NTP Database Summarization And Evaluation

NTP数据库总结与评估

• 批准号: 8929720
• 负责人: grace e kissling
• 金额: $ 11.45万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8929720
• 关键词: Acids; Arsenic; Biological Assay; Biological Effect of Chemicals; Carcinogenicity Tests; Cells; Chemicals; Chromium; Data; Databases; Epigallocatechin Gallate; Evaluation; Genomics; Ginkgo biloba; Goals; Individual; Indole-3-Carbinol; Literature; Methods; Mus; National Toxicology Program; Paper; Publishing; Rattus; Research Design; Rodent; Statistical Methods; Test Result; Testing; Toxicity Tests; United States National Institutes of Health; base; chemical group; high throughput analysis; in vitro testing; in vivo; interest; technical report; trimethylolpropane triacrylate

We contributed to NTP technical reports of rodent bioassays on bromodichloroacetic acid, indole-3-carbinol, green tea extract and Cimstar 3800 that were reviewed by the NTP Special Emphasis Panel in April 2014. We also participated in study design committees for over 12 chemicals that will be tested by the NTP. We published papers in the scientific literature on the biological effects chemicals that were recently tested in mice and rats by the NTP: arsenic, chromium, Gingko biloba and trimethylolpropane triacrylate. We continued to provide advice on statistical methods for evaluating alternative methods for NTP's toxicity and carcinogenicity testing. These include: 1) providing advice about the analysis of high throughput data from cell-based assays of chemicals selected by the NTP, that were generated by the NIH Chemical Genomics Center, and 2) providing advice about how to combine batteries of in vitro test results to predict in vivo results.

我们为NTP生物测定的NTP技术报告做出了贡献，该报告在2014年4月由NTP Special Plaseis小组审查了NTP Special Replase Ploase审查的NTP生物测定。我们在科学文献上发表了有关生物效应化学物质的论文，这些化学物质最近在小鼠和大鼠中被NTP：砷，铬，金黄色biloba和三甲基甲基三晶。 我们继续提供有关评估NTP毒性和致癌性测试的替代方法的统计方法的建议。其中包括：1）提供有关NTP选择的化学物质的高吞吐量数据的建议，这些化学物质是由NIH化学基因组学中心产生的，以及2）提供有关如何结合体外测试的电池以预测体内结果的建议。