; Impairment; Incidence; Inferior; Laboratories; Lead; Mathematics; Mediating; Monitor; Neurocognitive; Parents; Parietal; Pattern; Performance; Pharmacologic Substance; Pregnancy; Process; Public Health; Reporting; Research; Site; South Africa; Specificity; System; Universities; abstracting; achievement test; alcohol consumption during pregnancy; alcohol exposure; base; brain volume; cingulate cortex; cognitive control; cohort; computerized; cost effective; design; executive function; fetal; gray matter; improved; innovation; mathematical ability; mathematical theory; neurobehavioral; neuroimaging; novel; prospective; relating to nervous system; response; selective attention; teacher; tool; white matter

DESCRIPTION (provided by applicant): Research on fetal alcohol spectrum disorder (FASD) and attention deficit hyperactivity disorder (ADHD) has been hampered by a lack of specificity in behavioral diagnostic criteria and limited understanding of the neural substrates that mediate the observed cognitive deficits. Phenotypically similar deficits seen in these disorders are difficult to distinguish despite different etiologies. Neurobehavioral data from PI Jacobson's laboratory suggest that fetal alcohol-related impairment in arithmetic is mediated by a deficit in the core quantity system involving the ability to mentally represent and manipulate number (numerosity), whereas in ADHD, poor arithmetic appears to be mediated by impaired executive function. PI Berger has developed innovative paradigms using event-related potentials (ERP) to examine the neural bases of arithmetic and attention, which make it possible to identify discrete components underlying number processing, including magnitude representation, error detection, selective attention, and response inhibition. We propose to conduct the first ERP study to compare number processing in children with and without FASD and/or ADHD to advance understanding of the neural substrates that are compromised in each of these disorders, thereby potentially improving differential diagnosis. 100 young adolescents (12.5- 15 years of age) from a well-characterized, prospective longitudinal cohort will be selected from four groups: FASD only; ADHD only; FASD + ADHD; non-exposed, unaffected controls. The aims of the study are (1) to characterize the deficits in neurocognitive processes that underlie number processing in FASD and ADHD, using a standardized mathematics achievement test and a culture-free battery based on contemporary theories of mathematical cognition; (2) to administer three ERP paradigms to examine which numerical and control processes of number processing are affected in each of these disorders-non-symbolic representation of quantity (numerosity), executive monitoring of arithmetic errors, selective attention, response inhibition/cognitive control; (3) to examine the degree to which latency and amplitude of the principal ERP waveforms that appear to be altered in FASD or ADHD are related to performance on the behavioral mathematics assessments. Exploratory analyses will also be conducted to determine the degree to which effects seen on the ERP components are specific to each of these disorders or attributable to deficits in overall intellectual and/or executive function and the degree to which total brain, gray or white matter volume, or volumes of the anterior cingulate cortex or the superior and inferior parietal region may mediate the observed effects. The proposed study will be conducted in Cape Town, South Africa, a highly cost-effective venue for this study, given the unusually large number of children with FAS available at a single site and the availability of a 128- channel Electrical Geodesics, Inc., system to acquire the ERP data.

描述（由申请人提供）：胎儿酒精谱系障碍（FASD）和注意力缺陷多动障碍（ADHD）的研究受到阻碍，这受到行为诊断标准缺乏特异性以及对介导观察到的认知缺陷的神经底物的有限理解。尽管病因不同，但在这些疾病中看到的表型相似的缺陷很难区分。来自PI Jacobson实验室的神经行为数据表明，算术中与胎儿酒精相关的障碍是由核心数量系统中的赤字介导的，涉及精神上代表和操纵数字（数字）的能力（数值），而在ADHD中，差的算术似乎是由Impair impair opair opair opair opair opair opair opair docuceive docuccoive docuceion ducveive函数介导的。 Pi Berger使用事件相关电位（ERP）开发了创新的范式，以检查算术和注意力的神经底座，这使您有可能识别数字处理的离散组件，包括幅度表示，误差检测，选择性注意力，选择性注意力和响应抑制。我们建议进行首次ERP研究，以比较有或没有FASD和/或ADHD儿童的数量处理，以提高对这些疾病中每一个中受损的神经底物的了解，从而有可能改善差异诊断。从四组中选择了100名年轻青少年（12.5-15岁），可从四组中选出一个良好的，前瞻性的纵向队列：仅FASD；只有多动症； FASD + ADHD;未暴露，未受影响的对照。该研究的目的是（1）使用标准化的数学成就测试和基于数学认知的当代理论，使用标准化的数学成就测试来表征基于FASD和ADHD的神经认知过程中的缺陷； （2）管理三个ERP范式来检查这些疾病中的每个疾病中的数值和控制过程都受到哪些数值处理的影响（数值）（数值），执行算术错误，选择性注意力，响应抑制/认知控制； （3）检验在FASD或ADHD中似乎改变的主要ERP波形的潜伏期和幅度与行为数学评估的性能有关。还将进行探索性分析，以确定对ERP组件的影响的程度，或这些疾病中的各种效果是特定的，或归因于整体智力和/或执行功能的缺陷以及总脑，灰色或白色质量，灰色或白色质量，或在前扣带扣带扣带因子或下腰corterec和下腰部区域的多数。拟议的研究将在南非开普敦进行，这是本研究的高度成本效益的场所，鉴于单个站点上有很多FA的儿童以及128-通道电气地理学公司的可用性，该系统可获取ERP数据。