Studies of other risk factors for radiosensitive tumors

放射敏感性肿瘤其他危险因素的研究

• 批准号: 8938280
• 负责人: Amy Berrington
• 金额: $ 44.95万
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8938280
• 关键词: Asthma; Back; Cancer Patient; Child; Childhood Leukemia; Chinese People; Chronic; Country; County; Data; Data Set; Disease; Effectiveness; Enrollment; Environmental Exposure; Epidemiologic Studies; Etiology; European; Evaluation; Family; Folic Acid; Gallbladder; Genetic; Hospitals; Incidence; Individual; Interview; Life Style; Link; Malignant Childhood Neoplasm; Malignant Neoplasms; Malignant neoplasm of brain; Malignant neoplasm of thyroid; Mission; Mothers; Neural Tube Defects; Obesity; Pilot Projects; Play; Population; Prospective Studies; Province; Publications; Publishing; Research; Risk; Risk Factors; Role; Sampling; Site; Testing; Thyroid Gland; Work; case control; cohort; community intervention; intervention program; mortality; offspring; tumor; waist circumference

Thyroid cancer incidence rates have been increasing for the last 3 decades in the US and the reasons for this are largely unknown. We have been studying potential risk factors for the disease in a pooled analysis of 5 NCI prospective studies. This pooling project provided some of the strongest evidence to date that obesity may be a risk factor for thyroid cancer and the rising obesity rates could therefore be part of the explanation for the rise in thyroid cancer incidence rates. We are now expanding this pooling project to include data from 15 European and US cohorts to examine the relationship in more detail including the risk associated with central adiposity and the relationship between obesity and rarer thyroid cancer subtypes.NCI Cohort Consortium BMI Pooling Project - We built a rich dataset of lifestyle risk factor and mortality data from 20 prospective studies and over 1.5 million people to study the relationship between BMI and all cause mortality. The results from this detailed analysis published in 2010 suggested that optimal BMI was in the range 20-25. We are currently exploring the association between waist circumference and all cause mortality, and expanding the pooling project to look at cancer incidence for rare cancers including thyroid and gallbladder. These cancers are typically difficult to study in individual cohorts because the numbers of cases is limited.Childhood Cancer In Chinese Children and Family Cohorts -We are conducting two pilot studies to test the feasibility of (1) follow and participation in interviews of a sample of 500 families from two county sites where the Community Intervention Program (CIP) was carried out in the mid-1990s and (2) identification of incident pediatric cancers arising among thoseborn during 1994-96 in hospitals serving the CIP population and ability to link these pediatric cancer patients back to the CIP population. The CIP community intervention program trial, which was carried out during 1994-96 in three large counties northeast and south of Beijing, evaluated the effectiveness of periconceptional folic acid supplements in reducing neural tube defects. There were dramaticreductions in neural tube defects among offspring of mothers who took folic acid supplements during thepericonceptional period. Publications from case-control epidemiologic studies in the past 10 years from Western countries have shown that periconceptional folic acid supplements may reduce risks of pediatric leukemia and potentially other pediatric cancers in offspring of mothers who take these supplements. Otherstudies have shown statistical associations with periconception folic acid and other serious chronic diseasesof offspring including asthma. The pilot studies will attempt to trace, enroll, and interview 500 families fromTaicang, Jiangsu Province and Laoting, Hebei Province and will seek to identify all pediatric cancers diagnosedduring 1994 to the present among children born during 1994-96 and link these children back to the CIP cohort.

在美国，甲状腺癌的发病率在过去的30年中一直在提高，原因在很大程度上是未知的。 在对5个NCI前瞻性研究的合并分析中，我们一直在研究该疾病的潜在危险因素。 该合并项目迄今为止提供了一些最有力的证据，表明肥胖症可能是甲状腺癌的危险因素，因此，肥胖率上升可能是甲状腺癌发病率上升的解释的一部分。 现在，我们正在扩大该集合项目，以包括15个欧洲和美国同伙的数据，以更详细地检查这种关系，包括与中心肥胖相关的风险以及肥胖与稀有甲状腺癌的子类型之间的关系。NCICOHORT COLHORT BMI BMI POMING POMING项目 - 我们建立了来自20千万人的生活方式风险和死亡率数据的富裕数据集，并构建了100万人的关系。 2010年发表的详细分析的结果表明，最佳BMI在20-25范围内。 我们目前正在探索腰围与所有引起死亡率之间的关联，并扩大集合项目，以查看包括甲状腺和胆囊在内的罕见癌症的癌症发病率。 这些癌症通常很难在各个同类群中研究，因为病例的数量受到限制。中国儿童和家庭同伙的癌症 - 我们正在进行两项试点研究，以测试（1）跟随（1）跟随并参与来自两个县现场的500个家庭的访谈，这些县级社区干预计划（CIP）在中期和（CIP）中均在1990年代的pedice（2）中携带了（2），并在（2）中遇到了（2），并在（2）中识别了（2），并参与了（2）的（2）。 1994 - 96年的医院，为CIP人群提供服务，并能够将这些小儿癌患者与CIP人群联系起来。 CIP社区干预计划试验是在1994 - 96年在北京东北和南部的三个大县进行的，评估了周围感受性叶酸补充剂在减少神经管缺陷方面的有效性。 在诊断期间服用叶酸补充剂的母亲的后代，神经管缺陷存在着巨大的雷神。 在过去的10年中，西方国家的病例对照流行病学研究的出版物表明，周围感受性叶酸补充剂可以减少儿科白血病的风险，以及可能在服用这些补充剂的母亲的后代中其他潜在的儿科癌症。孔口显示了与围tocectection叶酸和其他严重后代的统计关联，包括哮喘。 试点研究将试图追踪，注册和采访500个家庭，江苏省和赫比省的大腿，并将寻求确定1994年诊断为1994年诊断为1994 - 96年出生的儿童的所有儿科癌，并将这些儿童链接到CIP队伍。