Multiple Myeloma Consortium Study of Occupational Exposures and Family History

多发性骨髓瘤联盟职业暴露和家族史研究

• 批准号: 8444120
• 负责人: ANNECLAIRE J DE ROOS
• 金额: $ 23.18万
• 依托单位: DREXEL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-16 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8444120
• 关键词: Acute; Address; Benzene; Biological; Carcinogens; Case-Control Studies; Classification; Code; Data; Data Set; Development; Disease; Documentation; Drug Formulations; Employment; Environment; Epidemiologic Studies; Etiology; Exposure to; Family; Family history of; Frequencies; Future; Genetic; Genetic Predisposition to Disease; Individual; Individual Adjustment; Industry; Inherited; International; Knowledge; Lymphoma; Malignant Neoplasms; Meta-Analysis; Multiple Myeloma; Myelogenous; Non-Hodgkin' s Lymphoma; Occupational; Occupational Exposure; Occupations; Organic solvent product; Population Study; Preparation; Probability; Questionnaires; Recording of previous events; Relative (related person); Research; Resources; Risk; Risk Estimate; Risk Factors; Sample Size; Solvents; Testing; Tetrachloroethylene; Toluene; Trichloroethylene; Xylene; base; cancer risk; cancer site; case control; cohort; disorder prevention; epidemiologic data; gene environment interaction; genetic variant; improved; interest; leukemia/lymphoma; public health relevance; response; trend

DESCRIPTION (provided by applicant): Exposure to solvents is widespread, both in certain occupations and in the general environment. There is a strong need for data quantifying cancer risks for suspected and known carcinogens, including trichcloroethylene (TCE) and benzene, particularly for cancer sites that are less well-described or for which the association is controversial. There are studies suggesting that these and other solvents may increase the risk of multiple myeloma (MM); however, individual, regionally-based epidemiologic studies of MM have been severely limited by the disease's rarity, hindering the ability to describe these associations with confidence. Much larger numbers are needed to study occupational solvent exposures, particularly to characterize risks across varying exposure intensity levels or with increasing duration. With an efficient approach of combining existing MM epidemiologic data resources for collaborative reanalyses, we will pool data from 13 case-control studies participating in the International Multiple Myeloma Consortium (IMMC) to conduct the most powerful study to date of risks associated with occupational solvent exposures. Completed studies participating in the IMMC include over 3600 cases and 12,000 controls with questionnaire data on occupation (e.g., job title/industry with- or without additional questions on tasks and exposures), and based on these data we will assess exposure to five specific solvents of particular interest: trichloroethylene (TCE), perchloroethylene (PCE), benzene, toluene, and xylene. Family history of lymphohematopoietic cancers is also important to harmonize across IMMC studies as it is a likely risk factor for MM and therefore a critical factor to consider as a potential confounder or effect modifier (as an indicator of inherited susceptibiliy to develop MM) of occupational or other exposures. For example, we will explore interactions between occupational solvent exposures and family history of these cancers in development of MM, an interaction that has been suggested for non-Hodgkin lymphoma, and which may indicate an interaction between genetic variants and solvent exposure in lymphoma etiology. The IMMC is the best (and perhaps the only) current setting to address our study aims, not only because of the study size, but because the participating case-control studies collected occupational and family histories with a level of detail that isn't matched in typical cohort studis. Our effort in coding and harmonizing variables across participating studies will develop a valuable resource for future consortium studies of other occupational exposures, genetic variants associated with familial- versus non- familial MM, and gene-environment interactions.

描述（由申请人提供）：在某些职业和一般环境中，接触溶剂是很普遍的。迫切需要量化可疑和已知致癌物（包括三氯乙烯（TCE）和苯）的癌症风险的数据，特别是对于描述不太清楚或相关性存在争议的癌症部位。有研究表明这些溶剂和其他溶剂可能会增加患多发性骨髓瘤 (MM) 的风险；然而，MM 的个别、区域性流行病学研究由于该疾病的罕见性而受到严重限制，从而妨碍了自信地描述这些关联的能力。研究职业溶剂暴露需要更多的数据，特别是描述不同暴露强度水平或持续时间增加的风险。通过结合现有多发性骨髓瘤流行病学数据资源进行协作再分析的有效方法，我们将汇集参与国际多发性骨髓瘤联盟 (IMMC) 的 13 项病例对照研究的数据，以开展迄今为止最有力的与职业溶剂接触相关风险的研究。参与 IMMC 的已完成研究包括超过 3600 个案例和 12,000 个对照，其中包含有关职业的问卷数据（例如，职位/行业，有或没有关于职业的附加问题） 任务和暴露），并根据这些数据，我们将评估五种特别感兴趣的特定溶剂的暴露：三氯乙烯（TCE）、全氯乙烯（PCE）、苯、甲苯和二甲苯。淋巴造血系统癌症家族史对于协调 IMMC 研究也很重要，因为它是 MM 的可能危险因素，因此是考虑作为职业或职业或疾病的潜在混杂因素或效应调节剂（作为发展 MM 遗传易感性的指标）的关键因素。其他暴露。例如，我们将探讨职业性溶剂暴露与这些癌症家族史在 MM 发展过程中的相互作用，这种相互作用已被认为适用于非霍奇金淋巴瘤，并且可能表明遗传变异与淋巴瘤病因学中溶剂暴露之间的相互作用。 IMMC 是目前解决我们研究目标的最佳（也许是唯一）环境，不仅因为研究规模，还因为参与的病例对照研究收集了职业史和家族史，其详细程度不匹配在典型的队列研究中。我们在参与研究中编码和协调变量的努力将为未来其他职业暴露、与家族性与非家族性多发性骨髓瘤相关的遗传变异以及基因-环境相互作用的联合研究开发宝贵的资源。