Field Validation of New XRF Analyzers: Assessing Personal Exposure to Metals

新型 XRF 分析仪的现场验证：评估个人金属暴露情况

• 批准号: 8331371
• 负责人: Patrick J. Parsons
• 金额: $ 39.46万
• 依托单位: WADSWORTH CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-10 至 2015-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8331371
• 关键词: Affect; Analytical Chemistry; Arsenic; Award; Biological; Biological Monitoring; Blood; Cadmium; Capital; Centers for Disease Control and Prevention (U.S.); Chinese People; Collaborations; Communities; Cosmetics; Data; Databases; Development; Engineering; Environment; Environmental Epidemiology; Environmental Exposure; Environmental Health; Epidemiologic Studies; Epidemiologist; Epidemiology; Exposure to; Fluorescence; Food; Funding; Future; Gel; Goals; Gold; Health; Heart; Heavy Metals; Home environment; Home visitation; House Call; Human; Hygiene; Individual; Inorganic Chemistry; Juice; Laboratories; Lead; Life; Liquid substance; Lotion; Measurement; Measures; Mercury; Metal exposure; Metals; Methods; New York; Nuts; Occupational Epidemiology; Optics; Participant; Perfume; Population; Powder dose form; Process; Questionnaires; Reporting; Research; Roentgen Rays; Sampling; Schedule; Scientist; Site; Small Business Innovation Research Grant; Soaps; Solid; Specimen; Spices; Sterile coverings; System; Tea; Techniques; Testing; The Sun; Toothpaste; Trace Elements; Training; United States National Institutes of Health; Urine; Validation; Water; Wine; Work; Workplace; X-Ray Emission Spectrometry; base; cost; design; dietary supplements; disorder prevention; experience; exposed human population; field study; human subject; improved; instrument; instrumentation; multidisciplinary; new technology; novel; nuclear chemistry; pill; programs; prototype; response; skills; tool; toxic metal; usability; validation studies

DESCRIPTION (provided by applicant): A new Personal Exposure Analyzer (PEA) has been developed with NIH funding by X-Ray Optical Systems (XOS), East Greenbush, New York, and is based on a novel, non-destructive spectroscopic technique called energy dispersive (ED) monochromatic micro-X-ray fluorescence (M5XRF). This novel analyzer is designed to be used in the field by non-laboratory trained staff to assess human exposure to multiple metals in a variety of sample types (e.g., cosmetics, personal hygiene products) and matrices (e.g., liquid to solid) that an individual is exposed to or comes into contact with in a variety of environmental contexts (e.g., home or workplace). This includes samples of liquids we consume (water, juice, tea, wine, salad dressings, and other condiments, etc.); lotions and gels that are applied to the body (makeup, perfume, sun block, antiperspirant, shampoo, soap, toothpaste, and other personal hygiene products, etc.); as well as samples of food or ingestible material (spices, nuts, dietary supplements, pills, etc.) that can be easily crushed, powdered, or homogenized. The primary goal of this project is to validate exposure measurements obtained with this new analyzer under field conditions by deploying it in an on-going biomonitoring study of mercury exposure in subjects of ethnic Chinese background living in the Capital Region (Albany- Schenectady-Troy) of New York State, funded by a CDC award to New York State. Between 25 and 30 personal environmental samples will be collected during scheduled home visits to participants, along with biological samples (urine, blood), and analyzed for metal content (including mercury). The samples analyzed on site with the PEA will also be analyzed for metal content in a reference laboratory using "gold" standard methods of analysis. Results from the XRF (non-destructive) analyzer and the high-cost, gold standard laboratory-based methods (destructive) will be compared to the PEA results as part of the validation process. The validity, ease of use and ruggedness of the analyzer will be assessed under field conditions and the data used to assess it potential for use in other epidemiological studies. This project builds on an existing collaborative relationship between scientific and engineering staff from XOS, and environmental analytical scientists from the New York State Department of Health's Wadsworth Center. The research team also builds on a growing collaborative relationship between Wadsworth Center scientists and environmental epidemiologists working with the NYS DOH's Center for Environmental Health, in Troy New York.

描述（由申请人提供）：纽约东格林布什的 X 射线光学系统 (XOS) 在 NIH 的资助下开发了一种新型个人暴露分析仪 (PEA)，该分析仪基于一种称为“非破坏性光谱技术”的新型非破坏性光谱技术。能量色散 (ED) 单色微 X 射线荧光 (M5XRF)。这种新颖的分析仪设计供未经实验室培训的工作人员在现场使用，以评估人体对各种样品类型（例如化妆品、个人卫生产品）和基质（例如液体到固体）中多种金属的暴露情况，个人暴露于或接触各种环境环境（例如家庭或工作场所）。这包括我们消耗的液体样本（水、果汁、茶、酒、沙拉酱和其他调味品等）；用于身体的乳液和凝胶（化妆品、香水、防晒霜、止汗剂、洗发水、肥皂、牙膏和其他个人卫生用品等）；以及易于压碎、粉末或均质化的食品或可摄入材料的样品（香料、坚果、膳食补充剂、药丸等）。该项目的主要目标是通过将这种新型分析仪部署到居住在首都地区（奥尔巴尼-斯克内克塔迪-特洛伊）的华裔背景受试者的汞暴露持续生物监测研究中，验证在现场条件下使用这种新型分析仪获得的暴露测量值。纽约州，由疾病预防控制中心授予纽约州的奖项资助。在定期对参与者进行家访期间，将收集 25 至 30 个个人环境样本以及生物样本（尿液、血液），并分析金属含量（包括汞）。使用 PEA 现场分析的样品还将在参考实验室中使用“金”标准分析方法进行金属含量分析。作为验证过程的一部分，XRF（非破坏性）分析仪和高成本、金标准实验室方法（破坏性）的结果将与 PEA 结果进行比较。分析仪的有效性、易用性和耐用性将在现场条件下进行评估，并使用数据来评估其用于其他流行病学研究的潜力。该项目建立在 XOS 的科学和工程人员与纽约州卫生部沃兹沃斯中心的环境分析科学家之间现有的合作关系的基础上。该研究小组还建立在沃兹沃斯中心科学家和环境流行病学家与纽约州卫生部环境健康中心（位于纽约特洛伊）之间不断发展的合作关系的基础上。

项目成果

Characterization of Arsenic in dried baby shrimp (Acetes sp.) using synchrotron-based X-Ray Spectrometry and LC coupled to ICP-MS/MS.

使用基于同步加速器的 X 射线光谱法和 LC 与 ICP-MS/MS 联用对干幼虾 (Acetes sp.) 中的砷进行表征。

• DOI: 10.1039/c8ja00094h
• 发表时间: 2018-10-01
• 期刊: Journal of analytical atomic spectrometry
• 影响因子: 3.4
• 作者: D. Guimarães;Austin A. Roberts;Mina W. Tehrani;Rong Huang;L. Smieska;A. Woll;Shao‐Xian Lin;P. Parsons
• 通讯作者: P. Parsons

Evaluation of a New Optic-Enabled Portable XRF Instrument for Measuring Toxic Metals/Metalloids in Consumer Goods and Cultural Products.

用于测量消费品和文化产品中有毒金属/非金属的新型光学便携式 XRF 仪器的评估。

• DOI: 10.1016/j.sab.2016.03.010
• 发表时间: 2016-08-01
• 期刊: Spectrochimica acta. Part B, Atomic spectroscopy
• 作者: Guimarães D;Praamsma ML;Parsons PJ
• 通讯作者: Parsons PJ