Scaling and Sequencing Motor Output in Humans: fMRI Study
人类运动输出的缩放和排序:功能磁共振成像研究
基本信息
- 批准号:8515533
- 负责人:
- 金额:$ 31.39万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2005
- 资助国家:美国
- 起止时间:2005-08-01 至 2016-07-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAgeAlzheimer&aposs DiseaseAnteriorAntiparkinson AgentsAreaBasal GangliaBiological MarkersBradykinesiaBrainBrain DiseasesBrain imagingCell NucleusCellsCognitionCognitiveCognitive deficitsDataDevelopmentDiffusion Magnetic Resonance ImagingDiseaseDisease ProgressionDorsalFunctional Magnetic Resonance ImagingFundingGlobus PallidusGoalsGrantHumanImageKnowledgeLaboratoriesLevodopaLinkLongitudinal StudiesMeasuresMemoryMotorMotor CortexMotor outputMovementNatural HistoryNerve DegenerationOutcomeParkinson DiseasePatientsPharmaceutical PreparationsPhysiciansPositioning AttributePrefrontal CortexPreparationRehabilitation therapyResearchStagingStructureStructure of subthalamic nucleusSubstantia nigra structureSubthalamic structureSymptomsTestingThalamic structureTimeTremorUnited StatesUnited States National Institutes of Healthexecutive functionfallsfrontal lobegraspin vivo Modelinnovationmotor deficitputamensex
项目摘要
DESCRIPTION (provided by applicant): Longitudinal studies in Parkinson's disease (PD), that document how changes in structure and function of the brain relate to changes in movement and cognition, represent a critical component to developing new therapies that will slow the rate of progression of PD. Unfortunately, longitudinal studies of brain structure and function in PD are very rare. In years 7-12 of this renewal R01, our laboratory is well-positioned to conduct a longitudinal study since we have already tested 40 patients with PD and 40 age and sex-matched control subjects at baseline. Our research team has used diffusion tensor imaging (DTI) to show that the structural integrity of the dorsal substantia nigra is reduced with age, and that the ventral substantia nigra is reduced in early stage, de novo PD. Further, our laboratory has used functional magnetic resonance imaging (fMRI) to show that the functional activity of all basal ganglia nuclei are reduced in PD during specific grip force switching tasks. We have shown that the functional activity of basal ganglia nuclei relates to specific motor signs in PD, such as bradykinesia and tremor. In this renewal, we will compare our baseline DTI and fMRI data in 40 de novo patients with PD and 40 control subjects longitudinally to a 4 year time point. In year 4, patients will be tested off and on antiparkinsonian medication. We test the hypothesis that alterations in the structural integrity of the substantia nigra and anterior thalamus are linked to disease progression changes in motor signs and cognitive signs. As a consequence, disease progression changes in motor signs and cognitive signs will be related to region-specific changes in functional activity of the basal ganglia, thalamus, motor cortex, and frontal cortex in PD. Aim 1a will use DTI to examine the structural integrity of the substantia nigra in relation to motor signs of PD. Aim 1B will use fMRI during a well-defined force switching task to examine the relation between functional activity of the basal ganglia, thalamus, and motor cortex to motor signs of PD. Aim 2a will use DTI to examine the structural integrity of the thalamus in relation to cognitive signs of PD. Aim 2b will use fMRI during a cognitive-motor task to examine the functional activity of the caudate and frontal cortex in relation to cognitive signs of PD. The proposed research is both significant and innovative because it will be the first comprehensive study to use structural and functional brain imaging at 3 Tesla to focus on how subcortical and cortical brain structures change in patients with PD after 4 years.
