GDCN Clinical Center-Advancing Clinical Research in Primary Glomerular Diseases

GDCN临床中心-推进原发性肾小球疾病的临床研究

基本信息

批准号：
8734420
负责人：
Ronald J Falk
金额：
$ 83.36万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-16 至 2018-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8734420
关键词：
21 year old Age Alabama Biological Markers Biology Biopsy Canada Case-Control Studies Categories Child Childhood Clinical Clinical Research Clinical assessments Cohort Studies Collaborations Communities Contracts Data Databases Development Diagnosis Disease Enrollment Ensure Environment Focal Segmental Glomerulosclerosis Foundations Geography Government Grant Hospitals Immunoglobulin A Individual Industry Informed Consent Institution Intervention Studies Kidney Kidney Diseases Laboratories Life Membranous Glomerulonephritis Nephrology North Carolina Outcome Outcome Measure Parents Pathogenesis Pathologic Patients Pediatric Hospitals Population Private Practice Province Quality of Care Quality of life Quebec Recruitment Activity Registries Renal glomerular disease Research Research Project Grants Resources Sampling Secure Site Staging Standardization Therapeutic Intervention Time Translational Research Treatment Protocols United States Universities Virginia Work base child well being clinical care cohort data sharing disease diagnosis disease registry experience follow-up healthy volunteer human subject improved interest prospective public health relevance response success

21 year old Age Alabama Biological Markers Biology Biopsy Canada Case-Control Studies Categories Child Childhood Clinical Clinical Research Clinical assessments Cohort Studies Collaborations Communities Contracts Data Databases Development Diagnosis Disease Enrollment Ensure Environment Focal Segmental Glomerulosclerosis Foundations Geography Government Grant Hospitals Immunoglobulin A Individual Industry Informed Consent Institution Intervention Studies Kidney Kidney Diseases Laboratories Life Membranous Glomerulonephritis Nephrology North Carolina Outcome Outcome Measure Parents Pathogenesis Pathologic Patients Pediatric Hospitals Population Private Practice Province Quality of Care Quality of life Quebec Recruitment Activity Registries Renal glomerular disease Research Research Project Grants Resources Sampling Secure Site Staging Standardization Therapeutic Intervention Time Translational Research Treatment Protocols United States Universities Virginia Work base child well being clinical care cohort data sharing disease diagnosis disease registry experience follow-up healthy volunteer human subject improved interest prospective public health relevance response success

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项目摘要

DESCRIPTION (provided by applicant): For three decades we have been recruiting and retaining patients with glomerular diseases into inception cohorts in which patients, by signing informed consent, agree to be followed from the time of their disease diagnosis until they die. These inception cohorts currently include over 3,300 patients, and almost 2,000 patients with the four diseases of interest to this consortium: minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy and IgA nephropathy. Our success at recruiting and retaining patients has relied upon our Glomerular Disease Collaborative Network (GDCN). The GDCN is a partnership between the University of North Carolina (UNC) and over 600 private practice nephrologists created for the purpose of conducting research. We now have over 28 years of experience in building inception cohorts, and making use of them in advancing research by participating in single- and multi-center translational, observational, quality-of-life and therapeutic intervention studies. We propose to participate in the this RFA "Advancing Clinical Research in Primary Glomerular Diseases" as an expanded GDCN Clinical Center based on the existing UNC GDCN in collaboration with the University of Alabama at Birmingham (UAB) and with most of the hospitals in Montreal, Canada that have formed their own glomerular disease registry. Our colleagues at Vanderbilt University and Virginia Commonwealth University will join the GDCN Clinical Center once the cohorts begin recruiting. We have included in our Center the Duke University David Murdock Registry of 9,000 healthy individuals and thus we have ready access to clinical information and banked bio samples for over 600 healthy subjects. The GDCN Clinical Center will cover much of the geography of the Southeastern portion of the United States and most institutions in Quebec province. Moreover, the institutions within the GDCN Clinical Center, which have demonstrated prowess in clinical and translational research, are proposing, and will propose, an array of translational science, observational and treatment protocols pertaining to each of the glomerular diseases of interest. The GDCN Clinical Center is more than ready to participate in the organizational and scientific collaborative efforts of this proposed multicenter consortium.

描述（由申请人提供）：三十年来，我们一直在招募并保留肾小球疾病的患者进入Inception Cohorts，其中通过签署知情同意，患者同意从疾病诊断到死亡。目前，这些成立人群包括3,300多名患者，该财团感兴趣的四种疾病患者：最小的变化疾病，局灶性节段性肾小球硬化，膜性肾病和IGA肾病。我们在招募和保留患者方面的成功取决于我们的肾小球疾病协作网络（GDCN）。 GDCN是北卡罗来纳大学（UNC）与600多名私人执业肾病学家之间的合作伙伴关系，目的是为了进行研究。现在，我们拥有超过28年的成立群体的经验，并通过参与单一和多中心的翻译，观察，生活质量来推进研究方面的经验和治疗干预研究。我们建议参与此RFA“在原发性肾小球疾病方面的临床研究”，作为基于现有的UNC GDCN扩展的GDCN临床中心，与阿拉巴马大学（UAB）以及加拿大蒙特利尔的大多数医院合作，与加拿大蒙特利尔的大多数医院形成了自己的肾小球病疾病注册。我们在范德比尔特大学和弗吉尼亚联邦大学的同事一旦同伙开始招募，将加入GDCN临床中心。我们已将9,000名健康个体的杜克大学戴维·默多克（David Murdock）注册中心包括在我们的中心中，因此我们可以访问临床信息，并为600多名健康受试者提供生物样本。 GDCN临床中心将涵盖美国东南部地区和魁北克省的大多数机构的地理。此外，GDCN临床中心内的机构在临床和转化研究中表现出了能力，并提出了与每种肾小球疾病有关的一系列转化科学，观察和治疗方案。 GDCN临床中心已经准备好参加该拟议多中心财团的组织和科学合作努力。