Continued studies of environment impact on puberty

环境对青春期影响的持续研究

• 批准号: 9135611
• 负责人: FRANK M BIRO
• 金额: $ 12.09万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9135611
• 关键词: Adopted; Adult; Age; Age at Menarche; Behavior; Benchmarking; Biological Phenomena; Body Composition; Body fat; Breast; Community Outreach; Deposition; Development; Dietary intake; Dimensions; Endocrine Disruptors; Endocrine disruption; Energy Intake; Environment; Environmental Exposure; Environmental Risk Factor; Epidemiology; Exposure to; Family Study; Fatty acid glycerol esters; Future; Genes; Genetic Polymorphism; Gonadal Steroid Hormones; Growth; Health; Height; Individual; Insulin Resistance; Knowledge; Life Style; Link; Mammary Gland Parenchyma; Mediating; Menarche; Minerals; Morbidity - disease rate; Obesity; Outcome; Participant; Pathway interactions; Physical activity; Phytoestrogens; Predisposition; Prevalence; Prevention strategy; Principal Investigator; Production; Protocols documentation; Puberty; Reporting; Risk; Series; Social Environment; Stress; Teenagers; Time; Toxic Environmental Substances; Visceral; Woman; Work; bone; chemical genetics; cohort; environmental chemical; evidence base; genetic variant; girls; high school; lipid metabolism; malignant breast neoplasm; mortality; obesity risk; outreach program; phthalates; toxicant

DESCRIPTION (provided by applicant): Puberty may serve as a window of susceptibility that impacts adult morbidity and mortality, and peripubertal breast tissue may be especially susceptible to environmental exposures. The majority of bone mineral is deposited during teen years, and insulin resistance rises during puberty. Visceral fat is an important factor that increases risk of obesity complications, but little is known about early factors that impact deposition of visceral fat Environmental exposures may impact body composition, as well as pubertal outcomes. Age at menarche is associated with risk of breast cancer, but pubertal growth velocity may be the underlying biologic phenomenon that impacts greater risk of breast cancer in taller women and those with earlier menarche. We will utilize a unique existing cohort of girls followed from ages 6 and 7 and who have had semiannual examinations over 3-5 years. Working closely with the other two BCERC epidemiology projects, and with the Cincinnati BCERC community outreach program, our study proposes to fill the gap towards understanding the relationships between timing of onset and pathway of puberty with menarche, interaction between endocrine disruptors and polymorphisms, and changes in body composition. We will complete the maturation assessment in this established cohort of girls, to include age at menarche, tempo of maturation, age/value of peak height velocity, body composition and fat distribution, and bone mineral accrual during puberty, by pathway into puberty. We plan to assess dimensions of the physical/social environments including exposures to endocrine disrupting toxicants (EDCs), and how these factors contribute to impact onset of puberty and menarche. We will explore the relationships and interactions of EDCs and genetic polymorphisms, on benchmarks of pubertal maturation. The Cincinnati epidemiology and outreach programs will develop and disseminate materials for lay audiences about lifestyle choices and potential health risks of specific exposures in regard to breast cancer, and enhance protocols to report study findings to study families. This proposal should allow us to understand better how changes during puberty can inform future prevention strategies to decrease the prevalence of breast cancer.

描述（由申请人提供）：青春期可以用作影响成人发病率和死亡率的敏感性窗口，而perip骨乳房组织可能特别容易受到环境暴露的影响。大多数骨矿物质是在青少年时期沉积的，青春期期间胰岛素抵抗会增加。内脏脂肪是增加肥胖风险的重要因素，但是对影响内脏脂肪环境暴露沉积的早期因素几乎不知所为，可能会影响人体成分以及青春期的结果。初潮的年龄与患乳腺癌的风险有关，但是青春期的生长速度可能是潜在的生物学现象，它会影响较高的女性和患有早期初潮的较高女性的乳腺癌风险更大。我们将利用一个独特的现有女孩，然后是6岁和7岁的女孩，并在3 - 5年内进行了半年度考试。我们的研究与其他两个BCERC流行病学项目紧密合作，并与辛辛那提BCERC社区外展计划合作，我们的研究建议填补了解青春期的时间与初潮的相互作用，内分泌干扰物与多态性的相互作用以及身体成分的变化之间的差距。我们将完成这一既定女孩的成熟评估，包括初潮的年龄，成熟的速度，峰高速度的年龄/价值，人体成分和脂肪分布以及青春期期间的骨矿物质累积，并通过进入青春期的途径。我们计划评估物理/社会环境的维度，包括暴露于内分泌破坏有毒物质（EDC），以及这些因素如何影响青春期和初潮的发作。我们将探讨EDC和遗传多态性的关系和相互作用，对青春期成熟的基准。辛辛那提的流行病学和外展计划将开发和传播有关生活方式选择和有关乳腺癌特定暴露的潜在健康风险的材料，并增强对研究家庭的研究结果的协议。该提案应该使我们能够更好地了解青春期的变化如何能够为未来的预防策略提供信息，从而降低乳腺癌的患病率。