The Crossroads of Lipid Metabolism and Diabetes

脂质代谢与糖尿病的十字路口

• 批准号: 8837760
• 负责人: DAVID L. WOODLAND
• 金额: $ 0.5万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-03-01 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8837760
• 关键词: Area; Atherosclerosis; Bile Acids; Biochemical; Biochemistry; Cardiovascular Diseases; Cause of Death; Cells; Cellular biology; Cholelithiasis; Cholesterol; Collaborations; Denmark; Development; Diabetes Mellitus; Discipline; Disease; Environment; Epidemic; Faculty; Fatty Acids; Gene Expression; Genetic; Goals; Heart Diseases; Hepatic; High Density Lipoprotein Cholesterol; Hypertriglyceridemia; Immunology; Incidence; Insulin Resistance; Knowledge; Lipids; Lipoproteins; Liver; Metabolic Diseases; Metabolism; Methodology; Microbiology; Molecular Biology; Molecular Genetics; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Pathway interactions; Physicians; Physiology; Postdoctoral Fellow; Prevalence; Process; Production; Research; Research Personnel; Risk Factors; Scientist; Signal Transduction; Touch sensation; Training; Transcriptional Regulation; Underrepresented Minority; abstracting; career; clinical practice; combat; diabetic patient; frontier; graduate student; lipid metabolism; liver transplantation; meetings; multidisciplinary; new therapeutic target; nonalcoholic steatohepatitis; novel; novel diagnostics; novel therapeutics; nutrition; posters; programs; public health relevance; reverse cholesterol transport; symposium; therapeutic target

 DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled The Crossroads of Lipid Metabolism and Diabetes, organized by Russell A. DeBose-Boyd, Sudha Biddinger and Alan D. Attie. The meeting will be held in Copenhagen, Denmark from April 19-24, 2015. The prevalence of Type 2 diabetes is reaching epidemic proportions throughout the world and increasing the incidence of a variety of related diseases, such as heart disease. One of the key features of these insulin-resistant disorders is disturbance of lipid metabolism. Overproduction of fatty acids in the liver leads to hypertriglyceridemia and low HDL cholesterol, which are important risk factors for the development of atherosclerosis, the most common cause of death among diabetic patients. In addition, excess fatty acid production and the accumulation of hepatic cholesterol promote the development of non-alcoholic steatohepatitis (NASH), which has become one of the leading indications for liver transplantation. Disturbances in bile acid metabolism may also contribute to the development of atherosclerosis, as well as gallstones. The goal of this Keystone Symposia meeting is to provide attendees with the latest advances in the understanding of mechanisms governing the metabolism of lipids and how these pathways become dysregulated in the insulin resistant state. Elucidation of mechanisms underlying lipid metabolism may reveal new therapeutic strategies to combat atherosclerosis and other complications of diabetic patients, such as cardiovascular disease. This program will stimulate interactions that are likely to augment and accelerate this process.

 描述（由适用提供）：请求支持Keystone研讨会会议，标题为“脂质代谢和糖尿病的十字路口”，由Russell A. Debose-Boyd，Sudha Biddinger和Alan D. Attie组织。这次会议将于2015年4月19日至24日在丹麦哥本哈根举行。2型糖尿病的患病率在全球范围内达到流行比例，并增加了多种相关疾病（例如心脏病）的发病率。这些耐胰岛素疾病的关键特征之一是脂质代谢的灾难。肝脏中脂肪酸的过量产生导致高甘油三酸酯血症和低HDL胆固醇，这是动脉粥样硬化发展的重要危险因素，这是糖尿病患者中最常见的死亡原因。此外，多余的脂肪酸产生和肝胆固醇的积累促进了非酒精性脂肪性肝炎（NASH）的发展，这已成为肝移植的主要指征之一。胆汁酸代谢的障碍也可能有助于动脉粥样硬化的发展以及仪表孔。这次Keystone研讨会会议的目的是为与会者提供了解脂质代谢的机制的最新进展，以及在抗胰岛素耐药状态下这些途径如何失调。阐明脂质代谢的机制可能揭示了对抗动脉粥样硬化和糖尿病患者（例如心血管疾病）的其他并发症的新理论策略。该程序将刺激可能增加并加速此过程的互动。