Statistical collaboration in environmental health research

环境健康研究中的统计合作

• 批准号: 8929819
• 负责人: grace e kissling
• 金额: $ 11.45万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8929819
• 关键词: Agreement; Angioplasty; Animals; Antinuclear Antibodies; Antioxidants; Area; Arteries; Biological Assay; Biometry; Caliber; Case-Control Studies; Cell Adhesion; Cells; Collaborations; Computer Simulation; Coronary; Coronary artery; DNA Repair; Data; Data Analyses; Disease; Environmental Exposure; Environmental Health; Epidemiologic Studies; Event; Exposure to; Extramural Activities; Financial compensation; Genes; Genetic Polymorphism; Genomics; Genotype; Goals; Government Agencies; Health; Hormonal; Human; Institution; Metals; Mining; Mission; Modeling; Mutation; National Institute of Environmental Health Sciences; Occupational Asthma; Paper; Pharmaceutical Preparations; Policies; Prevalence; Probability; Publications; Research; Research Design; Research Personnel; Risk; SOD2 gene; Specimen; Stents; Superoxide Dismutase; Surveys; Testing; Thrombosis; Tubal Ligation; Universities; Urine; Uterine Fibroids; Woman; Writing; anticancer research; base; bisphenol A; cancer risk; cytokine; design; malignant breast neoplasm; prevent; reproductive; tumorigenesis; Agreement; Angioplasty; Animals; Antinuclear Antibodies; Antioxidants; Area; Arteries; Biological Assay; Biometry; Caliber; Case-Control Studies; Cell Adhesion; Cells; Collaborations; Computer Simulation; Coronary; Coronary artery; DNA Repair; Data; Data Analyses; Disease; Environmental Exposure; Environmental Health; Epidemiologic Studies; Event; Exposure to; Extramural Activities; Financial compensation; Genes; Genetic Polymorphism; Genomics; Genotype; Goals; Government Agencies; Health; Hormonal; Human; Institution; Metals; Mining; Mission; Modeling; Mutation; National Institute of Environmental Health Sciences; Occupational Asthma; Paper; Pharmaceutical Preparations; Policies; Prevalence; Probability; Publications; Research; Research Design; Research Personnel; Risk; SOD2 gene; Specimen; Stents; Superoxide Dismutase; Surveys; Testing; Thrombosis; Tubal Ligation; Universities; Urine; Uterine Fibroids; Woman; Writing; anticancer research; base; bisphenol A; cancer risk; cytokine; design; malignant breast neoplasm; prevent; reproductive; tumorigenesis

We provide biostatistics expertise for a number of NIEHS and NTP researchers, as well as researchers at universities and other government agencies who are conducting research related to the mission of the NIEHS. In these collaborations, we provide advice about study design, analyze data, interpret statistical results, and participate in writing papers for publication. Over the past year, we have been involved in the five research areas described below. As part of an NTP interagency agreement, we collaborated with researchers at NIOSH and the University of Cincinnati on a case-control study of the effects of genes and exposure to diisocyanates on the occurrence of occupational asthma. Based on our statistical analyses, we identified polymorphisms in several cytokine and antioxidant defense genes that are associated with occupational asthma. The polymorphism having the strongest association is within the superoxide dismutase (SOD2) gene. We collaborated with several NIEHS researchers who conduct research on mechanisms of DNA repair, mutation, and tumorigenesis. By testing for differences between genotype groups, calculating mutation probabilities and/or generating computer simulations of mutations, we found genes and sequences of genomic events involved in mutations and DNA repair. We collaborated with NIEHS and extramural researchers who are mining survey data to discover associations between environmental exposures and disease. In one study, we examined the association between tubal ligation and breast cancer risk and found no increased risk. In other studies, we found that coronary stents coated with a drug were more effective in preventing thrombosis than bare metal stents, and that thrombosis is more likely several years after a stent is placed in a coronary artery compared to simply expanding the diameter of the artery through angioplasty. We also contributed to a study of associations between reproductive and hormonal status and prevalence of antinuclear antibodies in U.S. women. We contributed to studies that characterized the histopathological features of uterine fibroids, the adhesion of cells that occurs in cancer, and the research-related compensation policies of U.S. research institutions. Finally, we examined the stability of bisphenol A concentrations assayed in urine specimens across a variety of experimental conditions. The results of these analyses were used to determine how specimens should be handled when this assay is used in epidemiological studies.

我们为许多NIEHS和NTP研究人员以及大学和其他正在进行与NIEHS任务有关的研究的大学的研究人员以及其他政府机构提供生物统计学专业知识。在这些合作中，我们提供有关研究设计，分析数据，解释统计结果并参与写作论文出版的建议。在过去的一年中，我们参与了下面描述的五个研究领域。 作为NTP跨部门协议的一部分，我们与NIOSH和辛辛那提大学的研究人员合作，对基因影响和暴露于双异氰酸酯对职业哮喘的影响的病例对照研究。根据我们的统计分析，我们确定了与职业哮喘相关的几种细胞因子和抗氧化防御基因中的多态性。具有最强关联的多态性在超氧化物歧化酶（SOD2）基因内。 我们与几位NIEHS研究人员合作，他们就DNA修复，突变和肿瘤发生的机制进行了研究。通过测试基因型组之间的差异，计算突变概率和/或生成突变的计算机模拟，我们发现了与突变和DNA修复有关的基因和基因组事件序列。 我们与正在挖掘调查数据的NIEHS和校外研究人员合作，以发现环境暴露与疾病之间的关联。在一项研究中，我们检查了输卵管结扎与乳腺癌风险之间的关联，发现风险没有增加。在其他研究中，我们发现涂有药物的冠状动脉支架在预防血栓形成方面比裸金属支架更有效，并且与简单地通过血管成形术扩大动脉直径相比，血栓形成更可能是在将支架放在冠状动脉中的几年。 我们还为美国妇女中抗核抗体的生殖和荷尔蒙状态和抗核抗体的患病率之间的关联做出了贡献。 我们贡献了特征在于子宫肌瘤的组织病理学特征，癌症中细胞的粘附以及美国研究机构与研究相关的补偿政策的研究。 最后，我们检查了在各种实验条件下在尿液样本中测定的双酚A浓度的稳定性。这些分析的结果用于确定在流行病学研究中使用该测定时应如何处理样品。