Cortical GABA in pediatric sports concussion

皮质 GABA 在儿童运动脑震荡中的作用

• 批准号: 8661414
• 负责人: Jeffrey G Ojemann
• 金额: $ 7.18万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8661414
• 关键词: Address; Adolescent; Adult; Age; Animal Model; Area; Biological Markers; Brain; Brain Concussion; Brain Injuries; Brain Part; Brain imaging; Butyric Acids; Chemicals; Childhood; Clinical; Clinical Trials; Cognition; Cognitive; Collaborations; Control Groups; Craniocerebral Trauma; Detection; Diffusion Magnetic Resonance Imaging; Functional Magnetic Resonance Imaging; Future; Glasgow Coma Scale; Head; Image; Injury; Location; Long-Term Effects; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measurement; Measures; Medical Imaging; Memory; Metabolic; Methods; Motor Cortex; Neurotransmitters; Pediatric Hospitals; Pilot Projects; Play; Population; Prognostic Marker; Protocols documentation; Radiology Specialty; Recovery; Recruitment Activity; Relative (related person); Research; Risk; Scanning; Severities; Short-Term Memory; Specificity; Spectrum Analysis; Sports; Sports Medicine; Structure; System; Technology; Time; Trauma; Traumatic Brain Injury; Visual Cortex; Work; base; clinically relevant; cognitive function; frontal lobe; imaging modality; interest; neuroimaging; novel; programs; public health relevance; tool; Address; Adolescent; Adult; Age; Animal Model; Area; Biological Markers; Brain; Brain Concussion; Brain Injuries; Brain Part; Brain imaging; Butyric Acids; Chemicals; Childhood; Clinical; Clinical Trials; Cognition; Cognitive; Collaborations; Control Groups; Craniocerebral Trauma; Detection; Diffusion Magnetic Resonance Imaging; Functional Magnetic Resonance Imaging; Future; Glasgow Coma Scale; Head; Image; Injury; Location; Long-Term Effects; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measurement; Measures; Medical Imaging; Memory; Metabolic; Methods; Motor Cortex; Neurotransmitters; Pediatric Hospitals; Pilot Projects; Play; Population; Prognostic Marker; Protocols documentation; Radiology Specialty; Recovery; Recruitment Activity; Relative (related person); Research; Risk; Scanning; Severities; Short-Term Memory; Specificity; Spectrum Analysis; Sports; Sports Medicine; Structure; System; Technology; Time; Trauma; Traumatic Brain Injury; Visual Cortex; Work; base; clinically relevant; cognitive function; frontal lobe; imaging modality; interest; neuroimaging; novel; programs; public health relevance; tool

DESCRIPTION (provided by applicant): Pediatric concussion remains without a reliable scanning tool to image injury or guide therapies. Previous studies with MRI use methods, such as diffusion tensor imaging, functional MRI and functional connectivity MRI, that have not yet been sensitive or specific enough to be used as clinical scans. MR spectroscopy allows measures of the chemical composition in parts of the brain. Recent advances in MR spectroscopy allow for the detection of levels of neurotransmitters, including gamma-amino butyric acid (GABA) which is a widespread inhibitory transmitter. GABA function is critical for cognition and may be abnormal in trauma. Abnormal GABA levels may impair recovery in animal models of injury. Our group combines a dedicated sports concussion program, a work-in-progress collaboration with Siemens Medical Imaging group, and an advanced imaging system (3T magnet with 32 channel head coil) along with a radiology research group with expertise in pediatric neuroimaging. We will address several areas of research interest by developing and studying MR spectroscopy of GABA in a tightly defined pediatric sports concussion population, with appropriate controls. Our first aim will detect GABA levels in a clinically relevant time fram (30 min) by applying research protocols to state-of-the art clinical scanners. The second aim will be to demonstrate the difference in GABA between adolescents with concussion and those without. We will use functional MRI of working memory to target the measurement areas to make sure we are sensitive to brain areas at risk in concussion, based on the common deficits in working memory seen after concussion. In the third aim, the GABA levels will be correlated with post-concussion memory assessments and other MRI brain measures of structure and function. These results will form the basis for future clinical trials showing the utility of GABA spectroscopy in the management of pediatric concussion.

描述（由申请人提供）：小儿脑震荡仍然没有可靠的扫描工具来形象损伤或指导疗法。先前对MRI使用方法的研究，例如扩散张量成像，功能性MRI和功能连通性MRI，这些方法尚未敏感或特异性，无法用作临床扫描。 MR光谱允许测量大脑部分的化学成分。 MR光谱法的最新进展允许检测神经递质的水平，包括γ-氨基丁酸（GABA），这是一种广泛的抑制性发射器。 GABA功能对于认知至关重要，在创伤中可能是异常的。异常的GABA水平可能会损害损伤动物模型的恢复。我们的小组结合了一个专门的体育脑震荡计划，与西门子医学成像小组进行的进行工作的合作以及一个高级成像系统（带有32频道头线圈的3T磁铁）以及具有儿科神经影像学专业知识的放射学研究小组。我们将通过在严格定义的小儿运动脑震荡人群中开发和研究GABA的MR光谱法，并通过适当的控制来解决研究的几个领域。我们的第一个目标将通过将研究方案应用于最先进的临床扫描仪，在临床相关的时间FRAM（30分钟）中检测GABA水平。第二个目的是证明脑震荡青少年与没有的青少年之间的GABA差异。我们将使用工作记忆的功能性MRI来针对测量区域，以确保我们对脑震荡的常见缺陷对脑震荡的大脑区域敏感。在第三个目标中，GABA水平将与脑震荡后记忆评估以及其他MRI脑结构和功能相关。这些结果将成为未来临床试验的基础，以显示GABA光谱在小儿脑震荡治疗中的实用性。