Project 1

项目1

• 批准号: 8933165
• 负责人: BLOSSOM A DAMANIA
• 金额: $ 8.1万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-15 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8933165
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Africa South of the Sahara; Anti-Retroviral Agents; Cancer Burden; Cancer Control; Caring; Clinic; Clinical Research; Collaborations; Data; Data Linkages; Data Quality; Data Set; Databases; Diagnosis; Doctor of Philosophy; Ensure; Epidemic; Epidemiologic Studies; Epidemiology; Flowers; Frequencies; General Population; Goals; HIV; Health; Herpesviridae; Hospitals; Incidence; Individual; International; Kaposi Sarcoma; Link; Lymphoma; Malawi; Malignant Neoplasms; Measures; Medicine; Methods; Monitor; Monograph; North Carolina; Patients; Persons; Population; Prevention; Principal Investigator; Registries; Research; Research Infrastructure; Research Project Grants; Resources; Risk; Risk Factors; Running; South Africa; System; Time; Trust; Universities; Update; Work; antiretroviral therapy; base; cancer risk; cohort; college; follow-up; geographic population; implementation science; neoplasm registry; population based; professor; scale up; success; trend; tumor; virology

This application is to establish the UNC-Malawi Cancer Consortium (UNC-MCC), to develop capacity and conduct high-impact research focused on HIV-associated cancers. The consortium builds on longstanding collaborations between the University of North Carolina at Chapel Hill.(UNC-CH), Lighthouse Trust, Malawi Ministry of Health, and University of Malawi College of Medicine. These partnerships have resulted in internationally recognized contributions for HIV care and prevention in sub-Saharan Africa. This infrastructure can now be leveraged for HIV-associated malignancies. UNC-MCC is focused on the herpesvirus-associated cancers, Kaposi sarcoma (KS), and lymphoma. Our consortium will be led by three principal investigators with highly complementary expertise (Satish Gopal MD, clinical research; Sam Phiri PhD, implementation science; Blossom Damania PhD, virology). The first of three research projects being undertaken by UNC-MCC is an HIV-cancer record linkage study using the Malawi National Cancer Registry (MNCR). The project is led by three co-PIs, Drs. Charles Dzamalala (MNCR Director), Kennedy Malisita (Director, Antiretroviral Therapy Clinic, Queen Elizabeth Central Hospital), and Andy Olshan (Professor and Chair of the UNC-CH Department of Epidemiology). The project utilizes a unique set of resources within Malawi, including a population-based national cancer registry which is one of only four from sub-Saharan Africa to be included in the current WHO cancer incidence monograph, and HIV cohorts with detailed, longitudinal characterization of large numbers of patients. Combining these resources presents a rare opportunity to understand how cancer risk may be changing in the antiretroviral (ART) therapy, including for herpesvirus-associated cancers. This is still largely unknown in sub-Saharan Africa, and declines in incidence have not yet been observed in Malawi even after ART scale-up began 2004. The study will be conducted using probabilistic matching methods to link large national datasets, with technical assistance from the International Epidemiologic Databases to Evaluate AIDS (IeDEA) network, who have sponsored prior record linkage studies in South Africa. This work is anticipated to result in one of the best epidemiologic resources in the region for HIV-related malignancies research, to better understand current trends, and assist in prioritization of resources within Malawi based on high-quality local data.

该应用是为了建立UNC-Malawi癌症联盟（UNC-MCC），以发展能力并进行针对HIV相关癌症的高影响力研究。该财团建立在北卡罗来纳大学教堂山分校（UNC-CH），灯塔信托基金，马拉维卫生部和马拉维大学医学院之间的长期合作。这些伙伴关系为撒哈拉以南非洲提供了国际认可的艾滋病毒护理和预防贡献。现在，可以利用这种基础设施来用于与HIV相关的恶性肿瘤。 UNC-MCC专注于与疱疹病毒相关的癌症，Kaposi肉瘤（KS）和淋巴瘤。我们的财团将由三位具有高度互补专业知识的主要研究人员（Satish Gopal MD，临床研究； Sam Phiri博士，实施科学； Blossom Damania Phd，病毒学）。 UNC-MCC正在进行的三个研究项目中的第一个是使用马拉维国家癌症注册中心（MNCR）进行的HIV-CACCER记录联系研究。该项目由三个共同案例领导。 Charles Dzamalala（MNCR主任），肯尼迪·马里西塔（Kennedy Malisita）（伊丽莎白女王中央医院的抗逆转录病毒疗法诊所主任）和安迪·奥尔山（Andy Olshan）（UNC-CH流行病学系教授兼主席）。该项目利用马拉维境内的一套独特的资源，包括基于人群的国家癌症注册中心，这是撒哈拉以南非洲次数的四个资源之一，其中包括当前的WHO癌症发病率专着，艾滋病毒队列具有大量患者的详细纵向表征。结合这些资源是一个难得的机会，可以理解抗逆转录病毒（ART）疗法的癌症风险如何改变，包括与疱疹病毒相关的癌症。在撒哈拉以南非洲，这仍然是未知的，即使在2004年开始艺术扩展之后，马拉维仍未观察到发病率下降。这项研究将使用概率匹配的方法来链接大型国家数据集，并在国际流行病学数据库（IEDEA）网络（IEDEA）网络（IEDEA）网络（IEDEA）网络中链接大型国家数据集，这些人已经有了Spessore nistan nords nickage nickage nickage nickage。预计这项工作将导致该地区与HIV相关的恶性肿瘤研究中最佳的流行病学资源之一，以更好地了解当前趋势，并根据高质量的本地数据帮助马拉维内部资源的优先级。