Radiation Biology of EPR Oxygen Images

EPR 氧气图像的放射生物学

• 批准号: 8825334
• 负责人: HOWARD J HALPERN
• 金额: $ 27.93万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8825334
• 关键词: Adverse effects; Animal Model; Animals; Breast Carcinoma; Caliber; Carcinoma; Data; Dose; Effectiveness; Electron Spin Resonance Spectroscopy; Electrons; Elements; Failure; Funding; Grant; Human; Hypoxia; Image; Inbred C3H Mice; Intensity-Modulated Radiotherapy; Investigation; Literature; Magnetic Resonance Imaging; Malignant Neoplasms; Mammals; Measurement; Mus; Oryctolagus cuniculus; Oxygen; Probability; Property; Radiation; Radiation therapy; Radiobiology; Rattus; Relative (related person); Reporting; Resolution; Solid Neoplasm; Specific qualifier value; Techniques; Testing; Therapeutic; Treatment Efficacy; Validation; Vascular Endothelial Growth Factors; Work; base; cancer imaging; cancer radiation therapy; efficacy testing; fibrosarcoma; improved; research study; statistics; tumor

DESCRIPTION (provided by applicant): Electron Paramagnetic Resonance (EPR) Oxygen Images (EPROI) provide quantitative localized pO2 distributions in animal tumors of syngeneic mice, rats, and rabbits. The oxygen broadening of narrow EPR spectral lines reports the pO2 with 1-3 torr resolution in each 1mm3 image voxel. This work has successfully shown 1) the first co-localized correlation between an oxygen image and a point oxygen measurement technique (Oxylite); 2) independent, statistically significant sharpening of the 50% tumor control dose with the addition of the information provided by the fraction of EPROI voxels with pO2 less than 10 torr (HF10); 3) significant spatial correlation of VEGF and EPROI based HF10; 4) when treated to the dose necessary to control 50% (TCD50) of all FSa fibrosarcomas, control is only 28% in tumors with HF10>8% while it increases to 92% for those with HF10<8%. In the next funding cycle we propose to explore EPROI as the basis for IMRT dose painting in 2cm rat 13762 carcinomas, chosen for ease of IMRT via increased size. We propose the following specific aims for the next funding cycle: exploring the effectiveness of 1) Adding a fixed dose to the TCD50 targeting an IMRT boost to an EPROI based hypoxic region, compared with adding the same boost dose to a well oxygenated tumor region of equal volume 2) Adding dose to the hypoxic region and reduced dose to a well oxygenated region. This would be compared with delivery of uniform TCD50. 3) Adding a graded dose to regions of the tumor proportional to the HF10. This work will test the efficacy of the use of oxygen imaging in dose painting in small mammals. It will provide a path to enhancement of radiation therapy efficacy and reduction of its side effects.

描述（由申请人提供）：电子顺磁共振（EPR）氧图像（EPROI）在合成小鼠，大鼠和兔子的动物肿瘤中提供定量的局部PO2分布。狭窄的EPR光谱线的氧宽扩大报告了每种1MM3图像体素中用1-3 TORR分辨率的PO2。这项工作已成功地显示了1）氧图像与点氧测量技术（Oxylite）之间的第一个共定位相关性； 2）独立的，统计学上显着的肿瘤对照剂量锐化，加上由PO2小于10 TORR的Eproi Voxel提供的信息（HF10）所提供的信息； 3）VEGF和基于EPROI的HF10的显着空间相关； 4）当对所有FSA纤维肉瘤控制50％（TCD50）所需的剂量治疗时，HF10> 8％的肿瘤中只有28％的对照，而HF10 <8％的肿瘤则增加到92％。在下一个融资周期中，我们建议探索Eproi作为2厘米大鼠13762癌的IMRT剂量绘画的基础，以增加尺寸来使IMRT易于使用。我们提出了以下针对下一个融资周期的特定目标：探索1）将固定剂量添加到靶向IMRT促进基于Eproi的低氧区域的TCD50，与将相同的增强剂量添加到相同体积的较氧化肿瘤区域相比，将剂量添加到同等体积2）为低氧区域添加剂量，并将其添加到低氧区域，并将其降低氧化型和氧化型区域。这将与均匀TCD50的交付相提并论。 3）将分级剂量添加到与HF10成比例的区域。这项工作将测试在小型哺乳动物中使用氧成像的功效。它将为增强放射疗法功效的途径和副作用降低。