Preventing asthma exacerbations by reducing viral respiratory infections

通过减少病毒性呼吸道感染来预防哮喘恶化

• 批准号: 8394355
• 负责人: Brenton Scott
• 金额: $ 30.13万
• 依托单位: PULMOTECT, INC
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8394355
• 关键词: Address; Aerosols; Affect; Allergic; Animal Model; Asthma; Attenuated; Biological Markers; Breathing; Cancer Patient; Cavia; Cessation of life; Clinic; Communicable Diseases; Consultations; Data; Data Set; Defense Mechanisms; Developed Countries; Development; Environment; Extrinsic asthma; Health Expenditures; Immune system; Immunity; Immunocompromised Host; In Vitro; Lead; Ligands; Lower Respiratory Tract Infection; Lower respiratory tract structure; Lung; Lung diseases; Marketing; Measurable; Measures; Metaplasia; Modeling; Mucous body substance; Mus; Pharmaceutical Preparations; Phase; Phase I Clinical Trials; Phenotype; Population; Process; Resistance; Respiratory Tract Infections; Respiratory distress; Risk; Safety; Schools; Sendai virus; Small Business Innovation Research Grant; Solutions; Technology; Toxic effect; Viral; Virus; Virus Diseases; Work; airway hyperresponsiveness; asthmatic patient; commercialization; design; eosinophilic inflammation; in vivo; interest; lost work time; mouse model; new technology; novel therapeutics; pathogen; phase 1 study; prevent; research study; response

DESCRIPTION (provided by applicant): Asthma is a leading cause of respiratory disease worldwide, with an estimated 300 million people affected and up to 250,000 deaths per year. Even in developed countries, asthma continues to be a burden for nearly 10% of the population with substantial time lost from work and school and considerable health care expenditures. The principal cause of asthma exacerbations is viral respiratory infections, estimated to be responsible for more than 70%. Pulmotect's Solution: Pulmotect has identified and is developing a novel technology to prevent respiratory infections. The lead drug (PUL-042) is a combination of two TLR ligands that stimulates the lung's own innate defense mechanisms to create a hostile environment for pathogens and prevent or attenuate respiratory infections. Both in vitro and in vivo experiments have been completed to validate this technology and the drug is progressing through the regulatory process for a treatment to benefit cancer patients during periods of immunocompromise. The focus of this proposal is to accomplish key milestones that will further transition this technology for commercialization for the asthma market by showing the direct benefit of PUL-042 in mouse asthma models. The project is organized into three measurable Specific Aims that include evaluating the safety and efficacy of PUL-042 in a mouse models of asthma. PUBLIC HEALTH RELEVANCE: Pulmotect, Inc is developing novel therapeutics that stimulate the innate immune system to protect against infectious diseases, even in cases of severely compromised immunity. Proof-of-concept data has shown that this technology effectively protects against a broad range of inhaled pathogens. This project will provide significant data to help transition this technology from the lab to the clinic for asthmatics. This work will leverage ongoing activities in developing the technology for cancer patients.

描述（由申请人提供）：哮喘是全球呼吸系统疾病的主要原因，估计每年有 3 亿人受到影响，死亡人数高达 25 万人。即使在发达国家，哮喘仍然是近 10% 人口的负担，导致他们失去工作和学习的大量时间以及大量的医疗保健支出。哮喘恶化的主要原因是病毒性呼吸道感染，估计占 70% 以上。 Pulmotect 的解决方案：Pulmotect 已经确定并正在开发一种预防呼吸道感染的新技术。主要药物 (PUL-042) 是两种 TLR 配体的组合，可刺激肺部自身的先天防御机制，为病原体创造一个不利的环境，并预防或减轻呼吸道感染。体外和体内实验均已完成，以验证该技术，并且该药物正在通过监管程序，以在免疫功能低下期间使癌症患者受益。该提案的重点是实现关键里程碑，通过展示 PUL-042 在小鼠哮喘模型中的直接益处，进一步将这项技术转化为哮喘市场的商业化。该项目分为三个可衡量的具体目标，其中包括评估 PUL-042 在哮喘小鼠模型中的安全性和有效性。 公共健康相关性：Pulmotect, Inc 正在开发新的疗法，即使在免疫力严重受损的情况下，也能刺激先天免疫系统以预防传染病。概念验证数据表明，该技术可以有效防止多种吸入病原体。该项目将提供重要数据，帮助将这项技术从实验室转移到哮喘患者的临床。这项工作将利用正在进行的为癌症患者开发技术的活动。