Effects of Transcranial Magnetic Stimulation on Neurons in Behaving Primates

经颅磁刺激对行为灵长类动物神经元的影响

• 批准号: 8412767
• 负责人: Marc A Sommer
• 金额: $ 15.15万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8412767
• 关键词: Action Potentials; Affect; Area; Axon; Basic Science; Behavior; Behavioral; Biomedical Engineering; Brain; Cerebral cortex; Cerebrum; Cognition; Complement; Custom; Data; Distant; Electronics; Felis catus; Generations; Goals; Head; Human; Interneurons; Knowledge; Laboratories; Lateral; Location; Magnetism; Maps; Measures; Mental disorders; Methods; Modeling; Monkeys; Morphologic artifacts; Movement; Neurologic; Neurons; Outcome; Photic Stimulation; Physiologic pulse; Physiological; Primates; Protocols documentation; Pyramidal Cells; Research Personnel; Rest; Risk; Sensory Process; Series; Site; Techniques; Testing; Therapeutic; Therapeutic Intervention; Time; Transcranial magnetic stimulation; Variant; Vision; Visual; Work; area V1; area striata; awake; base; design; frontal eye fields; hippocampal pyramidal neuron; improved; in vivo; innovation; magnetic field; motor disorder; nervous system disorder; neuronal cell body; neurophysiology; nonhuman primate; oculomotor; research study; tool; visual control

Transcranial magnetic stimulation (TMS) is a non-invasive method for stimulating the human brain. It has contributed greatly to our understanding of normal brain function and shows promise in therapies for psychiatric and neurological disorders. Exactly what TMS does to neuronal activity, however, remains unknown. We will apply single pulses of TMS while recording from single neurons in behaving non-human primates. Our TMS methods will correspond to those used in humans and will be easily adoptable by any primate neurophysiology laboratory. A team of researchers will design custom TMS coils to direct the focus of stimulation to precise locations of cerebral cortex, innovative electronics to permit neuronal recordings within 1 ms after TMS pulses, and controlled visual- oculomotor tasks to allow systematic variation of behavioral and thus neuronal state. We will record from single neurons and field potentials at both the site of stimulation and at distant but monosynaptically connected sites. The end result of our work will be to discover how TMS influences the brain at the level of single neurons and simple circuits. Implications will include improved, physiologically-guided TMS protocols for human basic research studies and therapeutic applications.

经颅磁刺激（TMS）是一种刺激人脑的非侵入性方法。它 极大地促进了我们对正常大脑功能的理解，并在治疗中显示出前景 用于精神和神经系统疾病。然而，TMS 对神经元活动的作用正是如此， 仍然未知。我们将应用 TMS 的单脉冲，同时从单个神经元记录 非人类灵长类动物的行为。我们的 TMS 方法将与人类使用的方法相对应，并将 任何灵长类神经生理学实验室都可以轻松采用。一组研究人员将设计 定制 TMS 线圈将刺激焦点引导至大脑皮层的精确位置，创新 电子设备允许在 TMS 脉冲后 1 毫秒内记录神经元，并控制视觉 动眼神经任务允许行为以及神经元状态的系统变化。我们将记录 来自刺激部位和远处的单个神经元和场电位，但 单突触连接位点。我们工作的最终结果将是发现 TMS 如何影响 大脑在单个神经元和简单电路的水平上。影响将包括改进、 用于人类基础研究和治疗应用的生理引导 TMS 协议。

项目成果

Simultaneous transcranial magnetic stimulation and single-neuron recording in alert non-human primates.

在警觉的非人类灵长类动物中同时进行经颅磁刺激和单神经元记录。

• 发表时间: 2014-08
• 影响因子: 25
• 作者: Mueller, Jerel K;Grigsby, Erinn M;Prevosto, Vincent;Petraglia 3rd, Frank W;Rao, Hrishikesh;Deng, Zhi;Peterchev, Angel V;Sommer, Marc A;Egner, Tobias;Platt, Michael L;Grill, Warren M
• 通讯作者: Grill, Warren M