Quantitative cardiac MRI perfusion for longitudinal studies

用于纵向研究的定量心脏 MRI 灌注

基本信息

批准号：
8705575
负责人：
EDWARD VR DIBELLA
金额：
$ 49.5万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-08-15 至 2016-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8705575
关键词：
Ablation Animal Model Area Arrhythmia Atrial Fibrillation Blood Blood flow Cardiac Cardiac ablation Cardiology Collaborations Data Data Analyses Development Diastole Disease regression Dose Electrocardiogram Estimation Techniques Evaluation Fibrosis Financial compensation Frequencies Goals Heart Heart Atrium Heart Diseases Human Image Information Resources Management Lead Left Left Atrial Function Location Longitudinal Studies Magnetic Resonance Imaging Maps Measurement Measures Methodology Methods Microspheres Monitor Motion Myocardial Myocardial perfusion Myocardium Patients Perfusion Phase Physiological Play Population Positron-Emission Tomography Process Public Health Quality of life Radial Radio Recovery Recurrence Resolution Risk Role Sampling Signal Transduction Sinus Stroke Systole Techniques Testing Time Tissues Validation Variant Ventricular Ventricular Remodeling Work base blind design flexibility heart function heart motion improved insight novel public health relevance reconstruction research clinical testing respiratory response spatiotemporal success tool

项目摘要

DESCRIPTION (provided by applicant): This work seeks to develop, evaluate and use new MRI methods for non-invasive quantitative assessment of myocardial perfusion reserve (MPR). The methods will be designed to work robustly for patients with arrhythmias or poor ECG signals. The methods will be applied along with left ventricular (LV) and left atrial (LA) function and LA fibrosis measurements to study changes due to treatment for atrial fibrillation (AF). Specific aims are (1) To design and test highly-undersampled ungated perfusion acquisitions and reconstructions. (2) To provide robust quantitative perfusion estimates by improved processing and by identifying an accurate arterial input function using methods that are widely applicable across a range of doses and acquisition types. (3) To determine the validity and repeatability of the proposed quantitative methods and the differences in perfusion and MPR measured at systole and diastole, including determining if systole or diastole is most repeatable when quantifying perfusion. (4) To determine the changes over time in perfusion reserve and cardiac function and left atrial fibrosis, after ablative treatment for AF. This will allow for determining the extent of perfusion improvement acutely due to conversion to sinus rhythm and the degree of recovery of perfusion reserve that recovers more slowly over months. These aims will be accomplished by developing methods to acquire perfusion data continuously, without a gating signal. Gating will be accomplished by analyzing the data retrospectively. Advanced reconstruction methods that include low rank and spatiotemporal constraints, and that employ compensation for respiratory and cardiac motion, will be developed and tested with the rapidly acquired self-gated perfusion sequences. An accurate arterial input function will be obtained using constrained data- driven blind estimation techniques. The accuracy of the new methods will be determined by validation in an animal model of AF, and by comparison to human studies with dynamic PET, and the repeatability of the methods will be characterized. The serial application of the methods to patients undergoing ablation therapy will then provide new information regarding changes associated with myocardial remodeling. The development and use of such accurate and repeatable measurements of perfusion in humans will accelerate evaluation of clinical therapies, and provide new tools and knowledge for the management of patients with cardiac disease.

描述（由申请人提供）：这项工作旨在开发、评估和使用新的 MRI 方法对心肌灌注储备 (MPR) 进行无创定量评估。这些方法将被设计为对心律失常或心电图信号较差的患者有效。这些方法将与左心室 (LV) 和左心房 (LA) 功能一起应用和 LA 纤维化测量，以研究心房颤动 (AF) 治疗引起的变化。具体目标是 (1) 设计和测试高度欠采样的非门控灌注采集和重建。 (2) 通过改进处理并使用广泛适用于一系列剂量和采集类型的方法识别准确的动脉输入函数，提供可靠的定量灌注估计。 (3) 确定所提出的定量方法的有效性和可重复性以及收缩期和舒张期测量的灌注和 MPR 的差异，包括确定量化灌注时收缩期或舒张期是否最具可重复性。 (4) 确定房颤消融治疗后灌注储备、心功能和左心房纤维化随时间的变化。这将允许准确确定由于转为窦性心律而导致的灌注改善程度以及灌注储备在数月内恢复较慢的恢复程度。这些目标将通过开发在没有门控信号的情况下连续采集灌注数据的方法来实现。门控将通过回顾性分析数据来完成。将使用快速获取的自门控灌注序列来开发和测试先进的重建方法，包括低阶和时空约束，以及对呼吸和心脏运动进行补偿。使用约束数据驱动的盲估计技术将获得准确的动脉输入函数。新方法的准确性将通过在 AF 动物模型中进行验证并与动态 PET 人体研究进行比较来确定，并且将表征这些方法的可重复性。这些方法对接受消融治疗的患者的连续应用将提供有关与心肌重塑相关的变化的新信息。开发和使用这种准确且可重复的人体灌注测量将加速临床治疗的评估，并为心脏病患者的治疗提供新的工具和知识。