Instrument and Method for Forming Three-Dimensional Ultrasound Images of the Brea

用于形成布雷亚三维超声图像的仪器和方法

• 批准号: 8711846
• 负责人: ROBERT A KRUGER
• 金额: $ 22.5万
• 依托单位: OPTOSONICS, INC.
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8711846
• 关键词: Breast; Breast Microcalcification; Data; Data Collection; Elements; Hemoglobin; Image; Imaging Device; Mammary Gland Parenchyma; Mammography; Maps; Methods; Noise; Phase; Physiologic pulse; Resolution; Sampling; Scanning; Signal Transduction; Speed; Three-Dimensional Image; Transducers; Ultrasonography; Variant; Work; base; improved; instrument; malignant breast neoplasm; photoacoustic imaging; prototype; public health relevance; reconstruction; screening; soft tissue; sound

High Definition Ultrasound for Mammography Abstract We propose to develop High Definition Ultrasound (HD-US) based on a hemispherical synthetic aperture and backscattered sonic waves. This configuration will produce direct three-dimensional maps of ultrasound reflectivity of breast tissues, and will display higher signal-to-noise, reduced speckle and greater spatial resolution compared to ultrasound arrays based on linear or curved planar sampling apertures. Our prototype hemispherical array consists of four interdigitated sub-arrays, each having 128 discrete elements. Currently, this array is used to capture 3D photoacoustic images of the whole breast using a spiral scanning strategy to increase the field of view sufficiently to perform whole-breast screening - PhotoAcoustic Mammography (PAM). In Phase I of this work, we will add a multiplexed pulser, pulse sequencer and T/R switches to capture ultrasound reflectivity data sufficient to form a 3D ultrasound image using the same reconstruction strategy used in PAM. Full 3D image acquisition will take 3.4 minutes, the same as currently used for PAM data collection. Spatial resolution and low contrast detectability will be quantified using anthropomorphic phantoms. In Phase II, HD-US will be combined with PAM to produce 3D images of soft tissue and microcalcifications. The 3D images will be co-registered with the PAM images of hemoglobin distribution in the breast using a single hemispherical transducer array.

用于乳腺 X 线摄影的高清超声 抽象的 我们建议开发基于半球形合成孔径的高清超声（HD-US） 和反向散射声波。这种配置将产生直接的三维地图 乳腺组织的超声反射率，并且将显示出更高的信噪比、减少的散斑和 与基于线性或弯曲平面采样的超声阵列相比，空间分辨率更高 孔径。 我们的原型半球形阵列由四个叉指子阵列组成，每个子阵列有 128 个离散的 元素。目前，该阵列用于捕获整个乳房的 3D 光声图像 螺旋扫描策略，足以增加视野以进行全乳腺筛查 - 光声乳腺X线摄影（PAM）。 在这项工作的第一阶段，我们将添加一个多路复用脉冲发生器、脉冲定序器和 T/R 开关来捕获 超声反射率数据足以使用相同的重建形成 3D 超声图像 PAM 中使用的策略。完整的 3D 图像采集将需要 3.4 分钟，与当前使用的相同 PAM 数据收集。空间分辨率和低对比度可检测性将使用量化 拟人化的幻影。 在第二阶段，HD-US 将与 PAM 相结合，生成软组织和图像的 3D 图像。 微钙化。 3D 图像将与血红蛋白的 PAM 图像共同配准 使用单个半球形换能器阵列在乳房中分布。