The Contribution of Dentate-Neural Networks to Memory Encoding

齿状神经网络对记忆编码的贡献

• 批准号: 8396821
• 负责人: Laura Ewell
• 金额: $ 4.92万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8396821
• 关键词: Animals; Binding; Biological Neural Networks; Cells; Cues; Disease; Electrophysiology (science); Environment; Episodic memory; Event; Hilar; Hippocampus (Brain); Human; Impairment; Individual; Interneurons; Knowledge; Lead; Memory; Neurons; Pathology; Pattern; Population; Prevention; Process; Psyche structure; Role; Sensory; Short-Term Memory; Symptoms; System; Technology; Testing; Time; awake; cell type; density; dentate gyrus; experience; extracellular; in vivo; memory encoding; neuropsychiatry; research study; theories; therapeutic target; tool

DESCRIPTION (provided by applicant): Several neuropsychiatric disorders show extensive pathology in the input layer to the hippocampus, the dentate gyrus. One set of symptoms common to these diseases is impairments in memory that are consistent with proposed dentate gyrus function, such as deficits in episodic memory and working memory. Little is known, however, about the neural network mechanisms that underlie dentate gyrus memory encoding. In Aim 1 we will elucidate the dentate gyrus network mechanisms that support memory encoding by recording from dentate neuronal populations in awake behaving animals while they perform a dentate gyrus dependent working-memory task. In Aim 2 we will look at the contribution of individual classes of dentate neurons to the neural network computations essential for memory encoding, as several diseases differentially target individual classes of neurons. Completion of these aims will provide the framework to compare healthy network processes that underlie memory formation to disease processes, and may lead to therapeutic targets. PUBLIC HEALTH RELEVANCE: The observation that the human memory system is the victim to many mental diseases suggests that there may be something about how this network functions normally that makes it susceptible to a wide array of disease. This project aims to uncover the network mechanisms that underlie memory formation, in the hope that advancing the knowledge of how the network functions normally will have implications for prevention and treatment of disease.

描述（由申请人提供）：几种神经精神疾病在海马体（齿状回）的输入层显示出广泛的病理学。这些疾病常见的一组症状是与所提出的齿状回功能一致的记忆损伤，例如情景记忆和工作记忆缺陷。然而，人们对齿状回记忆编码背后的神经网络机制知之甚少。在目标 1 中，我们将阐明齿状回网络机制，该机制通过记录清醒行为动物执行齿状回依赖性工作记忆任务时的齿状神经元群来支持记忆编码。在目标 2 中，我们将研究各个类别的齿状神经元对记忆编码所必需的神经网络计算的贡献，因为几种疾病以不同的神经元类别为目标。这些目标的完成将为比较记忆形成与疾病过程的健康网络过程提供框架，并可能导致治疗目标。 公共健康相关性：人类记忆系统是许多精神疾病受害者的观察表明，该网络的正常运作方式可能存在某种因素，使其容易受到多种疾病的影响。该项目旨在揭示记忆形成背后的网络机制，希望加深对网络正常运作方式的了解，对疾病的预防和治疗产生影响。