DATA ANALYSIS OF STILLBIRTH COLLABORATIVE RESEARCH NETWORK

死产协作研究网络的数据分析

• 批准号: 8880555
• 负责人: CORETTE PARKER
• 金额: $ 25.42万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-10 至 2015-04-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8880555
• 关键词: Accounting; Autopsy; Biological Assay; Birth; Black race; Blood typing procedure; Case-Control Studies; Collection; Contractor; DNA analysis; Data; Data Analyses; Databases; Diabetes Mellitus; Documentation; Drug Addiction; Enrollment; Ethnic Origin; Hospitalization; Interview; Life; Liquid substance; Live Birth; Maternal Age; Morbidity - disease rate; National Institute of Child Health and Human Development; Not Hispanic or Latino; Nulliparity; Obesity; Outcome; Overweight; Paper; Pathologic; Pathology; Placenta; Pregnancy; Principal Investigator; Protocols documentation; Publications; Recording of previous events; Records; Reporting; Research; Risk; Risk Factors; Sampling; Smoking; Specific qualifier value; Specimen; Time; Tissues; Vital Status; biobank; fetal; microbiome; population based; prenatal; stillbirth

The Stillbirth Collaborative Research Network (SCRN) has conducted the largest population based case-control study of stillbirth to date. 663 stillbirths and 1900 live births were enrolled at delivery. Data are available from maternal interviews, abstraction of delivery and prenatal records, collection and assay of biologic specimens, and pathologic examination of the placenta (stillbirths and live births). In addition, for each enrolled live birth, outcomes of the birth hospitalization (vital status, morbidities) have been recorded. A detailed postmortem protocol for fetal autopsy was performed for 85% of the stillbirths enrolled and data is available from detailed pathology forms. A number of biologic specimens have been collected and stored in a tissue and fluid bank for later analysis and DNA has been extracted from certain samples and stored at the NICHD biorepository. Analysis of risk factors known at the time of pregnancy confirmation showed the following were independently associated with an increased risk for stillbirth: non-Hispanic black race/ethnicity; previous stillbirth; nulliparity with and without previous losses at less than 20 weeks’ gestation; diabetes; maternal age 40 years or older; maternal AB blood type; history of drug addiction; smoking during the 3 months prior to pregnancy; obesity/overweight; not living with a partner; and plurality. However these risk factors accounted for only a small amount of the increase risk for

死产协作研究网络（SCRN）进行了最大的基于人群的病例对照研究 迄今为止。有663次死产和1900例活产。数据可从 产妇访谈，交付和产前记录的抽象，生物学收集和评估 子宫结核（死胎和活产）的标本和病理检查。另外， 每个注册的活产，出生住院的结果（生命状况，病态）已经 记录。对胎儿尸检进行了详细的验尸方案，对死产的85％进行 已注册和数据可从详细的病理表格获得。许多生物标本具有 收集并存储在组织和流体库中，以供以后分析，并提取了DNA 从某些样品中存储在NICHD生物座位上。 妊娠确认时已知的危险因素的分析表明，以下是 与死产的风险增加：非西班牙裔黑人种族/种族； 以前的死产；在不到20周的妊娠时，有和没有以前的损失的无效； 糖尿病;孕产妇40岁或以上；母亲腹部血型；吸毒历史； 在怀孕前三个月吸烟；肥胖/超重；不与伴侣一起生活；和 复数。但是，这些风险因素仅占少量的增加风险