Development of Control Over Rewarding Stimuli: A Cognitive Neuroscience Approach

对奖励刺激的控制的发展：认知神经科学方法

• 批准号: 9189164
• 负责人: Margaret Ann Sheridan
• 金额: $ 9.59万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-02-01 至 2017-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9189164
• 关键词: Development; Control; Over; Rewarding; Stimuli

DESCRIPTION (provided by applicant): Adolescence is a period of the lifespan when challenges to behavioral regulation can have critical short and long-term repercussions including increased risk for substance abuse. To date, studies of the neural correlates of inhibitory control during this period have clear limitations and are thus poorly understood, representing a gap in knowledge with implications for a major public health concern. If we understood the mechanisms of inhibitory control, specifically in the face of rewarding stimuli, we could create more effective preventive interventions. Here we address this gap in the literature by introducing a novel test of inhibitory control over reward: Habitual Appetitive Behavior Inhibition Task (HABIT) and propose to investigate the neural correlates of the developmental progression of inhibitory control over reward in late childhood, early adolescence, late adolescence and adulthood using structural and functional magnetic resonance imaging. We further propose investigating the relationship between neural structure and function and self-reported substance use and abuse during adolescence. This task, relative to other assessments of inhibitory control, isolates deficits in adolescent cognition, relative to children that most closely aligns with the dramatic uptick in risk taking and self-reported impulsivity in adolescence

描述（由申请人提供）：青春期是一生中的一个时期，行为调节的挑战可能会产生严重的短期和长期影响，包括增加药物滥用的风险。迄今为止，对该时期抑制控制的神经相关性的研究存在明显的局限性，因此人们对其了解甚少，这代表了对重大公共卫生问题影响的知识差距。如果我们了解抑制控制的机制，特别是面对奖励刺激时的机制，我们就可以制定更有效的预防干预措施。在这里，我们通过引入一种新颖的奖励抑制控制测试来解决文献中的这一空白：习惯性食欲行为抑制任务（HABIT），并建议研究儿童晚期、青春期早期奖励抑制控制发育进程的神经相关性。青春期后期和成年期使用结构和功能磁共振成像。我们进一步建议调查神经结构和功能与青春期自我报告的药物使用和滥用之间的关系。相对于其他抑制控制评估，这项任务隔离了青少年认知缺陷，相对于与青春期冒险行为和自我报告冲动的急剧上升最密切相关的儿童

项目成果

History of conditioned reward association disrupts inhibitory control: an examination of neural correlates.

条件奖励关联的历史破坏了抑制控制：神经相关性的检查。

• DOI: 10.1016/j.neuroimage.2020.117629
• 发表时间: 2021
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Meyer,KristinN;Davidow,JulietY;VanDijk,KoeneRA;Santillana,RosarioM;Snyder,Jenna;Bustamante,ConstanzaMVidal;Hollinshead,Marissa;Rosen,BruceR;Somerville,LeahH;Sheridan,MargaretA
• 通讯作者: Sheridan,MargaretA