BRAIN STRUCTURE WITH 7 TESLA MRI IN EPILEPSY

癫痫患者的脑结构与 7 特斯拉 MRI

• 批准号: 8362837
• 负责人: Thomas Reid Henry
• 金额: $ 3.03万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362837
• 关键词: Address; Adult; Brain; Cerebrum; Computer software; Data; Data Analyses; Diagnosis; Epilepsy; Fiber; Funding; Future; Grant; Image; Ipsilateral; Lesion; Limbic System; Magnetic Resonance Imaging; NMR Spectroscopy; National Center for Research Resources; Patients; Principal Investigator; Protocols documentation; Research; Research Infrastructure; Resources; Sensitivity and Specificity; Source; Structure; Testing; United States National Institutes of Health; cost; gray matter; healthy volunteer; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Many patients with epilepsy have normal brain MRI with current imaging protocols. This research protocol will address questions of whether 7 T MRI can detect lesions in epilepsy patients whose 3 T MRI was normal, and whether lesions detected with 3 T MRI will be shown to be more extensive or otherwise be better characterized with 7 T MRI. Hypothesis 1: In an epilepsy sub-group with normal cerebral 3 T MRI, cerebral structural abnormalities can be detected with 7 T MRI. Hypothesis 2: In an epilepsy sub-group with cerebral lesions on 3 T MRI, additional relevant strucutral information concerning the lesions will be provided with 7 T imaging. Hypothesis 3: In both epilepsy sub-groups (those with and without cerebral lesions on 3 T MRI), fiber tracts of the limbic system ipsilateral to the ictal onset zone will be reduced in volume compared with those of the healthy adult subjects. We will acquire structural brain MRI and DTI data with the 7 T unit of the CMRR in 10 healthy volunteers and in 20 patients with fully diagnosed, symptomatic epilepsy (who in 10 cases have normal cerebral 3 T MRI and in 10 cases have cerebral lesions on 3 T MRI), and analyze these data qualitatively and volumetrically. We will develop 7 T MRI acquisition and analysis software and protocols, and estimate 7 T MRI sensitivity and specificity in detecting cerebral gray and white matter abnormalities, so as to plan future definitive testing of Hypotheses 1-3 in a larger study

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 根据当前的成像方案，许多癫痫患者的脑部 MRI 均正常。该研究方案将解决以下问题：7 T MRI 是否可以检测 3 T MRI 正常的癫痫患者的病变，以及 3 T MRI 检测到的病变是否会显示为更广泛或用 7 T MRI 更好地表征。 假设1：在脑3 T MRI正常的癫痫亚组中，7 T MRI可以检测到脑结构异常。 假设 2：在 3 T MRI 上出现脑部病变的癫痫亚组中，7 T 成像将提供有关病变的其他相关结构信息。 假设3：在两个癫痫亚组（3T MRI 上有或没有脑损伤的患者）中，与健康成年受试者相比，发作区同侧的边缘系统纤维束的体积会减少。 我们将使用 CMRR 的 7 T 单位获取 10 名健康志愿者和 20 名完全诊断的有症状癫痫患者的结构性脑 MRI 和 DTI 数据（其中 10 例脑 3 T MRI 正常，10 例脑部病变） 3 T MRI），并定性和体积分析这些数据。我们将开发 7 T MRI 采集和分析软件和协议，并估计 7 T MRI 在检测大脑灰质和白质异常方面的敏感性和特异性，以便计划未来在更大的研究中对假设 1-3 进行确定性测试