Pathways to Alcohol Use Disorders in ALSPAC: A Genetic-Developmental Study

ASPAC 中酒精使用障碍的途径：一项遗传发育研究

• 批准号: 8716609
• 负责人: DANIELLE M DICK
• 金额: $ 48.74万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-10 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8716609
• 关键词: Adolescence; Adolescent; Age; Alcohol abuse; Alcohol consumption; Alcohol or Other Drugs use; Alcohols; Area; Biological; Child; Childhood; Communities; Complex; DNA; Data; Development; Developmental Process; Dimensions; England; Enrollment; Environment; Environmental Risk Factor; Etiology; Evaluation; Funding; Gender Role; Gene Targeting; Genes; Genetic; Genetic Risk; Goals; Grant; Health; Individual; Internet; Lead; Longitudinal Studies; Mediating; Modeling; Molecular Genetics; Mothers; Outcome; Parents; Pathway interactions; Pattern; Phase; Phenotype; Predisposition; Pregnancy; Process; Questionnaires; Research Personnel; Resources; Risk; Risk Factors; Sample Size; Sampling; Schedule; Series; Sex Characteristics; Staging; Surveys; Susceptibility Gene; Symptoms; Testing; Time; United States National Institutes of Health; Universities; Virginia; alcohol use disorder; alcohol use initiation; base; boys; cohort; cost; design; developmental genetics; deviant; drinking; early childhood; follow-up; girls; interest; parental monitoring; pregnant; prenatal; prenatal exposure; psychologic; risk variant; social; trait; underage drinking; young adult

DESCRIPTION (provided by applicant): Pathways to Alcohol Use Disorders in ALSPAC: A Genetic-Developmental Study Alcohol Use Disorders (AUDs) emerge from diverse genetic and environmental risk factors acting through a range of complex developmental pathways. Very few studies exist that have a combination of sample size, representativeness, and sufficiently frequent and detailed assessments over the requisite age range to provide a realistic opportunity to disentangle these intricate etiologic pathways. The Avon Longitudinal Study of Parents and Children (ALSPAC) is such a study. Beginning with over 13,000 pregnant mothers ascertained around Avon England, the ALSPAC project has conducted detailed follow-ups of this sample for the last 16 years. The sample is now entering the critical transitional period from adolescence to young adulthood. This application, prepared by a team of investigators from Virginia Commonwealth University and University of Bristol, has three specific aims in the ALSPAC cohort. The first aim is to add detailed assessments of alcohol use and symptoms of AUDs to questionnaires already scheduled to occur at ages 18 and 20. This will allow us to capture a key developmental phase for alcohol use and the emergence of early symptoms of AUDs. The second aim is to conduct an extensive series of analyses seeking to understand the etiologic pathways to alcohol use (AU) and alcohol use problems (AUPs). The specific goals of these analyses will be (1) to characterize patterns of AU and AUPs across adolescence; (2) to identify childhood risk factors that predict AU and AUPs in adolescence and to understand the developmental processes by which these risks unfold; (3) to study the further development of these risk factors across adolescence and their interaction with emerging AU and its consequences; (4) to test the moderating role of gender on patterns, predictors, and developmental processes related to AU and AUPs; and (5) to extend models of risk for AU and AUPs into young adulthood using the age 18 and 20 data collected under Aim 1. The analyses will examine how risk unfolds across development across three major domains: Externalizing, Internalizing, and Environment (and how these eventually relate to AU and the development of AUPs). Each of these domains is broad, and one of the goals of the project will be to parse these constructs and delineate the most relevant risk dimensions. The third aim of the project is to incorporate information about a limited set of previously validated risk genes into developmental models of risk for AU, AUPs, and AUDs developed in Aim 2. This will be accomplished using molecular genetic data available on at least 3,000 subjects from the ALSPAC cohort at no cost to NIH. These analyses will allow us to study the dynamic interplay of biological, psychological, and social processes that contribute to pathways of risk (and resiliency) for AU and AUPs. With its large sample size, representativeness, detailed and frequent phenotypic assessments and availability of genotypic data, the ALSPAC cohort provides a unique opportunity to clarify, in a developmental context, the complex web of susceptibility and protective factors for AUDs.

