Complexity Loss, Aging and the Dynamics of Frailty

复杂性丧失、衰老和脆弱的动态

基本信息

批准号：
8526311
负责人：
Madalena D Costa
金额：
$ 23.53万
依托单位：
BETH ISRAEL DEACONESS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-01 至 2015-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8526311
关键词：
Address Affect Aging American Award Biological Markers Biology of Aging Biomedical Engineering Blood Pressure Cognitive Complex Data Databases Development Elderly Equilibrium Erythrocytes Exhibits Faculty Fostering Functional disorder Funding Generic Drugs Goals Health Health Care Costs Health Status Heart Rate Human Impairment Incidence Instruction Measurement Measures Methods Morbidity - disease rate Musculoskeletal Equilibrium Nursing Homes Organ Pathologic Pathway interactions Peripheral Phase Physics Physiological Physiology Population Program Research Project Grants Property Public Health Research Research Personnel Research Training Rest Risk Series Stratification Syndrome System Testing Therapeutic Intervention Time Work base career follow-up frailty heart rhythm member mortality neuromuscular new technology novel strategies pressure programs response therapy design

项目摘要

This application constitutes the request to transition to the ROO phase of a K99 Pathway to Indepentdence Awarid aimed at fostering and expanding ail the inter-related components of a academic career in basic and applied aspects of human aging. Dr. IVladalena Costa's long-term research goals are: (i) to understand basic mechanisms of nonlinear biologic and physiologic control in health and their degradation with aging and frailty, (ii) to develop a new class of dynamical biomarkers that quantify integrative function and give information about pathophysiology not obtainable with traditional probes, and (iii) to determine the value of this new class of dynamical biomarlcers for risk stratification and the assessment of therapeutic interventions designed to reverse or retard pathologic aging. Her work is at the interfaces of statistical physics, bioengineering, physiology, and the biology of aging. Two emerging themes of this interdisciplinary work are that healthy systems, which are marked by robustness and adaptability, exhibit the most complex multiscale dynamics, and that aging and the frailty syndrome in particular, are marked by a loss of complex multiscale variability and adaptive capacity. Dr. Costa's K99 award has allowed her to become an independent investigator working at the interface between complex systems and the biologic of aging. Her specific research aims for the ROO phase as presented in the original proposal remain unchanged. Propelled by the foundational K99 training and research work. Dr. Costa is also pursuing a number of inter-related sub-projects as part of her coherent program as a full time faculty member. The specific aims are: 1) to elucidate nonlinear mechanisms of integrative physiologic control by developing dynamical biomarkers that quantify multiscale fluctuations; 2) to test the hypothesis that the dynamical complexity of physiologic regulatory mechanisms degrades with aging in representative systems ranging from the cellular to organ, and 3) to test the hypothesis that loss of complexity in physiologic systems over time can be predictive of overall health status degradation and subsequent development of frailty.

该申请构成了过渡到 K99 独立之路的 ROO 阶段的请求 Awarid 旨在培养和扩展基础和学术生涯中所有相互关联的组成部分。人类衰老的应用方面。 IVladalena Costa博士的长期研究目标是：（i）了解非线性的基本机制健康的生物和生理控制及其随着衰老和虚弱而退化，（ii）开发新的一类动态生物标志物，可量化综合功能并提供病理生理学信息传统探针无法获得，并且（iii）确定这种新的动力学类型的价值用于风险分层和评估治疗干预措施的生物标志物，旨在逆转或延缓病理性衰老。她的工作涉及统计物理学、生物工程、生理学和衰老生物学的交叉领域。二这项跨学科工作的新主题是健康的系统，其特点是稳健性和适应性，表现出最复杂的多尺度动力学，以及衰老和虚弱综合症特别是，其特点是复杂的多尺度变异性和适应能力的丧失。 Costa 博士的 K99 奖使她成为一名在界面工作的独立调查员复杂系统和衰老生物学之间的关系。她在原提案中提出的原产地规则阶段的具体研究目标保持不变。由基础性 K99 培训和研究工作推动。科斯塔博士还在追求一些作为全职教员的连贯计划的一部分，相互关联的子项目。具体目标是：1）通过发展动力学来阐明综合生理控制的非线性机制量化多尺度波动的生物标志物； 2）检验动态复杂性的假设生理调节机制随着衰老而退化，从细胞到细胞的代表性系统 3) 检验这样的假设：随着时间的推移，生理系统的复杂性会丧失预测整体健康状况恶化和随后的虚弱发展。