Transrectal Imaging of Prostate Cancer Using a Globally Convergent Method

使用全局收敛方法进行前列腺癌经直肠成像

基本信息

批准号：
8257562
负责人：
HANLI LIU
金额：
$ 30.45万
依托单位：
UNIVERSITY OF TEXAS ARLINGTON
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-07-01 至 2015-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8257562
关键词：
Age Algorithms Area Benign Prostatic Hypertrophy Biological Biological Neural Networks Biopsy Blood Vessels Brain Breast Calibration Cancer Detection Cancer Etiology Cancerous Cessation of life Characteristics Clinic Clinical Computational algorithm Computer Simulation Computer software Contrast Media Data Data Set Detection Development Diagnosis Diagnostic Diagnostic Imaging Diffusion Digital Rectal Examination Early Diagnosis Economics Enzymes Evaluation Excision Exhibits Experimental Designs Face Feasibility Studies Fingers Foundations Future Generations Goals Gray unit of radiation dose Hemoglobin Histology Human Human Characteristics Image Image Analysis Imaging Device Imaging Techniques Individual Intervention Knowledge Lead Light Magnetic Resonance Imaging Malignant Neoplasms Malignant neoplasm of prostate Maps Mathematics Measurement Measures Medical Imaging Metabolic Methods Modality Modeling Modification Needle biopsy procedure Operative Surgical Procedures Optical Methods Optical Tomography Optics Organ Oxygen Patients Physiological Population Printing Process Property Prostate Prostate specific antigen measurement Prostate-Specific Antigen Prostatectomy Prostatic Neoplasms Reporting Research Resolution Risk Scheme Screening for Prostate Cancer Screening procedure Second Primary Cancers Seminal Sensitivity and Specificity Serum Serum Markers Shapes Shock Signal Transduction Solutions System Technology Testing Time Tissues Ultrasonography United States Urine Variant Water Work absorption abstracting base cancer diagnosis clinical practice cost cost effective density design effective therapy image reconstruction imaging modality improved in vivo innovation light scattering male malignant breast neoplasm man men minimally invasive novel optical imaging outcome forecast receptor reconstruction research and development technology development tissue phantom tool two-dimensional

项目摘要

Transrectal Imaging of Prostate Cancer Using a Globally Convergent Method Abstract While many technologies for medical imaging are advanced, no simple and accurate imaging tool exists to guide early detection, tissue biopsy and optimal treatment for prostate cancer. More research and technology development are needed to explore reliable and quantitative imaging means for improved prostate cancer screening, diagnosis and prognosis. The overall hypothesis for this R01 proposal is that a novel Globally Convergent Method in combination with a transrectal, multi-channel optical imaging system can be developed and used in vivo for transrectal detection and diagnosis of prostate cancer in human. The Specific Aims are: Aim 1: develop and validate a globally convergent method (GCM) to obtain 2-dimentional (2- D) reconstructed images of optical parameters (both absorption and scattering parameters) that are characteristic of human prostate cancer. Aim 2: design, implement, and validate a transrectal, multi-channel optical imaging system that can be used to measure optical signals from human prostate glands for non-invasive or minimally invasive prostate cancer diagnosis or/and screen. Aim 3(a): experimentally validate the developed 2-D GCM using human prostate-like tissue phantoms so that appropriate refinement, modification, or calibration can be explored to improve both theoretical accuracy and experimental designs. Aim 3(b): perform optical imaging measurements on ex vivo human prostate glands, which are removed from patients during prostatectomy, and compare with histology results to validate the newly developed 2-D GCM. Aim 3(c): validate the 2-D GCM and transrectal imaging system by performing in vivo human prostate measurements during prostatectomy. The optical measurements will be carried out transrectally in the beginning of the surgery before the prostate is removed and then taken again on the same ex vivo prostate gland. Comparison between the in vivo and ex vivo results will be made and utilized for improvement of the 2-D GCM and transrectal imaging system. This proposed project is a feasibility study. We wish to show that the GCM is a direct and fast imaging reconstruction algorithm with proven mathematical foundation, leading to an economic and practical NIR imager for prostate cancer detection. Also, by combining the optical tomographic imaging technique with the novel design of transrectal optical probes, the research team has a unique opportunity to obtain optical and physiological signatures of prostate cancer in human, which will enable proper planning of a future trial with a statistically significant number of subjects. The long-term goal is to utilize optically derived signatures as finger-prints of prostate cancer to diagnose the cancer in the future.

使用全局收敛方法进行前列腺癌经直肠成像抽象的虽然医学成像的许多技术都很先进，但没有简单而准确的成像现有工具可指导前列腺癌的早期检测、组织活检和最佳治疗。需要更多的研究和技术开发来探索可靠和定量的成像手段可改善前列腺癌筛查、诊断和预后。该 R01 提案的总体假设是一种新颖的全局收敛方法与经直肠、多通道光学成像系统相结合，可以开发和用于体内经直肠检测和诊断人类前列腺癌。这具体目标是：目标 1：开发并验证全局收敛方法 (GCM)，以获得二维 (2- D) 光学参数（吸收和散射参数）的重建图像是人类前列腺癌的特征。目标 2：设计、实现和验证经直肠多通道光学成像系统可用于非侵入性或非侵入性地测量来自人类前列腺的光信号微创前列腺癌诊断或/和筛查。目标 3(a)：使用人类前列腺样组织对开发的 2-D GCM 进行实验验证模型，以便可以探索适当的细化、修改或校准来改进理论准确性和实验设计。目标 3(b)：对离体人类前列腺进行光学成像测量，这些测量是在前列腺切除术期间从患者体内取出，并与组织学结果进行比较以验证新开发的二维 GCM。目标 3(c)：通过进行体内人体实验来验证 2-D GCM 和经直肠成像系统前列腺切除术期间的前列腺测量。将进行光学测量在手术开始时经直肠切除前列腺，然后取出再次在同一个离体前列腺上。体内和离体结果的比较将用于改进二维 GCM 和经直肠成像系统。该拟议项目是一项可行性研究。我们希望表明 GCM 是一种直接且快速的方法具有经过验证的数学基础的成像重建算法，可实现经济的以及用于前列腺癌检测的实用近红外成像仪。此外，通过结合光学断层成像技术与经直肠光学探头的新颖设计，研究团队有独特的机会获得前列腺癌的光学和生理特征在人类中，这将有助于正确规划具有统计显着性数字的未来试验的科目。长期目标是利用光学签名作为指纹前列腺癌以诊断未来的癌症。