ADMINISTRATIVE CORE

行政核心

• 批准号: 8776243
• 负责人: Paul S. Aisen
• 金额: $ 174.46万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8776243
• 关键词: Adherence; Age; Aging; Alzheimer' s Disease; Biometry; Budgets; Charge; Clinical; Clinical Trials; Clinical dementia rating scale; Collaborations; Communication; Complex; Conflict of Interest; Consensus; Consent Forms; Contracts; Data; Decision Making; Development; Disclosure; Ensure; Epidemic; Ethics Committees; Evaluation; Funding; Goals; Grant; Healthcare; Housing; Human Resources; Human Subject Research; Institutional Review Boards; Leadership; Longitudinal Studies; Medical; Methods; Mission; Monitor; Multicenter Trials; Policies; Procedures; Process; Program Reviews; Protocols documentation; Regulation; Regulatory Affairs; Research; Research Infrastructure; Resource Allocation; Risk; Safety Management; Site; Source; Specimen; Suggestion; System; Training; Vendor; Vision; Work; cooperative study; data management; data sharing; design; effective therapy; experience; human subject protection; instrument; meetings; member; operation; payment; performance site; programs; quality assurance; symposium; Adherence; Age; Aging; Alzheimer' s Disease; Biometry; Budgets; Charge; Clinical; Clinical Trials; Clinical dementia rating scale; Collaborations; Communication; Complex; Conflict of Interest; Consensus; Consent Forms; Contracts; Data; Decision Making; Development; Disclosure; Ensure; Epidemic; Ethics Committees; Evaluation; Funding; Goals; Grant; Healthcare; Housing; Human Resources; Human Subject Research; Institutional Review Boards; Leadership; Longitudinal Studies; Medical; Methods; Mission; Monitor; Multicenter Trials; Policies; Procedures; Process; Program Reviews; Protocols documentation; Regulation; Regulatory Affairs; Research; Research Infrastructure; Resource Allocation; Risk; Safety Management; Site; Source; Specimen; Suggestion; System; Training; Vendor; Vision; Work; cooperative study; data management; data sharing; design; effective therapy; experience; human subject protection; instrument; meetings; member; operation; payment; performance site; programs; quality assurance; symposium

The Administrative Core (AC) serves as the central coordinating center that manages and integrates the multiple program activities carried out at the ADCS and co-located facilities, and is necessary to maintain smooth operation of this complex grant program. Because the AC activities integrate with the activities of each of the other ADCS cores and committees it results in a multi-faceted approach that lends itself to communication and information sharing among all cores. The primary objective of the AC is to provide overall direction and oversight to the ADCS by working closely with its various cores and committees to accomplish program goals. The ADCS is a large, complex organization, with over 100 members at UCSD, 8 cores, 35 primary performance sites, dozens of additional sites, multiple ongoing trials, collaborations with multiple companies, and contracts with many vendors. It is primarily an academic organization, but performs all of the activities required by multicenter trials, with an in-house data management system, biostatistics, clinical operations, regulatory oversight, medical and safety management, and onsite and remote clinical monitoring. Smooth operation requires, in addition to experience and expertise, efficient and effective management, standard operating procedures and quality assurance programs, and effective communications. The standing committees, which exist throughout the grant period, contribute to all grant activities. The Committees budgeted within the Administrative Core are the Internal Ethics Committee, the Clinical Dementia Rating Scale Committee, and the Instrument Committee with its five subcommittees.

行政核心（AC）是管理和集成在ADC和共同确定的设施进行的多个计划活动的中央协调中心，对于维持此复杂赠款计划的平稳运行是必不可少的。由于交流活动与其他ADC核心和委员会的活动相结合，因此导致了多方面的方法，可以使自己在所有核心之间进行沟通和信息共享。 AC的主要目的是通过与各种核心和委员会紧密合作以实现计划目标，从而为ADC提供总体方向和监督。 ADC是一个大型，复杂的组织，在UCSD，8个核心，35个主要绩效站点，数十个其他站点，多个正在进行的试验，与多家公司的合作以及与许多供应商的合同的合同。它主要是一个学术组织，但执行了多中心试验所需的所有活动，内部数据管理系统，生物统计学，临床操作，监管监督，医疗和安全管理以及现场和远程临床监测。平稳的操作还需要经验和专业知识，高效和有效的管理，标准操作程序和质量保证计划以及有效的沟通。在整个赠款期间存在的常设委员会为所有赠款活动做出了贡献。在行政核心内预算的委员会是内部伦理委员会，临床痴呆评级量表委员会和仪器委员会及其五个小组委员会。