6/6-Child/Adolescent Anxiety Multimodal Extended Long-Term Study (CAMELS)

6/6 儿童/青少年焦虑多模式扩展长期研究 (CAMELS)

• 批准号: 8650922
• 负责人: John C. Piacentini
• 金额: $ 10.56万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8650922
• 关键词: Academic Medical Centers; Acute; Address; Adherence; Adolescent; Adverse effects; Affect; Alcohol or Other Drugs use; Anxiety; Anxiety Disorders; Benchmarking; Biometry; Budgets; California; Child; Childhood; Chronic; Clinic; Clinical; Clinical Research; Cognition; Cognitive Therapy; Collaborations; Communication; Consensus; Data; Data Analyses; Data Set; Development; Diagnosis; Diagnostic; Discipline; Disease; Distal; Early treatment; Enrollment; Ethnic Origin; Feeling suicidal; Fright; Generalized Anxiety Disorder; Goals; Grant; Growth and Development function; Guidelines; Impairment; Individual; Institutes; Intervention; Interview; Journals; Lead; Letters; Light; Longitudinal Studies; Los Angeles; Maintenance; Manuscripts; Measures; Mediator of activation protein; Medical; Medicine; Mental Depression; Mental Health; Mental Health Services; Mental disorders; Methods; Modeling; Monitor; National Institute of Mental Health; New England; New York; Newsletter; Paper; Parents; Participant; Pattern; Persons; Pharmaceutical Preparations; Phase; Physical Function; Placebos; Preparation; Prevalence; Prevention; Preventive; Procedures; Protocols documentation; Psychiatrist; Psychologist; Psychopathology; Public Health; Publications; Publishing; Random Allocation; Randomized; Records; Recruitment Activity; Relapse; Relative (related person); Research; Research Infrastructure; Research Personnel; Risk; Role; Rural; Sampling; Sampling Studies; Selective Serotonin Reuptake Inhibitor; Separation Anxiety Disorder; Sertraline; Services; Severity of illness; Site; Social Phobia; Structure; Substance Use Disorder; Symptoms; Teleconferences; Telephone; Time; Training; Universities; Voting; Work; Youth; cost; data management; depressive symptoms; effective intervention; effective therapy; experience; follow-up; functional outcomes; human subject; interest; meetings; member; multi-site trial; multidisciplinary; operation; pill; prevent; primary outcome; psychologic; psychosocial; public health relevance; quality assurance; response; service utilization; social; suicidal behavior; symposium; synergism; teacher; treatment effect; treatment trial; vigilance; willingness

DESCRIPTION (provided by applicant): Anxiety disorders are the most common psychiatric illnesses in youth with prevalence rates averaging 5-20%. These disorders are associated with significant short- and long-term impairment in academic, familial, social, and psychological functioning. Although medication and cognitive-behavioral therapy (CBT) have been found to be effective in the short term, questions remain regarding the durability of treatment effects and the relative impact of intervention on long-term functioning. This competing continuation application (in response to PAR- 09-153) will continue the successful multi-site collaboration of the Child/Adolescent Anxiety Multi-modal Study (CAMS) group to conduct a 5-year follow-up of the sample of youth with anxiety disorders that participated in the CAMS trial. The six sites are: New York State Psychiatric Institute; Duke University Medical Center; Johns Hopkins University; Temple University; University of California at Los Angeles; and Western Psychiatric Institute and Clinic. The central questions of the proposed study, entitled the Child/Adolescent Anxiety Multimodal Extended Long-term Study (CAMELS), are to examine the long-term psychiatric, physical, and functional outcomes of youth with anxiety disorders who were randomized to one of four treatment conditions (i.e., CBT, sertraline [SRT], pill placebo, or combined CBT + SRT). CAMS succeeded in randomizing 488 children/adolescents. The CAMELS is critical in light of the need for additional information about the effects of successful treatment on the course of anxiety symptoms and their sequelae and the NIMH priority to understand the developmental trajectories of mental illness (US DHHS, 2008). CAMELS will enroll the largest sample of carefully characterized youth with anxiety disorders and will inform the field about: 1) the preventive effects of successful treatment (psychosocial; medication) on the development of later psychopathology, 2) treatment durability, 3) potential long-term adverse effects (e.g., from chronic use of medication), and 4) predictors of relapse or long-term maintenance. Findings will also be used to refine current treatments, shedding light on how existing interventions may need to be augmented or personalized to target specific distal psychopathology and/or functional outcomes for specific children.

描述（由申请人提供）：焦虑症是平均患病率为5-20％的年轻人中最常见的精神病。这些疾病与学术，家族，社会和心理功能的重大短期和长期障碍有关。尽管已经发现药物和认知行为疗法（CBT）在短期内有效，但有关治疗效果的持久性以及干预对长期功能的相对影响仍然存在的问题。这种竞争性的连续性应用程序（响应于09-153 par）将继续进行儿童/青少年焦虑多模式研究（CAMS）小组的成功多站点合作，以对参加CAMS试验的焦虑症青年样本进行5年的随访。这六个地点是：纽约州精神病学院；杜克大学医学中心；约翰·霍普金斯大学；庙宇大学;加州大学洛杉矶分校；以及西方精神病学院和诊所。这项拟议的研究的核心问题，题为“儿童/青春期焦虑多模式的长期研究（骆驼）”是为了检查患有焦虑症的青年的长期精神，身体和功能性结果，这些年轻人被随机分为四种治疗条件之一（即CBT，CBT，Sertraline，srtraline [srt]，Pill pillt sperbo，pill pillt splobo，pill coltbo cobt + sbt + srt + srt + srt + srt）。凸轮成功将488名儿童/青少年随机分配。鉴于需要有关成功治疗对焦虑症状及其后遗症以及NIMH优先事项的影响的其他信息，骆驼至关重要（US DHHS，2008年）。骆驼将在焦虑症的精心表征的年轻人中招收最大的样本，并将告知该领域：1）成功治疗（心理社会；药物）对后来的心理病理学发展的预防作用，2）2）治疗耐用性，3）潜在的长期不良影响（例如，药物的持续性使用），以及4）预测相对于复发或长期维持的预测者。调查结果还将用于完善当前的治疗方法，阐明如何增加或个性化现有干预措施，以针对特定儿童的特定远端心理病理学和/或功能结果。