描述(由申请人提供):帕金森病 (PD) 的纵向研究记录了大脑结构和功能的变化如何与运动和认知的变化相关,是开发减缓进展速度的新疗法的关键组成部分的PD。不幸的是,对帕金森病大脑结构和功能的纵向研究非常罕见。在 R01 更新的第 7-12 年,我们的实验室已经做好了开展纵向研究的准备,因为我们已经在基线上测试了 40 名 PD 患者和 40 名年龄和性别匹配的对照受试者。我们的研究团队使用弥散张量成像(DTI)显示,背侧黑质的结构完整性随着年龄的增长而降低,而腹侧黑质在早期即从头PD开始减少。此外,我们的实验室使用功能磁共振成像(fMRI)表明,在特定的握力切换任务中,所有基底神经节核的功能活动在PD中都会降低。我们已经证明基底神经节核的功能活动与帕金森病中的特定运动体征有关,例如运动迟缓和震颤。在本次更新中,我们将纵向比较 40 名新发 PD 患者和 40 名对照受试者的基线 DTI 和 fMRI 数据,为期 4 年时间点。第四年,患者将接受是否服用抗帕金森病药物的测试。我们检验了这样的假设:黑质和前丘脑结构完整性的改变与运动体征和认知体征的疾病进展变化有关。因此,运动体征和认知体征的疾病进展变化将与 PD 中基底神经节、丘脑、运动皮层和额叶皮层功能活动的区域特异性变化相关。目标 1a 将使用 DTI 检查与 PD 运动体征相关的黑质结构完整性。目标 1B 将在明确的力转换任务中使用功能磁共振成像来检查基底神经节、丘脑和运动皮层的功能活动与 PD 运动体征之间的关系。目标 2a 将使用 DTI 检查与 PD 认知体征相关的丘脑结构完整性。目标 2b 将在认知运动任务期间使用功能磁共振成像来检查尾状核和额叶皮质的功能活动与 PD 认知症状的关系。拟议的研究既重要又具有创新性,因为这将是第一个使用 3 Tesla 的结构和功能脑成像来关注 PD 患者 4 年后皮质下和皮质大脑结构如何变化的综合研究。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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David E Vaillancourt其他文献
Higher Order Gauge Equivariant CNNs on Riemannian Manifolds and Applications
黎曼流形上的高阶规范等变 CNN 及其应用
- DOI:
10.48550/arxiv.2305.16657 - 发表时间:
2023-05-26 - 期刊:
- 影响因子:0
- 作者:
Gianfranco Cortes;Yue Yu;R. Chen;Melissa S. Armstrong;David E Vaillancourt;B. Vemuri - 通讯作者:
B. Vemuri
Effect of age, ethnicity, sex, cognitive status and APOE genotype on amyloid load and the threshold for amyloid positivity
年龄、种族、性别、认知状态和 APOE 基因型对淀粉样蛋白负荷和淀粉样蛋白阳性阈值的影响
- DOI:
10.1016/j.nicl.2019.101800 - 发表时间:
2019-03-27 - 期刊:
- 影响因子:0
- 作者:
R. Duara;D. Loewenstein;D. Loewenstein;Gabriel Lizárraga;Malek Adjouadi;Warren W. Barker;M. Greig‐Custo;Mónica Rosselli;A. Peñate;Yat;Yat;Raquel Behar;A. Ollarves;C. Robayo;Kevin S. Hanson;Michael Marsiske;Michael Marsiske;S. Burke;Nilufer Ertekin‐Taner;David E Vaillancourt;S. D. Santi;Todd E. Golde;S. DeKosky - 通讯作者:
S. DeKosky
Aducanumab reduces Aβ plaques in Alzheimer's disease
Aducanumab 减少阿尔茨海默病中的 Aβ 斑块
- DOI:
10.1002/mds.26833 - 发表时间:
2016-11-01 - 期刊:
- 影响因子:8.6
- 作者:
David E Vaillancourt - 通讯作者:
David E Vaillancourt
Small effect size leads to reproducibility failure in resting-state fMRI studies
效应量小导致静息态 fMRI 研究再现性失败
- DOI:
10.1101/285171 - 发表时间:
2018-03-20 - 期刊:
- 影响因子:0
- 作者:
