PURCHASE OF AN IMAGE-GUIDED SMALL-ANIMAL IRRADIATOR

购买图像引导小动物照射器

• 批准号: 8826398
• 负责人: DENNIS E HALLAHAN
• 金额: $ 59.99万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-02 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8826398
• 关键词: Animals; Biological Process; Biology; Cancer Biology; Clinical; Development; Devices; Disease; Ensure; Funding; Lead; Location; Minor; Nuclear Magnetic Resonance; Photons; Physics; Pre-Clinical Model; Radiation; Radiation Oncology; Radiobiology; Research; Research Personnel; Robotics; Safety; Specimen; Staging; System; Therapeutic Intervention; Tube; United States National Institutes of Health; Universities; Washington; X-Ray Computed Tomography; base; biological research; cancer therapy; clinical care; cone-beam computed tomography; drug development; image guided; imaging system; in vivo; instrument; instrumentation; non-invasive imaging; operation; optical imaging; pre-clinical; programs; Animals; Biological Process; Biology; Cancer Biology; Clinical; Development; Devices; Disease; Ensure; Funding; Lead; Location; Minor; Nuclear Magnetic Resonance; Photons; Physics; Pre-Clinical Model; Radiation; Radiation Oncology; Radiobiology; Research; Research Personnel; Robotics; Safety; Specimen; Staging; System; Therapeutic Intervention; Tube; United States National Institutes of Health; Universities; Washington; X-Ray Computed Tomography; base; biological research; cancer therapy; clinical care; cone-beam computed tomography; drug development; image guided; imaging system; in vivo; instrument; instrumentation; non-invasive imaging; operation; optical imaging; pre-clinical; programs

 DESCRIPTION (provided by applicant): Washington University in St. Louis has a rich tradition of radiation research and is a world leader in the field of radiation oncology for clinical care, a well as physics and biological research. Over the past twenty years, much emphasis has been placed on the development of instrumentation for the non-invasive imaging of biological processes in small animals, thereby providing investigators with a better understanding of the biology and the potential of therapeutic interventions in preclinical models. In this regard, Washington University is a recognized leader, with outstanding programs and instrumentation for preclinical magnetic resonance, nuclear, and optical imaging. Preclinical photon irradiators that can deliver radiation to precise anatomical locations in small animals are an important component of these research efforts. We therefore request funds to purchase the Xstrahl small animal radiation research platform (SARRP). Components of the SARRP include: a 225kV x- ray tube, x-ray controller, SARRP interface and PC, robotic specimen stage, safety interlock system, cone beam CT imaging system, and integrated shielding. Ten major users with NIH funding form the initial user base for the SARRP, along with three minor users. The PI has more than 25 years of expertise in clinical radiation oncology and in radiation and cancer biology research, with a primary focus is in drug development for treatment of cancer. He has assembled a strong team to oversee operations and QA of the instrument. In addition, Washington University has made a significant institutional commitment to ensure the successful use of the device after its installation. The irradiator will allow investigators to study basic questions regarding radiation research in an in vivo, pre-clinical model that will eventually lead to new paradigms in the way we treat disease in the clinical setting.

 描述（由应用程序提供）：圣路易斯的华盛顿大学具有丰富的辐射研究传统，并且是临床护理辐射肿瘤学领域的世界领导者，是物理和生物学研究。在过去的二十年中，许多重点都集中在小动物中生物学过程的非侵入性成像的仪器发展上，从而为研究人员提供了对临床前模型中的生物学和治疗性干预潜力的更好理解。在这方面，华盛顿大学是公认的领导者，具有出色的计划和仪表式临床前磁共振，核成像和光学成像。可以在小动物的精确解剖位置进行辐射的临床前光子辐照器是这些研究工作的重要组成部分。因此，我们要求资金购买Xstrahl小型动物辐射研究平台（SARRP）。 SARRP的组件包括：225kV X射线管，X射线控制器，SARRP接口和PC，机器人标本阶段，安全互锁系统，锥形束CT成像系统以及集成的屏蔽。拥有NIH资金的十个主要用户构成了SARRP的初始用户群，以及三个次要用户。 PI在临床辐射肿瘤学和辐射和癌症生物学研究方面拥有超过25年的专业知识，主要重点是用于治疗癌症的药物开发。他已经组建了一个强大的团队，并参加了该乐器的海外运营和质量检查。此外，华盛顿大学已经做出了重要的机构承诺，以确保其安装后成功使用该设备。辐照器将允许研究人员研究有关体内临床前模型中有关辐射研究的基本问题，该问题最终会导致我们在临床环境中治疗疾病的方式中产生新的范式。