Social Sensitivity and Depression in Peer-Victimized Girls: Insights from Neuroscience

受同伴伤害的女孩的社会敏感性和抑郁症：来自神经科学的见解

• 批准号: 8969551
• 负责人: KAREN D RUDOLPH
• 金额: $ 7.93万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8969551
• 关键词: Accounting; Address; Adolescence; Adolescent; Adult; Adverse effects; Amygdaloid structure; Attenuated; Behavioral; Brain; Brain region; Buffers; Childhood; Chronic; Clinical; Cues; Data; Data Set; Depression and Suicide; Development; Emotional; Emotional Disturbance; Emotional disorder; Emotions; Event; Experimental Designs; Exposure to; Family health status; Female Adolescents; Future; Goals; Health; Individual; Individual Differences; Insula of Reil; Investigation; Knowledge; Laboratories; Life; Life Stress; Link; Longitudinal Studies; Mediating; Mental Depression; Mental Health; Mental disorders; Methods; Motivation; National Institute of Mental Health; Negative Valence; Neurosciences; Outcome; Pain; Pathway interactions; Performance; Personal Satisfaction; Policies; Positioning Attribute; Practice Guidelines; Prefrontal Cortex; Prevalence; Prevention; Prevention program; Preventive Intervention; Process; Psychopathology; Public Health; Recording of previous events; Regulation; Relative (related person); Research; Research Design; Research Domain Criteria; Resources; Risk; Sampling; Scientist; Shapes; Skin; Social Psychology; Societies; Staging; Stress; System; Time; Victimization; Youth; adverse outcome; affective neuroscience; attentional bias; base; biological adaptation to stress; child depression; chronic depression; cost; depressive symptoms; design; developmental psychology; eleventh grade; girls; innovation; insight; intervention program; neuroregulation; ninth grade; novel; peer; peer victimization; policy implication; prevent; prospective; public health relevance; recurrent depression; relating to nervous system; resilience; second grade; social; social stress; stress reactivity; stressor; theories; Accounting; Address; Adolescence; Adolescent; Adult; Adverse effects; Amygdaloid structure; Attenuated; Behavioral; Brain; Brain region; Buffers; Childhood; Chronic; Clinical; Cues; Data; Data Set; Depression and Suicide; Development; Emotional; Emotional Disturbance; Emotional disorder; Emotions; Event; Experimental Designs; Exposure to; Family health status; Female Adolescents; Future; Goals; Health; Individual; Individual Differences; Insula of Reil; Investigation; Knowledge; Laboratories; Life; Life Stress; Link; Longitudinal Studies; Mediating; Mental Depression; Mental Health; Mental disorders; Methods; Motivation; National Institute of Mental Health; Negative Valence; Neurosciences; Outcome; Pain; Pathway interactions; Performance; Personal Satisfaction; Policies; Positioning Attribute; Practice Guidelines; Prefrontal Cortex; Prevalence; Prevention; Prevention program; Preventive Intervention; Process; Psychopathology; Public Health; Recording of previous events; Regulation; Relative (related person); Research; Research Design; Research Domain Criteria; Resources; Risk; Sampling; Scientist; Shapes; Skin; Social Psychology; Societies; Staging; Stress; System; Time; Victimization; Youth; adverse outcome; affective neuroscience; attentional bias; base; biological adaptation to stress; child depression; chronic depression; cost; depressive symptoms; design; developmental psychology; eleventh grade; girls; innovation; insight; intervention program; neuroregulation; ninth grade; novel; peer; peer victimization; policy implication; prevent; prospective; public health relevance; recurrent depression; relating to nervous system; resilience; second grade; social; social stress; stress reactivity; stressor; theories

