Perfluoroalkyl chemicals and the risk of developing clinical and subclinical CVD

全氟烷基化学品和发生临床和亚临床 CVD 的风险

• 批准号: 8365439
• 负责人: Anoop Shankar
• 金额: $ 39.41万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8365439
• 关键词: Abdomen; Acetic Acids; Acids; Address; Adult; Alcohol consumption; Alkanesulfonates; American; Ancillary Study; Animals; Ankle; Asian Americans; Atherosclerosis; Behavior; Blood; Blood Pressure; Body mass index; C-reactive protein; Calcium; Cardiovascular Diseases; Carpet; Chemical Exposure; Chemicals; Chinese People; Chronic Kidney Failure; Clinical; Cohort Studies; Control Groups; Coronary; Coronary artery; Coronary heart disease; Cross-Sectional Studies; Data; Disease; Environment; Ethnic Origin; Ethnic group; Exposure to; Filtration; Fire - disasters; Food; Funding; Future; Gender; General Population; Health; Hispanics; Household; Human; Laboratories; Left; Left Ventricular Mass; Licensing; Lipids; Literature; Longitudinal Studies; Lubricants; Measures; Medial; Microalbuminuria; National Heart, Lung, and Blood Institute; Outcome; Outcome Study; Paper; Parents; Participant; Physical Examination; Play; Polishes; Procedures; Prospective Studies; Public Health; Questionnaires; Race; Research Design; Resources; Risk; Role; Sampling; Serum; Smoking; Societies; Stroke; Sulfonamides; Surveys; Text; Textiles; Thick; United States; United States National Institutes of Health; Ventricular; Visit; Woman; cardiovascular disorder risk; cohort; cost effective; design; fasting glucose; follow-up; glomerular basement membrane; indexing; men; perfluorodecanoic acid; perfluorohexane; perfluorooctane; perfluorooctane sulfonate; population based; post gamma-globulins; prevent; prospective; racial and ethnic; racial/ethnic difference; surfactant

DESCRIPTION (provided by applicant): The overall aim of this proposal is to study the prospective association between serum levels of PFCs and the risk of developing coronary heart disease (CHD), stroke, cardiovascular disease (CVD), subclinical measures of atherosclerosis and hypertensive left ventricular changes among the participants of the of the Multi-ethnic Study of Atherosclerosis (MESA), a large, multiethnic, population-based, longitudinal cohort study with participants representing both men and women and the various racial/ethnic groups in the US, including whites, blacks, Hispanics, and Asian Americans and with up to 10 years of follow-up data. We will also evaluate gender and racial/ethnic differences in PFC exposure among Americans in this contemporary general population sample and examine if the association between PFCs and CVD vary by gender, or race/ethnicity. Ours is an ancillary study that builds upon the existing strengths and resources of the NIH-funded, parent MESA cohort study to address our multiple study aims in an efficient and cost-effective manner. In the MESA, we already have data on 1) the main study outcomes, including incident CHD, stroke, and CVD validated following standard criteria and procedures adapted from other successful studies such as the NHLBI-funded ARIC study, subclinical measures of atherosclerosis including coronary artery calcium (CAC), abdominal aortic calcium (AAC), carotid intimal-medial thickness (CIMT), low ankle-brachial index (ABI), and hypertensive left ventricular parameters including left ventricular mass, volume and mass to volume (M/V) ratio 2) detailed questionnaire, physical examination, and laboratory data on potential confounding factors such as smoking, alcohol intake, body mass index (BMI), blood pressure, fasting glucose, serum lipids, high sensitivity C-reactive protein, and several other markers. In the current study, we propose a case-cohort study nested within the MESA cohort to newly measure serum levels of perfluorooctanoic acid (PFOS), perfluorooctane sulfonate (PFOA), perfluorohexane sulfonate (PFHxS), perfluorononanoic acid (PFNA), and 7 other commonly detected PFCs, including perfluoroheptanoic acid (PFHpA), perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUnA), perfluorododecanoic acid (PFDoA), perflurooctane sulfanomide (PFOSA), 2-(N-ethyl-perflurooctane sulfonamido) acetic acid (Et-PFOSA-AcOH), and 2-(N-methyl-perflurooctane sulfonamide) acetic acid (Me- PFOSA-AcOH), in the baseline serum of all incident CHD (n=523), and stroke (n=224), cases and a race- stratified cohort random sample of n=1000 participants (35% white, 28% black, 22% Hispanic and 12% Chinese). This study design will allow us to examine the longitudinal associations between baseline serum PFC levels and multiple outcomes using the same "control" group as well as to make valid cross-sectional comparisons (e.g. serum PFC levels by race-ethnicity). Our study is significant because it addresses a critical barrier in the field: the lack of longitudinal studies examining the relationship between PFC exposure and the risk of clinical and subclinical measures of CVD. PUBLIC HEALTH RELEVANCE: Perfluroalkyl chemicals (PFC) are detectable in the blood of >98% of US adults. We will study the association between blood PFCs and cardiovascular disease. If we find an association, it indirectly suggests that reducing PFCs may have a role in preventing these diseases.

