Immune dysfunction and pulmonary hypertension in primate model of HIV infection

HIV感染灵长类动物模型中的免疫功能障碍和肺动脉高压

• 批准号: 9404231
• 负责人: Karen A Norris
• 金额: $ 23.85万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-03 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9404231
• 关键词: Immune; dysfunction; pulmonary; hypertension; primate; Immune; dysfunction; pulmonary; hypertension; primate

 DESCRIPTION (provided by applicant): Within the context of chronic HIV infection, pulmonary arterial hypertension (PAH) is a life-threatening complication characterized by pulmonary vascular remodeling, elevated pulmonary arterial pressure and right heart failure. Lack of understanding of the pathogenesis of HIV-PAH, along with deficiencies of available animal models, greatly impede identification and testing of new therapies. In this proposal, the overall objectives will focus on 1) determination of the role of chronic immune activation and inflammation on the development of PAH in a non-human primate model of HIV-PAH and 2) the evaluation of the effectiveness of anti-retroviral therapy, conventional PAH therapy and anti-inflammatory therapy in the primate model. These studies will not only address the mechanisms associated with the development of HIV-PAH, but they will provide critical information regarding the timing and targets that may be amenable to therapies aimed at both prevention and resolution of vascular damage, hemodynamic alterations and right heart dysfunction.

 描述（由应用提供）：在慢性艾滋病毒感染的背景下，肺动脉高压（PAH）是一种威胁生命的并发症，其特征是肺血管重塑，肺动脉升高和右心衰竭。缺乏对HIV-PAH发病机理的了解，以及可用动物模型的缺乏，对新疗法的识别和测试很大。在这项提案中，总体目标将重点放在1）确定慢性免疫激活和感染对PAH在非人类HIV-PAH的私人模型中的作用，以及2）评估抗网状病毒疗法的有效性，常规PAH治疗，常规模型中的抗炎性治疗。这些研究不仅将解决与HIV-PAH发展相关的机制，而且还将提供有关疗法可能适合的时间和靶标的关键信息。旨在预防和解决血管损伤，血液动力学改变和右心功能障碍。