Training in Advanced Heart Disease Research

高级心脏病研究培训

• 批准号: 8703767
• 负责人: Joshua I Goldhaber
• 金额: $ 40.43万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8703767
• 关键词: Heart Diseases; Research; Training

DESCRIPTION (provided by applicant): The Cedars-Sinai Heart Institute (CSHI) is applying for a new Institutional Training Grant for its Advanced Heart Disease Research Training Program. The objective of the proposed Training Program is to provide outstanding team-mentored training in basic biomedical and translational research to six postdoctoral fellows (3 per year x 2 years) in order to provide them with the necessary skills to develop independent and productive academic careers in cardiovascular science. We seek to ensure that all of our trainees, be they PhDs, MDs or MD/PhDs, develop an in-depth knowledge of the basic science underpinning clinically relevant problems in cardiovascular medicine, as well as a comprehensive understanding of rigorous study design, appropriate methodology and expert technical execution of basic and clinical studies. This not only provides clinical investigators wih the skills they need to properly test hypotheses generated at the basic science level, but also informs basic scientists about the clinical aspects of disease in order to stimulate clinically relevant state-of- the-art investigations in the laboratory. Areas of research focus at the CSHI include Cardiac Biology, Arrhythmias, Vascular Biology and Atherosclerosis, Regenerative Medicine, Transplant Immunology, Cardiovascular Imaging, Women's Health, and Genetics. The Training Program takes advantage of the unique strengths of Cedars-Sinai Medical Center (CSMC), the largest private teaching hospital west of the Mississippi, which has a longstanding commitment to translational research and to serving the local community. The CSHI was established at CSMC in 2007 and has grown rapidly. It is now houses the largest adult heart transplant program in the world, performed an NIH-funded first-in-human trial of cardiac-derived stem cell therapy, and has attracted many NIH-funded basic and translational investigators. Some of these share joint appointments in other CSMC units, which include the Regenerative Medicine Institute, Biomedical Imaging Research Institute, Medical Genetics Institute, as well as the UCLA Department of Physiology. Trainees receive an intensive research experience in a focused area of investigation, augmented by a formal curriculum that includes both basic and clinical seminars, instruction in grant and manuscript writing, public speaking, biostatistics and ethics. Several courses are provided by the CSMC Department of Biomedical Sciences, the CSMC Clinical Scholars Program, and a multi-campus NIH CTSA-supported Center for Translational Science Institute (CTSI, includes CSMC, UCLA, Harbor-UCLA, and Charles Drew University). The CTSI provides our trainees with privileged access to project seed funds, additional courses in clinical research design, and tools for conducting the entire range of studies from bench to bedside to community. In summary, we have designed a program that provides in-depth training in critical areas of cardiovascular science within an environment that champions translational research and clinical excellence. We will actively recruit outstanding candidates with diverse and underrepresented backgrounds to fill the six positions (three the first year) in this training program.

描述（由申请人提供）：Cedars-Sinai Heart Institute（CSHI）正在为其先进的心脏病研究培训计划申请新的机构培训补助金。拟议的培训计划的目的是为六名博士后研究员（每年3年2年）提供基本生物医学和转化研究的出色培训，以便为他们提供必要的技能，以发展心血管科学领域的独立和富有成效的学术职业。我们试图确保我们的所有学员，无论是博士学位，MDS或MD/PHD，都会对基础科学的临床科学发展有深入的了解，以及对严格的研究设计，适当的方法论和基础技术执行的适当方法，以及对严格的研究设计的全面了解。这不仅为临床研究人员提供了适当测试基础科学上产生的假设所需的技能，而且还向基础科学家提供了有关疾病的临床方面的信息，以刺激实验室中的临床相关状态研究。 CSHI的研究重点包括心脏生物学，心律不齐，血管生物学和动脉粥样硬化，再生医学，移植免疫学，心血管成像，女性健康和遗传学。该培训计划利用了密西西比州以西最大的私立教学医院Cedars-Sinai Medical Center（CSMC）的独特优势，该医院长期致力于转化研究并为当地社区服务。 CSHI于2007年在CSMC建立，并已迅速发展。现在，它是世界上最大的成人心脏移植计划，对心脏衍生的干细胞疗法进行了NIH资助的首次人类试验，并吸引了许多由NIH资助的基本和转化研究者。其中一些在其他CSMC单位共享联合任命，其中包括再生医学研究所，生物医学成像研究所，医学遗传学研究所以及UCLA生理学系。受训人员在重点的调查领域获得了密集的研究经验，并由包括基础和临床研讨会，赠款和手稿写作的指导，公开演讲，生物统计学和道德的正式课程增强。 CSMC生物医学科学系，CSMC临床学者计划以及一个多校立NIH CTSA支持转化科学研究所中心（CTSI，包括CSMC，UCLA，UCLA，Harbor-UCLA和Charles Drew University）。 CTSI为我们的受训者提供了特权访问项目基金，临床研究设计的其他课程以及从长凳到床头再到社区进行全部研究的工具。总而言之，我们设计了一项计划，该计划在倡导转化研究和临床卓越的环境中提供心血管科学关键领域的深入培训。我们将积极招募具有多样化和代表性不足的背景的杰出候选人，以填补该培训计划的六个职位（第三年）。