Neuroinflammation in Diseases of the Central Nervous System

中枢神经系统疾病中的神经炎症

基本信息

批准号：
8837340
负责人：
DAVID L. WOODLAND
金额：
$ 0.5万
依托单位：
KEYSTONE SYMPOSIA
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-30 至 2015-09-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8837340
关键词：
Address Affect Alzheimer&apos s Disease Animal Model Area Astrocytes Basic Science Benchmarking Biological Markers Biology Blood - brain barrier anatomy Brain CSPG4 gene Cells Central Nervous System Diseases Collaborations Communities Cytokine Receptors Development Discipline Disease Educational workshop Elements Encephalitis Epidemiology Funding Genetic Homeostasis Host Defense Immunologist Immunology Inflammation Inflammatory Injury Knowledge Learning Mediating Methodology Methods Microglia Multiple Sclerosis National Institute of Neurological Disorders and Stroke Nerve Degeneration Neuraxis Neurodegenerative Disorders Neuroglia Neurologist Neurons Neurosciences Neurosciences Research New Mexico Oligodendroglia Outcome Paraneoplastic Syndromes Patients Reaction Receptor Signaling Research Research Personnel Role Scientist Signal Pathway Signal Transduction Specific qualifier value Stem cells Students Therapeutic Toll-like receptors Training Work base clinical phenotype clinical practice cytokine forging meetings microbial neoplastic nerve stem cell nervous system disorder neuroimmunology neuroinflammation novel therapeutics pathogen posters public health relevance receptor response symposium tissue repair

项目摘要

DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Neuroinflammation in Diseases of the Central Nervous System, organized by Richard M. Ransohoff, Christopher K. Glass and V. Hugh Perry. The meeting will be held in Taos, New Mexico from January 25-30, 2015. Neuroinflammation, the response of the central nervous system (CNS) to disturbed homeostasis, typifies all neurological diseases, including primary- inflammatory, developmental, traumatic, ischemic, neoplastic and neurodegenerative. Disease-associated neuroinflammatory responses aren't evolutionarily selected to minimize or repair tissue injury, and may be helpful, harmful or neutral. This Keystone Symposia meeting will: (i) address the developmental roles of neuroinflammatory cells including microglia and blood-brain barrier (BBB) neurovascular elements; (ii) clarify how neuroinflammatory reactions mediate host defense against neuroinvasive microbial pathogens, and also how the response to systemic inflammation affects the neuroinflammatory elements; (iii) specify critically- important neuroinflammatory cells (microglia; astrocytes; NG2+ glia; BBB), receptors (toll-like receptors; inflammasomes; cytokine receptors), signaling pathways and effector mechanisms; and (iv) identify the most salient targets of neuroinflammation (neurons; neural progenitor and stem cells; oligodendroglia) and mechanisms of injury. NINDS is most appropriate to support the meeting because the focus is on diseases of the CNS, i.e. Alzheimer's disease, ALS, encephalitis, paraneoplastic syndromes and Multiple Sclerosis, and because the basic science topics of microglial and astrocyte biology, blood-brain barrier and neuroinflammatory mechanisms, constitute a major focus of NINDS-funded research.

描述（由适用提供）：请求支持由Richard M. Ransohoff，Christopher K. Glass和V. Hugh Perry组织的中枢神经系统疾病中的Keystone研讨会会议。会议将于2015年1月25日至30日在新墨西哥州陶斯举行。神经炎症，中枢神经系统（CNS）对干扰稳态的反应，典型的所有神经系统疾病，包括原发性炎症性，发育性，发育性，创伤性，创伤性，缺血性，缺血性，肿瘤性和神经脱发。与疾病相关的神经炎症反应并未进化选择以最大程度地减少或修复组织损伤，并且可能是有益的，有害或中性的。这次Keystone研讨会会议将：（i）解决包括小胶质细胞和血脑屏障（BBB）神经血管元素在内的神经炎性细胞的发育作用；（ii）阐明神经炎症反应如何介导对神经侵袭性微生物病原体的宿主防御，以及对全身炎症的反应如何影响神经炎症元素；（iii）指定至关重要的神经炎性细胞（小胶质细胞；星形胶质细胞； NG2+ Glia； BBB），受体（Toll样受体；炎症；细胞因子受体），信号通路和效应器机制；（iv）确定神经炎症（神经元；神经元祖细胞和干细胞；少突齿）和损伤机制的最显着靶标。 Ninds最适合支持会议，因为重点是中枢神经系统的疾病，即阿尔茨海默氏病，ALS，ALS，脑炎，副塑性综合征和多发性硬化症，以及由于小胶质细胞和星形胶质细胞和星形生物学，血液 - 脑障碍和神经素的基础科学主题，研究的研究。