Molecular Genetic Analysis Core

分子遗传分析核心

基本信息

批准号：
8519056
负责人：
DAVID A. NORRIS
金额：
$ 14.72万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至 2014-08-19
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8519056
关键词：
Biological Core Facility DNA Markers DNA Sequence DNA Sequence Analysis Development Equipment Funding Gene Expression Genes Genetic Genetic Markers Genetic Transcription Genotype Human Human Resources Individual Investigation Laboratory Research Maps Modeling Molecular Analysis Molecular Genetics Mus Patients Price Research Research Infrastructure Research Personnel Resources Sampling Services Single Nucleotide Polymorphism Skin Technology Training cost design discount genetic analysis genetic technology genome-wide high standard member skin disorder tool

Biological Core Facility DNA Markers DNA Sequence DNA Sequence Analysis Development Equipment Funding Gene Expression Genes Genetic Genetic Markers Genetic Transcription Genotype Human Human Resources Individual Investigation Laboratory Research Maps Modeling Molecular Analysis Molecular Genetics Mus Patients Price Research Research Infrastructure Research Personnel Resources Sampling Services Single Nucleotide Polymorphism Skin Technology Training cost design discount genetic analysis genetic technology genome-wide high standard member skin disorder tool

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项目摘要

A fundamental need of investigators studying skin disease is to carry out a number of different molecular genetic technologies, including the ability to map, identify, and characterize genes involve in skin differentiation, skin development, skin damage, and skin disease. These analyses require access to specialized high-cost equipment and highly trained personnel with specialized expertise, beyond what is typically available in most individual research laboratories. The objective of the UCD-SDRC Molecular Genetic Analysis Core is to provide investigators with the necessary tools and expertise for both large-scale and smaller-scale, user-defined genotyping of polymorphic genetic markers, large-scale and small-scale DNA sequencing, and for genomewide, multi-gene, and single-gene RNA expression analyses. Each of these technologies requires high-cost items of equipment and expertise, and the UCD-SDRC Molecular Genetic Analysis Core will coordinate access among several existing oncampus core facilities that own and operate the equipment necessary for all of these technologies, to provide these services to UCD-SDCR members at discount pricing compared to either the unsubsidized cost of these services from these core labs or the cost of these services from commercial entities. In addition, the UCD-SDRC Molecular Genetic Analysis Core will provide expertise to investigators in design of genetic studies, so as to optimize use of valuable patient samples and resources to allow investigators to answer important research questions in skin disease.

研究皮肤病的研究人员的基本需求是进行许多不同的分子遗传技术，包括映射，识别和表征基因的能力，涉及皮肤，皮肤发育，皮肤损伤和皮肤病。这些分析需要访问专业的高成本设备以及训练有素的专业知识的受过专业知识的人员，超出了大多数个人的通常研究实验室。 UCD-SDRC分子遗传分析核心的目的是提供研究者具有必要的工具和专业知识，用于大规模和较小规模的，用户定义的基因分型多态性遗传标记，大规模和小规模的DNA测序，以及用于全基因组，多基因和单基因RNA表达分析。这些技术中的每一个都需要高成本的设备和专业知识和UCD-SDRC分子遗传分析核心将协调几种现有的Oncampus的访问拥有并操作所有这些技术所需设备的核心设施，以提供这些服务以折扣价向UCD-SDCR成员提供这些核心实验室的服务或商业实体的这些服务成本。另外，UCD-SDRC 分子遗传分析核心将为研究人员提供遗传研究设计的专业知识，以便优化使用有价值的患者样品和资源的使用，以允许研究人员回答重要的研究皮肤病的问题。