Morphology Core

形态核心

• 批准号: 8737940
• 负责人: DAVID K MEYERHOLZ
• 金额: $ 10.75万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8737940
• 关键词: Anatomy; Comparative Pathology; Consultations; Cost Savings; Data Quality; Economics; Electronic Mail; Equipment; Experimental Designs; Family suidae; Functional disorder; Goals; Human Resources; Image Analysis; Immunohistochemistry; Individual; Instruction; Laboratories; Medicine; Microscopic; Modeling; Morphology; Nature; Pathologist; Pathology; Phenotype; Physiology; Program Research Project Grants; Reagent; Research; Research Personnel; Resources; Services; Slide; Staining method; Stains; Suggestion; Technical Expertise; Techniques; Tissues; Veterinary Pathology; experience; follow-up; improved; indexing; programs; research study; tissue processing; web site

The goal ofthe Pathology Core is to provide professional services and expertise to all Investigators ofthe Program Project Grant. To facilitate these goals the Pathology Core will provide 1) technical assistance for labor intensive histotechnology techniques from tissue processing to specialized staining, 2) professional veterinary pathology support for gross, microscopic and anatomic phenotyping of the CF pig studies, 3) economic benefits through centralization of equipment, experienced professional staff and availability of specialized reagents, and 4) consultation and instruction in specialized morphologic techniques and image analysis. Program Investigators will have full access to the Core's expertise and resources. The Pathology Core will provide its services to Program Investigators in a timely and efficient manner for optimal assessment of tissues. The Specific Aims of the Pathology Core are: 1) Provide scientific support, expertise and technical labor for microscopic slide processing from tissues, routine to specialized application of histochemical stains, and immunohistochemistry techniques. 2) Provide expertise and resources to develop new morphologic or morphometric techniques as required to facilitate the needs of Project Investigators. 3) Provide veterinary pathology support (though boarded veterinary pathologists) for examination and interpretation of gross to microscopic tissues from the CF pig model and for consultation in experimental design. ¿ 4) Provide expertise and a uniform framework for the standardized assessment of tissues collected by Project Investigators to define a comprehensive anatomic assessment/phenotype of porcine CF models and experiments.

病理核心的目标是向计划项目赠款的所有调查人员提供专业服务和专业知识。为了促进这些目标，病理学核心将为劳动密集型组织技术技术提供从组织加工到专业染色的技术援助，2）针对CF Pig研究的总体，微观和解剖学表型的专业兽医病理学支持，3）经验的专业员工和专业的互助和4）咨询和4）咨询和4）咨询和4）。计划调查人员将完全访问核心的专业知识和资源。病理核心将及时有效地向计划调查人员提供服务，以最佳的组织评估。病理核心的具体目的是： 1）提供科学支持，专业知识和技术劳动，用于从组织，常规到组织化学污渍的专业应用以及免疫组织化学技术的微观幻灯片处理。 2）提供专业知识和资源，以根据需要开发新的形态学或形态计量学技术，以促进项目研究人员的需求。 3）提供兽医病理支持（尽管登上兽医病理学家），以检查和解释CF Pig模型和实验设计咨询的显微镜组织。 » 4）提供专业知识和统一框架，用于对项目研究人员收集的组织的标准化评估，以定义猪CF模型和实验的全面解剖评估/表型。