BIOINFORMATICS CORE

生物信息学核心

• 批准号: 8449611
• 负责人: Li Jia
• 金额: $ 4.67万
• 依托单位: WICHITA STATE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8449611
• 关键词: Administrator; Aging; Amino Acid Sequence; Budgets; Cities; Computer Security; Core Facility; Critiques; Data; Databases; Dependence; Deposition; Development; Elements; Funding; Glycopeptides; Goals; Hour; Information Services; Institution; Internet; Ions; Kansas; Laboratories; Linux; Maintenance; Mass Spectrum Analysis; Medical center; Monitor; Nebraska; Online Systems; Participant; Peptide Sequence Determination; Peptides; Preparation; Principal Investigator; Protein Chemistry; Regrets; Research; Research Personnel; System; Technology; Universities; Wichita; Work; cost; data management; data sharing; design; graduate student; instrument; pituitary gonadal axis; platform-independent; programs; relational database; response; web based interface; web interface; web site

The goal is to develop a web-based data management system to facilitate the aging pituitary-gonadal axis research to be undertaken by three laboratories at three institutions in Kansas and Nebraska: Dr. George Bousfield's laboratory at WSU, Dr. T. Rajendra Kumar's laboratory at KUMC-Kansas City, and Dr. John Davis1 laboratory at the Nebraska Medical Center, Omaha, Nebraska. The proposed system will consist of two major components: one is a MySQL database, the other is a web interface for the database. Thus, the following two specific aims are focusing on the development of these two components respectively. 1. Design and implement a MySQL relational database to enable data sharing among laboratories. Using a database to support efficient data sharing among physically disparate laboratories is a critical element of this project. For instance, the dependence of glycopeptide ion identification in Project 2 will rely, in part, on the identification of the peptide moieties by protein sequencing which will be undertaken by Core B, the Protein Chemistry Core. In addition it will be necessary to transmit large amounts of mass spectrometry data from Project 2 to the laboratory that generates glycopeptide preparations in Project 1. The proposed database will facilitate data sharing by regular deposition of data produced by all participants in the project. 2. Design a web-based interface to enable users to access the database over the internet. The web-based interface will be implemented using the ASP.NET and powered by the Internet Information Services (IIS) web server. As the interface will be designed to be platform independent, data obtained from all instruments employed in this researchcan be deposited into the database and accessed by all the participating labs.

目的是开发基于网络的数据管理系统，以促进垂体老化 堪萨斯州和内布拉斯加州的三个机构的三个实验室将进行轴心研究：博士 WSU的乔治·布斯菲尔德（George Bousfield）的实验室，堪萨斯城（Kumc-Kansas City）的T. Rajendra Kumar博士和博士 内布拉斯加州奥马哈内布拉斯加州医疗中心的John Davis1实验室。提出的系统将组成 在两个主要组件中：一个是MySQL数据库，另一个是数据库的Web界面。因此， 以下两个具体目标分别集中在这两个组件的发展上。 1。设计和实施MySQL关系数据库，以在实验室之间启用数据共享。 使用数据库支持物理上不同实验室之间的有效数据共享是关键的 这个项目的要素。例如，项目2中糖肽离子识别的依赖性将依赖于 部分，关于通过蛋白质测序鉴定肽部分的部分，该蛋白质将由核心B进行 蛋白质化学核心。另外，有必要传输大量质谱法 从项目2到实验室的数据，该实验室在项目1中生成糖肽制剂。 数据库将通过定期沉积项目中所有参与者产生的数据来促进数据共享。 2。设计基于Web的接口，以使用户能够通过Internet访问数据库。 基于Web的界面将使用ASP.NET实现并由Internet供电 信息服务（IIS）Web服务器。由于界面将被设计为独立的平台，因此数据 从本研究中使用的所有工具中获得的 所有参与实验室。