 DESCRIPTION (provided by applicant): Peer victimization is a salient form of early adversity with long-term costs for youths' mental health. Indeed, research and media coverage place peer victimization on the national agenda as a critical public health issue, given its prevalence and it implications for emotional well-being into adolescence and adulthood. Identifying processes accounting for these enduring effects is critical for informing policy and practice, yet scientists have not yet discovered the processes through which victimization derails youths' development-that is, how victimization "gets under the skin" in ways that instill long-term risk. Inspired by a growing recognition of the pervasive impact of early life stress on maturing brain systems and associated psychopathology, this research will contribute substantially to scientific knowledge and its application by documenting the adolescent sequelae of victimization, with broader implications for enriching our understanding of the mechanisms through which early adversity shapes stress reactivity and mental health. Integrating ideas across the fields of developmental and social psychology, social affective neuroscience, and developmental psychopathology with the NIMH RDoC framework, this research will examine whether victimization is linked to dysregulated negative valence systems involved in sustained threat/loss, thereby heightening reactivity and compromising regulation and contributing to adolescent depression. Introducing an innovative methodological approach into the field of peer victimization, this research will use a multi-level design, examining reactivity and regulation at both the neural and behavioral levels in the context of an experimental design (laboratory cues of social threat/loss). This study will take advantage of an existing sample of adolescent girls (10th-11th graders), well-characterized on victimization, individual differences in risks and resources, and mental health from 2nd-9th grade, thereby providing the opportunity to leverage a comprehensive longitudinal data set to enrich the proposed short-term (two-year) investigation of neural/behavioral processing and depressive symptoms. Thus, this study is uniquely positioned to examine the link between childhood victimization and subsequent neural and behavioral processing of social cues as well as to determine whether stress reactivity/regulation account for the contribution of victimization to adolescent depression. This research also will provide novel data on individual differences in risk and resilience processes, thereby maximizing the efficiency of prevention/intervention programs. Ultimately, it is anticipated that this researc will serve as a basis for larger longitudinal studies investigating: (a) how early adversity withina variety of contexts influences emerging brain systems in ways that set the stage for adolescent mental health problems; and (b) individual and contextual resources that may buffer youth against these adverse consequences. This line of research can yield clear and compelling implications for policy and practice guidelines aimed at minimizing the threat posed by early social adversity to youths' health and development, with potential implications for long-term adaptation and societal burden.

 描述（由应用程序提供）：同伴胜利是早期广告的一种显着形式，为青年人的心理健康带来了长期成本。的确，鉴于其流行率及其对情感幸福感，因此，研究和媒体报道将同伴胜利视为一个关键的公共卫生问题。确定对这些持久影响的过程对于为政策和实践提供信息至关重要，但科学家 尚未发现胜利使年轻人发展的过程，即胜利如何以灌输长期风险的方式“在皮肤下”。这项研究受到对早期生活压力对成熟脑系统和相关心理病理学的普遍影响的普遍影响的启发，这项研究将通过记录胜利的青少年序列，从而对科学知识及其应用产生重大贡献，这对我们对早期广告的理解具有更广泛的影响，从而增强了我们对早期广告的理解。将发展和社会心理学，社会情感神经科学以及发展心理病理学的思想与NIMH RDOC框架整合在一起，这项研究将检查胜利是否与持续威胁/丧失的负面价系统相关联，从而增加了反应性和损害的反应性和对青少年抑郁症的损害。这项研究将在同伴胜利的领域中引入创新的方法论方法，在实验设计的背景下（社会威胁/损失的实验室提示），在神经元和行为水平上检查了反应性和调节。这项研究将利用现有的青春期女孩样本（10年级学生），对冒险，风险和资源的个体差异以及二年级的精神健康进行了充分的表征，从而提供了利用全面的纵向数据设定的机会，以丰富提议的短期（两年（两年）的神经/行为行为处理和抑郁症状症状。这是唯一的定位，可以检查儿童胜利与随后的社会线索中性和行为处理之间的联系，并确定压力反应性/调节是否解释了胜利对青少年抑郁症的贡献。这项研究还将提供有关风险和弹性过程中个体差异的新数据，从而最大程度地提高了预防/干预计划的效率。最终，可以预料，这种恢复将成为更大的纵向研究的基础：（a）各种环境内的早期广告如何以为青少年心理健康问题奠定基础的方式影响新兴的大脑系统； （b）可能使青年免受这些不利后果的个人和上下文资源。这项研究可以产生对政策和实践指南的明确和令人信服的影响，旨在最大程度地减少早期社会广告对青年人健康和发展的威胁，并可能对长期适应和社会伯恩（Social Burnen）产生影响。