描述（由申请人提供）：ALSPAC中酒精使用障碍的途径：遗传发展研究酒精使用障碍（AUDS）来自各种遗传和环境风险因素，这些遗传和环境风险因素通过一系列复杂的发育途径作用。很少有研究在必要的年龄范围内具有样本量，代表性和足够频繁且详细的评估的结合，以提供逼真的机会，以消除这些复杂的病因学途径。对父母和孩子（ALSPAC）的雅芳纵向研究就是这样的研究。从超过13,000位怀孕的母亲确定了雅芳（Avon England），ALSPAC项目在过去的16年中对该样本进行了详细的随访。样本现在正在进入从青春期到成年年轻的关键过渡期。该应用程序由弗吉尼亚联邦大学和布里斯托尔大学的一个调查人员团队编写，在ALSPAC队列中具有三个特定的目标。第一个目的是在已经计划在18岁和20岁时发生的调查表中添加对酒精使用和AUDS症状的详细评估。这将使我们能够捕获饮酒的关键发育阶段，并出现了EAD的早期症状。第二个目的是进行一系列广泛的分析，以了解饮酒（AU）和酒精使用问题（AUP）的病因学途径。这些分析的特定目标将是（1）表征整个青春期的AU和AUP的模式； （2）确定预测青春期AU和AUP的童年风险因素，并了解这些风险不断发展的发展过程； （3）研究整个青春期这些危险因素的进一步发展及其与出现的AU及其后果的相互作用； （4）测试性别对与AU和AUP有关的模式，预测因素和发展过程的调节作用； （5）使用AIM 1收集的18岁和20岁的数据将AU和AUP的风险模型扩展到年轻成年。分析将研究如何在三个主要领域的开发中进行风险发展：外部化，内部化和环境（以及这些最终与AU以及AU以及AUP的发展以及AUP的发展）。这些领域中的每个领域都广泛，该项目的目标之一是解析这些结构并描述最相关的风险维度。该项目的第三个目的是将有关有限的先前验证的风险基因集合到AIM 2中开发的AU，AUP和AUDS的发展模型中。将使用ALSPAC同学的至少3,000名受试者可用的分子遗传数据来实现这一目标。这些分析将使我们能够研究有助于AU和AUPS风险途径（以及弹性）的生物，心理和社会过程的动态相互作用。 ALSPAC队列具有较大的样本量，代表性，详细和频繁的表型评估以及基因型数据的可用性，为在发育环境中澄清了复杂的易感性和AUDS保护因素的独特机会。

项目成果

Disordered eating and self-harm as risk factors for poorer mental health during the COVID-19 pandemic: A UK-based birth cohort study.

饮食失调和自残是 COVID-19 大流行期间心理健康状况较差的危险因素：一项基于英国的出生队列研究。

• DOI: 10.1101/2021.04.30.21256377
• 发表时间: 2021
• 期刊: medRxiv : the preprint server for health sciences
• 作者: Warne,Naomi;Heron,Jon;Mars,Becky;Kwong,AlexSF;Solmi,Francesca;Pearson,Rebecca;Moran,Paul;Bould,Helen
• 通讯作者: Bould,Helen

The effect of parental drinking on alcohol use in young adults: the mediating role of parental monitoring and peer deviance.

• DOI: 10.1111/add.14280
• 发表时间: 2018-11
• 期刊: Addiction (Abingdon, England)
• 作者: Mahedy L;MacArthur GJ;Hammerton G;Edwards AC;Kendler KS;Macleod J;Hickman M;Moore SC;Heron J
• 通讯作者: Heron J

Effects of Excessive Alcohol Use on Antisocial Behavior Across Adolescence and Early Adulthood.

• DOI: 10.1016/j.jaac.2017.07.781
• 发表时间: 2017-10
• 期刊: Journal of the American Academy of Child and Adolescent Psychiatry
• 影响因子: 13.3
• 作者: Hammerton G;Mahedy L;Murray J;Maughan B;Edwards AC;Kendler KS;Hickman M;Heron J
• 通讯作者: Heron J

Moderate alcohol drinking in pregnancy increases risk for children's persistent conduct problems: causal effects in a Mendelian randomisation study.

怀孕期间适量饮酒会增加儿童持续行为问题的风险：孟德尔随机研究中的因果效应。

• DOI: 10.1111/jcpp.12486
• 发表时间: 2016-05
• 期刊: Journal of child psychology and psychiatry, and allied disciplines
• 作者: Murray J;Burgess S;Zuccolo L;Hickman M;Gray R;Lewis SJ
• 通讯作者: Lewis SJ

Drinking to Cope: a Latent Class Analysis of Coping Motives for Alcohol Use in a Large Cohort of Adolescents.

饮酒应对：一大群青少年饮酒应对动机的潜在类别分析。

• DOI: 10.1007/s11121-016-0652-5
• 发表时间: 2016
• 期刊: Prevention science : the official journal of the Society for Prevention Research
• 作者: Stapinski,LexineA;Edwards,AlexisC;Hickman,Matthew;Araya,Ricardo;Teesson,Maree;Newton,NicolaC;Kendler,KennethS;Heron,Jon
• 通讯作者: Heron,Jon