描述（由申请人提供）：本提案的总体目标是研究 PFC 血清水平与患冠心病 (CHD)、中风、心血管疾病 (CVD)、动脉粥样硬化和高血压的亚临床措施之间的前瞻性关联动脉粥样硬化多种族研究 (MESA) 参与者的左心室变化，这是一项大型、多种族、以人群为基础的纵向队列研究，参与者代表男性和女性以及不同种族的人。美国的种族/族裔群体，包括白人、黑人、西班牙裔和亚裔美国人，并有长达 10 年的跟踪数据。我们还将评估当代一般人群样本中美国人 PFC 暴露的性别和种族/民族差异，并研究 PFC 与 CVD 之间的关联是否因性别或种族/民族而异。我们的研究是一项辅助研究，它建立在 NIH 资助的母公司 MESA 队列研究的现有优势和资源的基础上，以高效且具有成本效益的方式实现我们的多个研究目标。在 MESA 中，我们已经掌握了 1) 主要研究结果的数据，包括事件 CHD、中风和 CVD，这些结果按照改编自其他成功研究（例如 NHLBI 资助的 ARIC 研究）的标准标准和程序进行了验证，动脉粥样硬化的亚临床测量（包括冠状动脉）动脉钙 (CAC)、腹主动脉钙 (AAC)、颈动脉内膜中层厚度 (CIMT)、低踝肱指数 (ABI) 和高血压左心室参数包括左心室质量、体积和质量与体积 (M/V) 比 2) 有关潜在混杂因素（如吸烟、饮酒、体重指数 (BMI)、血压、禁食）的详细调查问卷、体格检查和实验室数据葡萄糖、血脂、高敏 C 反应蛋白和其他一些标记物。在当前的研究中，我们提出了一项嵌套在 MESA 队列中的病例队列研究，以新测量全氟辛酸 (PFOS)、全氟辛烷磺酸 (PFOA)、全氟己烷磺酸 (PFHxS)、全氟壬酸 (PFNA) 和其他 7 种物质的血清水平常见检测到的 PFC，包括全氟庚酸 (PFHpA)、全氟癸酸 (PFDA)、全氟十一烷酸 (PFUnA)、全氟十二烷酸 (PFDoA)、全氟辛烷磺酰胺 (PFOSA)、2-(N-乙基全氟辛烷磺酰胺) 乙酸 (Et-PFOSA-AcOH) 和 2-(N-甲基全氟辛烷磺酰胺) 乙酸酸（Me-PFOSA-AcOH），在所有受试者的基线血清中突发冠心病 (n=523) 和中风 (n=224) 病例以及 n=1000 名参与者的种族分层队列随机样本（35% 白人、28% 黑人、22% 西班牙裔和 12% 中国人）。这项研究设计将使我们能够使用相同的“对照组”检查基线血清 PFC 水平与多种结果之间的纵向关联，并进行有效的横断面比较（例如按种族的血清 PFC 水平）。我们的研究意义重大，因为它解决了该领域的一个关键障碍：缺乏检查 PFC 暴露与 CVD 临床和亚临床测量风险之间关系的纵向研究。 公共卫生相关性：> 98% 的美国成年人的血液中可检测到全氟烷基化学物质 (PFC)。我们将研究血液 PFC 与心血管疾病之间的关联。如果我们发现两者之间存在关联，则间接表明减少 PFC 可能有助于预防这些疾病。