Sleep apnea health disparities in Mexican American stroke patients

墨西哥裔美国中风患者的睡眠呼吸暂停健康差异

• 批准号: 8836598
• 负责人: DEVIN L BROWN
• 金额: $ 61.96万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8836598
• 关键词: Academic Medical Centers; Accounting; Acute; Admixture; Adult; Age; American; Cardiopulmonary; Caring; Cause of Death; Cerebral hemisphere hemorrhage; Cognitive; County; Data; Data Collection; Devices; Disease; Education; Environmental Risk Factor; Epidemiology; European; Event; Frequencies; Future; Genes; Genetic; Genetic Determinism; Genetic study; Goals; Health; Health Professional; Health Services; Health Services Accessibility; High Prevalence; Hispanic Americans; Hispanics; Impairment; Inherited; Intervention; Interview; Investigation; Ischemic Stroke; Laboratories; Life Style; Link; Measures; Methods; Mexican Americans; Minority; Minority Groups; Neurologic; Obesity; Outcome; Parents; Patients; Population; Population Heterogeneity; Preparation; Prevalence; Provider; Publishing; Quality of life; Questionnaires; Recurrence; Research; Research Infrastructure; Research Personnel; Risk; Risk Factors; Severities; Sleep; Sleep Apnea Syndromes; Smoking; Stroke; Subgroup; Symptoms; Testing; Texas; United States; acute stroke; cognitive function; cost; cost effective; disability; early onset; ethnic difference; experience; functional outcomes; genetic risk factor; health disparity; high risk; improved; innovation; lifestyle factors; mortality; novel; population based; post stroke; prevent; screening; social; surveillance study; therapy development; Academic Medical Centers; Accounting; Acute; Admixture; Adult; Age; American; Cardiopulmonary; Caring; Cause of Death; Cerebral hemisphere hemorrhage; Cognitive; County; Data; Data Collection; Devices; Disease; Education; Environmental Risk Factor; Epidemiology; European; Event; Frequencies; Future; Genes; Genetic; Genetic Determinism; Genetic study; Goals; Health; Health Professional; Health Services; Health Services Accessibility; High Prevalence; Hispanic Americans; Hispanics; Impairment; Inherited; Intervention; Interview; Investigation; Ischemic Stroke; Laboratories; Life Style; Link; Measures; Methods; Mexican Americans; Minority; Minority Groups; Neurologic; Obesity; Outcome; Parents; Patients; Population; Population Heterogeneity; Preparation; Prevalence; Provider; Publishing; Quality of life; Questionnaires; Recurrence; Research; Research Infrastructure; Research Personnel; Risk; Risk Factors; Severities; Sleep; Sleep Apnea Syndromes; Smoking; Stroke; Subgroup; Symptoms; Testing; Texas; United States; acute stroke; cognitive function; cost; cost effective; disability; early onset; ethnic difference; experience; functional outcomes; genetic risk factor; health disparity; high risk; improved; innovation; lifestyle factors; mortality; novel; population based; post stroke; prevent; screening; social; surveillance study; therapy development

DESCRIPTION (provided by applicant): Stroke is the leading cause of adult disability in the US and a leading cause of death. Mexican Americans (MA), the largest subgroup of Hispanic Americans, have a substantially higher stroke risk than European Americans, especially at younger ages where the risk is more than double. Given the greater risk and earlier onset, the impact of stroke is disproportionately experienced by MAs. Reasons for increased stroke risk in MAs are poorly understood. More than half of ischemic stroke patients have sleep apnea, a very common and important risk factor for stroke and potentially a risk factor for poor stroke outcome. No published studies have established the prevalence of sleep apnea in MAs to discern sleep apnea's contribution to excess stroke burden in this population. Small studies conducted in academic medical centers have suggested that stroke patients with sleep apnea have particularly poor stroke outcomes, but population-based studies in diverse populations are lacking. The current application seeks to investigate health disparities related to sleep apnea in stroke patients in order to understand the marked ethnic differences in stroke. This research will inform the development of interventions to prevent or treat sleep apnea in MAs, which will reduce the ethnic stroke disparity. The parent study for this project, the Brain Attack Surveillance in Corpus Christi (BASIC) project, is an ongoing population-based stroke surveillance study that identifies stroke cases in Nueces County, Texas. This study has made many important discoveries about stroke in Hispanics. BASIC will continue to identify all strokes in Nueces County until mid year 3 of the current application and will provide detailed 90-day stroke outcome data until mid year 2. The current application will extend BASIC data collection through year 5 month 3 and will add: (1) sleep apnea screening in the acute stroke period that differentiates obstructive from central events, (2) sleep apnea screening for intracerebral hemorrhage cases, (3) access to care measures for sleep apnea, and (4) genetic admixture analysis to investigate how genetics may relate to ethnic disparities in sleep apnea. The application seeks, in a cost-containing fashion, to understand and remedy the influence of a very frequent risk factor, sleep apnea, on a common, devastating disease, stroke, in the largest and fastest growing US minority population.

描述（由申请人提供）：中风是美国成人残疾的主要原因，也是死亡的主要原因。墨西哥裔美国人（MA）是西班牙裔美国人最大的亚组，中风风险要比欧洲人高得多，尤其是在风险大于两倍以上的年轻人中。考虑到更大的风险和更早的发作，MAS的中风的影响不成比例。 MAS中风风险增加的原因知之甚少。超过一半的缺血性中风患者患有睡眠呼吸暂停，这是中风的非常常见且重要的危险因素，可能是中风不良结果的危险因素。没有发表的研究确定MAS中睡眠呼吸暂停的率，以辨别睡眠呼吸暂停对这一人群中风负担过多的贡献。在学术医学中心进行的小型研究表明，中风呼吸暂停患者的中风结果较差，但缺乏基于人群的研究。当前的申请旨在调查中风患者与睡眠呼吸暂停有关的健康差异，以了解中风的明显种族差异。这项研究将为您预防或治疗MAS中睡眠呼吸暂停的干预措施的发展提供信息，这将减少族裔中风差异。该项目的家长研究是Corpus Christi（基本）项目的脑攻击监视，是一项持续的基于人群的中风监视研究，该研究确定了德克萨斯州Nueces县的中风病例。这项研究对西班牙裔中的中风有了许多重要的发现。 BASIC will continue to identify all strokes in Nueces County until mid year 3 of the current application and will provide detailed 90-day stroke outcome data until mid year 2. The current application will extend BASIC data collection through year 5 month 3 and will add: (1) sleep apnea screening in the acute stroke period that differentiates obstructive from central events, (2) sleep apnea screening for intracerebral hemorrhage cases, (3) access to care measures for sleep呼吸暂停和（4）遗传混合分析，以研究遗传学与睡眠呼吸暂停中种族差异的关系。该应用程序以一种具有成本的方式寻求理解和纠正非常频繁的风险因素，睡眠呼吸暂停对常见，毁灭性疾病，中风的影响，在美国增长最大，增长最快的美国少数民族中。