Xiaohan Jia;N. Zhao;Barek Barton;R. Burciu;N. Carrière;A. Cerasa;Boyu Chen;Jun Chen;S. Coombes;L. Defebvre;C. Delmaire;K. Dujardin;F. Esposito;Guofeng Fan;Di Nardo Federica;Yifang Feng;B. Fling;Saurabh Garg;M. Gilat;M. Gorges;S. Ho;F. Horak;Xiao Hu;Xiao;Biao Huang;Peiyu Huang;Zehao Jia;Christy Jones;J. Kassubek;L. Krajčovičová;Ajay S. Kurani;Jing Li;Qian Li;A. Liu;Bo Liu;Hu Liu;Weiguo Liu;Renaud Lopes;Y. Lou;Wei Luo;T. Madhyastha;Nini Mao;G. McAlonan;M. McKeown;Shirley Pang;A. Quattrone;I. Rektorová;Alessia Sarica;H. Shang;J. Shine;Priyank Shukla;T. Slavícek;Xiaoming Song;G. Tedeschi;A. Tessitore;David E Vaillancourt;Jian Wang;Jue Wang;Z. J. Wang;Lucinda Wei;Xia Wu;Xiaojun Xu;Lei Yan;J. Yang;Wanqun Yang;N. Yao;Dezhen Zhang;Jiu;Min;Yanling Zhang;Caihong Zhou;Chao;X. Zuo;M. Hallett;Tao Wu;Y. Zang - 通讯作者:
Y. Zang
Different aspects of failing to recover from proactive semantic interference predicts rate of progression from amnestic mild cognitive impairment to dementia
未能从主动语义干扰中恢复的不同方面可预测从遗忘性轻度认知障碍到痴呆的进展率
- DOI:
10.3389/fnagi.2024.1336008 - 发表时间:
2024-01-31 - 期刊:
- 影响因子:4.8
- 作者:
R. C. Curiel Cid;E. Crocco;R. Duara;David E Vaillancourt;Breton M. Asken;Melissa J Armstrong;Malek Adjouadi;Mike Georgiou;Michael Marsiske;Wei;Mónica Rosselli;W. Barker;Alexandra Ortega;Diana Hincapie;Liz Gallardo;Feras Alkharboush;Steve DeKosky;Glenn E. Smith;D. Loewenstein - 通讯作者:
D. Loewenstein
David E Vaillancourt的其他文献
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{{ truncateString('David E Vaillancourt', 18)}}的其他基金
Automated Imaging Differentiation of Parkinsonism
帕金森病的自动成像鉴别
- 批准号:
10613607 - 财政年份:2022
- 资助金额:
$ 31.39万 - 项目类别:
1Florida Alzheimer's Disease Research Center Biomarker Core
1佛罗里达阿尔茨海默病研究中心生物标志物核心
- 批准号:
10663246 - 财政年份:2020
- 资助金额:
$ 31.39万 - 项目类别:
1Florida Alzheimer's Disease Research Center Biomarker Core
1佛罗里达阿尔茨海默病研究中心生物标志物核心
- 批准号:
10413196 - 财政年份:2020
- 资助金额:
$ 31.39万 - 项目类别:
1Florida Alzheimer's Disease Research Center Biomarker Core
1佛罗里达阿尔茨海默病研究中心生物标志物核心
- 批准号:
9921607 - 财政年份:2020
- 资助金额:
$ 31.39万 - 项目类别:
1Florida Alzheimer's Disease Research Center Biomarker Core
1佛罗里达阿尔茨海默病研究中心生物标志物核心
- 批准号:
10190777 - 财政年份:2020
- 资助金额:
$ 31.39万 - 项目类别:
Non-invasive Markers of Neurodegeneration in Movement Disorders
运动障碍神经退行性变的非侵入性标志物
- 批准号:
8875784 - 财政年份:2012
- 资助金额:
$ 31.39万 - 项目类别:
Non-invasive Markers of Neurodegeneration in Movement Disorders
运动障碍神经退行性变的非侵入性标志物
- 批准号:
9068252 - 财政年份:2012
- 资助金额:
$ 31.39万 - 项目类别:
Non-invasive Markers of Neurodegeneration in Movement Disorders
运动障碍神经退行性变的非侵入性标志物
- 批准号:
8661314 - 财政年份:2012
- 资助金额:
$ 31.39万 - 项目类别:
Non-invasive Markers of Neurodegeneration in Movement Disorders
运动障碍神经退行性变的非侵入性标志物
- 批准号:
8366809 - 财政年份:2012
- 资助金额:
$ 31.39万 - 项目类别:
Non-invasive Markers of Neurodegeneration in Movement Disorders
运动障碍神经退行性变的非侵入性标志物
- 批准号:
8643868 - 财政年份:2012
- 资助金额:
$ 31.39万 - 项目类别:
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