High-resolution in vivo and non-invasive imaging of myocardial fibers

心肌纤维的高分辨率体内和非侵入性成像

• 批准号: 8843034
• 负责人: CHUNLEI LIU
• 金额: $ 19.46万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8843034
• 关键词: Address; African American; Algorithmic Software; Algorithms; Anisotropy; Apex of the Heart; Biological; Brain; Brain imaging; Cardiac; Cardiovascular Diseases; Cause of Death; Centers for Disease Control and Prevention (U.S.); Cessation of life; Congenital Heart Defects; Detection; Diagnosis; Diffusion; Diffusion Magnetic Resonance Imaging; Early Diagnosis; Ethnic Origin; Exhibits; Fiber; Health; Heart; Heart Diseases; Hispanics; Histology; Human; Image; Imaging Techniques; Life; Magnetic Resonance Imaging; Magnetism; Maps; Measures; Mechanics; Methodology; Morus; Motion; Mus; Myocardial; Myocardium; Patients; Population; Predisposition; Preventive; Property; Research; Resolution; Speed; Structure; Techniques; Testing; Tissues; Translations; United States; Water; Woman; base; brain tissue; design; disorder prevention; heart imaging; in vivo; innovation; magnetic field; men; millimeter; non-invasive imaging; novel; prevent; white matter

DESCRIPTION (provided by applicant): One in every four deaths in the US is caused by heart disease. Heart disease is the leading cause of death for both men and women and for people of most ethnicities including African Americans, Hispanics and Whites. Besides common preventive measures, detecting early signs of cardiac abnormalities is the key for preventing death caused by heart disease. While we have a range of non-invasive MRI techniques to detect brain abnormalities, techniques for imaging the heart are still underdeveloped and often inadequate. In particular, it has been extremely challenging, if not entirely impossible, to image and track myocardial fibers in vivo. Myocardial fiber forms a unique helical spiral from base to apex of the heart. This structure is a key determinant of the mechanical and electric properties of the myocardium. While diffusion tensor imaging (DTI) has been the only technique that allows the mapping of myocardial fibers non-invasively, it has been applied primarily ex vivo. In vivo DTI of live human hearts has been only performed in a limited few studies. There are currently no clinically accepted techniques for imaging and tracking the myocardial fibers. The objective of this application is to develop and validate a radically new way to image myocardial fibers in vivo based on the technique of susceptibility tensor imaging (STI) and tractography. STI measures the interaction between magnetic fields and myocardium. It utilizes this interaction to quantify tissue property and reconstruct fiber structures. The proposed technique is fast, high resolution, non-invasive and quantitative. If successful, STI will allow the routine examination of the microstructure and connectivity of myocardium with high spatial details. It will fill in a majo gap in our capability to evaluate the myocardial conditions of both healthy and diseased hearts.

描述（由申请人提供）：美国每四个死亡中的一个死亡是由心脏病引起的。心脏病是男女死亡的主要原因，以及包括非裔美国人，西班牙裔和白人在内的大多数种族的人。除了常见的预防措施外，发现心脏异常的早期迹象是预防由心脏病引起的死亡的关键。尽管我们有一系列非侵入性MRI技术来检测脑异常，但对心脏进行成像的技术仍然欠发达且常常不足。特别是，在体内形象和跟踪心肌纤维，即使不是完全不可能，也是极具挑战性的。心肌纤维形成了从心脏的基部到顶点的独特螺旋螺旋。该结构是心肌的机械性能和电特性的关键决定因素。虽然扩散张量成像（DTI）是允许心肌纤维映射的唯一技术，但它主要是在体内应用的。在有限的少数研究中，活体内的体内DTI仅在有限的研究中进行。目前尚无用于成像和跟踪心肌纤维的临床接受技术。该应用的目的是根据易感性张量成像（STI）和拖拉术的技术来开发和验证一种彻底的新方法来在体内成像心肌纤维。 STI测量磁场与心肌之间的相互作用。它利用这种相互作用来量化组织特性并重建纤维结构。提出的技术是快速，高分辨率，无创和定量的。如果成功，STI将允许进行例行检查 高空间细节的心肌的微观结构和连通性。它将填补我们评估健康和患病心脏的心肌状况的能力。