Influence of reward on memory consolidation in adults and adolescence

奖励对成人和青少年记忆巩固的影响

基本信息

批准号：
9450704
负责人：
Vishnu Pradeep Murty
金额：
$ 23.01万
依托单位：
TEMPLE UNIV OF THE COMMONWEALTH
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-06-01 至 2021-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9450704
关键词：
Adolescence Adolescent Adult Age Alcohol or Other Drugs use Animal Model Animals Behavior Behavioral Categories Data Development Developmental Process Dopamine Drug abuse Drug usage Electroencephalography Episodic memory Esthesia Event Foundations Functional Magnetic Resonance Imaging Height Hippocampus (Brain)Hour Human Impulsivity Individual Intervention Investigation Lead Learning Literature Long-Term Potentiation Measures Mediating Memory Modality Modeling Motivation Napping Neurobiology Neurosciences Participant Pharmaceutical Preparations Population Process Research Rewards Risk Risk-Taking Rodent Rodent Model Short-Term Memory Signal Transduction Sleep Slow-Wave Sleep Substance Use Disorder Substance abuse problem Support System System Techniques Testing Time Translating Work behavioral pharmacology density dopamine system drug craving drug relapse early adolescence emerging adult long term memory memory consolidation memory encoding mesolimbic system motivated behavior multimodality neurobehavioral neurodevelopment neuroimaging neuroregulation novel relating to nervous system sensory cortex sleep spindle tool

项目摘要

Project Summary/Abstract Adolescence marks a state of increased engagement of dopamine systems, a neurobiological state associated with increased reward-motivated behaviors. While increased dopamine signaling during this time period predominately supports adaptive developmental processes, such as exploration and reward learning, it can also propel risk taking behaviors associated with substance use and abuse. Prominent animal models have shown that engagement of dopamine systems and increased reward sensitivtycan increase plasticity and consolidation in hippocampal learning systems, resulting in enhanced memory for rewarding events. Critically, these enhancements in memory underlie the reinstatement of prior drug-related contexts and propel drug use. While a large rodent literature has focused on reward’s influence on hippocampal-dependent plasticity, relatively little work has characterized these processes in human adults or adolescents. We propose to study the influence of reward on memory consolidation and episodic memory throughout adolescence into early adulthood. We will study 90 14- to 25- year-old healthy subjects using multiple neuroimaging modalities. All participants will complete a reward memory paradigm, which will allow for the quantification of the influence of reward on episodic memory, i.e. a behavioral marker of hippocampal consolidation. Memory enhancements for reward will be associated with neural markers related to memory consolidation. In Aim 1, we will characterize associations between reward-mediated memory enhancements and neural markers of consolidation in healthy adults, allowing us to translate and extend animal models into a human neuroscience framework. In Aim 2, we will characterize these relationships throughout adolescence to better understand how adolescents heighted sensitivity to reward influences long-term memory representations throughout development. This work will provide a deeper understanding of how hippocampal plasticity is influenced by reward throughout adolescence, and bolster a foundation to better understand the vulnerability to substance abuse in this population.

项目概要/摘要青春期标志着多巴胺系统参与增加的状态，这是一种与在此期间，奖励驱动行为增加。主要支持适应性发展过程，例如探索和奖励学习，它可以还推动了与药物使用和滥用相关的冒险行为。研究表明，多巴胺系统的参与和奖励敏感性的增加可以增加可塑性和巩固海马学习系统，增强对奖励事件的记忆。这些记忆的增强是恢复先前与毒品相关的环境的基础，并推动了毒品的使用。虽然大量啮齿动物文献关注奖励对海马依赖性可塑性的影响，我们建议对成人或青少年的这些过程进行研究，研究相对较少。奖励对整个青春期到早期的记忆巩固和情景记忆的影响我们将使用多种神经影像学方法研究 90 名 14 至 25 岁的健康受试者。参与者将完成奖励记忆范式，这将允许量化对情景记忆的奖励，即海马巩固记忆的行为标志。奖励将与记忆巩固相关的神经标记相关联。在目标 1 中，我们将描述其特征。奖励介导的记忆增强与健康人巩固神经标志物之间的关联成人，使我们能够将动物模型转化并扩展到人类神经科学框架中，在目标 2 中，我们。将描述整个青春期的这些关系，以更好地了解青少年如何身高对奖励的敏感性会影响整个发展过程中的长期记忆表征。更深入地了解海马可塑性如何受到奖励的影响青春期，并为更好地了解青少年中药物滥用的脆弱性奠定基础人口。