Chlorine Dioxide Gas Generators for Equipment and Room Sterilization

用于设备和房间消毒的二氧化氯气体发生器

• 批准号: 8712960
• 负责人: Jennifer M Criley
• 金额: $ 16.37万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8712960
• 关键词: Accounting; Address; American; Anesthesia procedures; Animal Housing; Animals; Antibody Formation; Area; Biomedical Research; Containment; Core Facility; Ensure; Environment; Environmental Pollution; Equipment; Expenditure; Funding; Gases; Grant; Housing; Human Resources; Illinois; Image; In Situ; Institution; Laboratory Animal Medicine; Laboratory Animals; Maintenance; Measures; Methods; Modification; Mus; Pattern; Principal Investigator; Research; Rodent; Sanitation; Services; Sterilization; Testing; Training; Transgenic Mice; Universities; Wages; animal care; animal facility; biosecurity; chlorine dioxide; college; cost; design; experience; occupational health/safety; peer; polyclonal antibody; programs; rat parvovirus; trafficking

Principal Investigator/Program Director (Last, first, middle): Criley, Jennifer, M Project Summary/Abstract The University of Illinois at Urbana-Champaign (UIUC) seeks funding to purchase two (2) portable chlorine dioxide gas generators for sterilizing specialized rodent testing equipment and laboratory animal housing rooms located across campus. The use of this sterilizing equipment to specifically eradicate Mouse and Rat Parvovirus (MPV, RPV, RMV) environmental contamination will directly impact the research of eighteen principal investigators and indirectly the entire UIUC laboratory animal care program. These eighteen principal investigators account for $19 million and $44.9 millon in total active and pending research expenditures, respectively. Currently, biomedical research expenditures for all of UIUC total $110 million (active) and $268 million (pending). There are specialized housing and testing equipment in use which makes traditional methods of sanitation of equipment not feasible. Large equipment and equipment which is mounted in rooms must be sanitized in situ which is best accomplished by sterilization with a sterilant in a true gas form - allowing for permeation of multiple components in multiple configurations. This can only be accomplished by a portable chlorine dioxide generator. Through the elimination of adventitious agents (e.g. MPV, RPV, RMV) in our rodent colonies, UIUC biomedical research will be significantly enhanced by 1) reducing research variables (i.e. introduction of pathogenic agents), 2) expanding the use of on campus, shared, core facilities and services (e.g. imaging center, anesthesia equipment, etc.), 3) facilitating the sharing of unique and valuable rodent lines with peer institutions, 4) enabling more efficient use of animal housing areas by reducing the number of rooms required to segregate "clean" and "dirty" animals and 5) allowing more efficient use of staffing and thus reducing labor costs by simplifying traffic patterns and other containment measures. The Project PI is a Diplomate of the American College of Laboratory Animal Medicine and has extensive training and experience in designing and implementing rodent biosecurity programs. Further, the PI and the other professional personnel listed on this application have veterinary, managerial, and operational oversight of the animal facilities which will be impacted by this grant. UIUC annually invests over $1,500,000 in direct support of its laboratory animal/biomedical research program. This funding targets personnel salaries, renovations/maintenance, equipment expenditures, and support of core facilities (e.g. transgenic mouse and polyclonal antibody production units). Per diem expenditures to active grants produces another $1,380,000 annually to fund our laboratory animal care and use program. The scope of this project does not have a negative impact on the environment nor does it require any renovations or modifications to the existing animal facilities. Occupational health and safety issues will be addressed to ensure safe and efficient use of the sterilizing chlorine dioxide gas generators.

首席研究员/计划主管（最后，第一，中间）：Criley，Jennifer，M 项目摘要/摘要 伊利诺伊大学Urbana-Champaign（UIUC）寻求资金购买两（2） 用于对专业啮齿动物测试设备进行消毒和 校园对面的实验室动物住房室。使用这种消毒设备 特异性根除小鼠和大鼠细小病毒（MPV，RPV，RMV）环境 污染将直接影响十八位主要研究人员的研究和间接影响 整个UIUC实验室动物护理计划。这十八位首席调查员帐户 分别有1900万美元和44.9美元的毫一积极和未决的研究支出。 目前，所有UIUC的生物医学研究支出总计1.1亿美元（Active）和268美元 百万（待处理）。 有专门的住房和测试设备正在使用，它是传统的方法 设备的卫生不可行。大型设备和设备安装在 房间必须在原位进行消毒，这是最好通过在 真正的气体形式 - 允许在多种配置中渗透多个组件。这 只能通过便携式二氧化氯生成器来完成。 通过消除我们啮齿动物殖民地中的不定代理（例如MPV，RPV，RMV）， UIUC生物医学研究将通过1）减少研究变量而显着增强（即 引入致病剂），2）扩大在校园，共享，核心设施和 服务（例如成像中心，麻醉设备等），3）促进独特的共享 以及与同伴机构的宝贵啮齿动物线，4）更有效地使用动物外壳 通过减少隔离“清洁”和“肮脏”动物所需的房间数量，5） 通过简化流量，可以更有效地使用人员配备，从而降低人工成本 模式和其他遏制措施。 PI项目是美国实验室动物医学学院的外交官 在设计和实施啮齿动物生物安全计划方面的广泛培训和经验。 此外，该应用程序上列出的PI和其他专业人员具有兽医， 管理和对动物设施的操作监督将受到这一影响 授予。 UIUC每年投资超过1,500,000美元，直接支持其实验室动物/生物医学 研究计划。这笔资金针对人事薪水，翻新/维护，设备 支出和核心设施的支持（例如转基因小鼠和多克隆抗体 生产单位）。每日债券支出每年再产生$ 1,380,000 为我们的实验室动物护理和使用计划提供资金。 该项目的范围对环境没有负面影响，也不需要 对现有动物设施的任何翻新或修改。职业健康与安全 将解决问题，以确保对二氧化氯气的安全有效使用 发电机。