Implications of the 2004-2005 Influenza Vaccine Shortage

2004-2005 年流感疫苗短缺的影响

• 批准号: 8608478
• 负责人: SRIKANTH KADIYALA
• 金额: $ 24.52万
• 依托单位: RAND CORPORATION
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-02-01 至 2016-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8608478
• 关键词: Absenteeism; Absenteeism at work; Accounting; Address; Affect; Area; Behavioral; Cause of Death; Centers for Disease Control and Prevention (U.S.); Cessation of life; Country; Data; Data Set; Data Sources; Decision Making; Dose; Drops; Failure; Health; Herd Immunity; Individual; Infection; Influenza; Influenza vaccination; Intervention; Licensure; Manufacturer Name; Marketing; Measures; Medical; Methodology; Morbidity - disease rate; Natural experiment; Outcome; Plants; Policies; Policy Maker; Population; Preventive; Production; Productivity; Public Policy; Randomized Controlled Trials; Risk Factors; Schools; Seasons; Shock; Students; Surveys; United States; Vaccinated; Vaccination; Vaccines; Variant; Work; chiron vaccine; cost; design; evidence base; experience; flu; health care service utilization; health economics; influenza virus vaccine; innovation; instrument; interest; mortality; population health; prevent; public health relevance; seasonal influenza; social; Absenteeism; Absenteeism at work; Accounting; Address; Affect; Area; Behavioral; Cause of Death; Centers for Disease Control and Prevention (U.S.); Cessation of life; Country; Data; Data Set; Data Sources; Decision Making; Dose; Drops; Failure; Health; Herd Immunity; Individual; Infection; Influenza; Influenza vaccination; Intervention; Licensure; Manufacturer Name; Marketing; Measures; Medical; Methodology; Morbidity - disease rate; Natural experiment; Outcome; Plants; Policies; Policy Maker; Population; Preventive; Production; Productivity; Public Policy; Randomized Controlled Trials; Risk Factors; Schools; Seasons; Shock; Students; Surveys; United States; Vaccinated; Vaccination; Vaccines; Variant; Work; chiron vaccine; cost; design; evidence base; experience; flu; health care service utilization; health economics; influenza virus vaccine; innovation; instrument; interest; mortality; population health; prevent; public health relevance; seasonal influenza; social

DESCRIPTION (provided by applicant): Influenza vaccination protects individuals against infection, reduces absenteeism at work and missed days of school. The 2004-2005 flu season saw a substantial reduction in influenza vaccination rates due to a shortage in the supply of the influenza vaccine. Due to failure of a Chiron production plant, compared to previous years, there was approximately a 31 million-dose shortage of the influenza vaccine and vaccination rates in the country dropped by nearly 25%. In this proposal we aim to take advantage of this natural experiment to estimate the effect of this reduction in vaccination supply on a variety of outcomes including health care utilization, mortality, work productivity and school absenteeism. Specifically, we take advantage of the fact that states that ordered vaccinations specifically from Chiron were more likely to experience a vaccine shortage than states that did not order their vaccinations from Chiron. Calculations of state level vaccination rates from the Behavioral Risk Factor Social Survey data indicate substantial cross-state variation in reductions in vaccination rates due to the shortage, with some states experiencing nearly a 40% reduction in vaccination rates while other states experienced little to no reduction. In the analyses, using unique data from the CDC on state vaccination orders specifically to Chiron, we first instrument for the reduction in state vaccination rates in the 2004-2005 flu season. We then estimate the impact of this reduction on state level measures of health care utilization, influenza mortality, work productivity and school attendance. Compared to previous work in this area, our study promises to provide comprehensive estimates of the effects of the vaccination on these outcomes since we are able to capture these outcomes for both vaccinated and unvaccinated individuals in these states. A more comprehensive accounting of the benefits of vaccination has the potential to affect policy maker decision making with respect to the utilization of the influenza vaccination to increase population health.

描述（由申请人提供）：流感疫苗接种可保护个人免受感染，减少工作中的旷工和错过的学校。由于流感疫苗的供应不足，2004-2005流感季节的流感疫苗接种率大大降低。与往年相比，由于凯龙生产厂的失败，该国流感疫苗和疫苗接种率的短缺约3100万剂量下降了近25％。 在此提案中，我们旨在利用这项自然实验，以估算疫苗接种供应减少对各种结果的影响，包括医疗保健利用，死亡率，工作生产力和学校旷工。具体而言，我们利用了以下事实：指出专门从事疫苗接种的事实 凯龙（Chiron）比未从凯龙（Chiron）下令接种疫苗的州更有可能经历疫苗短缺。行为风险因素社会调查数据的状态水平疫苗接种率的计算表明，由于短缺而导致的疫苗接种率降低的大幅变化，有些州的疫苗接种率降低了近40％，而其他州几乎没有降低。 在分析中，使用CDC专门针对Chiron的状态疫苗接种订单的独特数据，我们首先要在2004 - 2005年流感季节降低状态疫苗接种率。然后，我们估计这种减少对医疗保健利用，流感死亡率，工作生产力和学校出勤率的措施的影响。与该领域的先前工作相比，我们的研究有望对疫苗接种对这些结果的影响进行全面估计，因为我们能够为这些州的疫苗接种和未接种疫苗的人捕获这些结果。对疫苗接种益处的更全面的考虑，有可能影响政策制定者在利用流感疫苗接种方面的决策 增加人口健康。