Patient research in eosinophilic gastrointestinal diseases

嗜酸粒细胞性胃肠道疾病的患者研究

• 批准号: 8735139
• 负责人: GLENN T FURUTA
• 金额: $ 17.69万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-16 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8735139
• 关键词: Abbreviations; Abdominal Pain; Address; Adult; Affect; American; Americas; Area; Award; Beryllium; Biological Markers; Career Choice; Child; Childhood; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Clinical and Translational Science Awards; Colorado; Communities; Deglutition Disorders; Development; Development Plans; Devices; Diagnosis; Diagnostic; Diarrhea; Disease; Documentation; Education; Elements; Environment; Eosinophilia; Eosinophilic Esophagitis; Esophageal; Evaluation; FDA approved; Faculty; Fellowship; Food; Fostering; Foundations; Frequencies; Functional disorder; Funding; Gastroenterology; Gastrointestinal Diseases; Goals; Grant; Growth; Health; Hemorrhage; Hepatology; Incidence; Individual; Institutes; Intervention; Intestines; Journals; Lead; Learning; Literature; Measures; Medical; Medicine; Mentors; Mentorship; Methodology; Metric; Mid-Career Clinical Scientist Award (K24); Monitor; Natural History; Nausea and Vomiting; Outcome; Pathogenesis; Patients; Pediatric Hospitals; Phenotype; Physicians; Positioning Attribute; Productivity; Publications; Publishing; Request for Applications; Research; Research Infrastructure; Research Institute; Research Methodology; Research Personnel; Research Subjects; Research Training; Resources; Role; Scholarship; Science; Scientist; Series; Societies; Source; Supervision; Techniques; Testing; Therapeutic Intervention; Time; Training; Training Programs; Translating; Translational Research; Treatment Efficacy; United States; Universities; Vomiting; career; career development; clinical care; clinical phenotype; college; eosinophil; experience; feeding; follower of religion Jewish; gastrointestinal; improved; innovation; large bowel Crohn' s disease; medical schools; new technology; next generation; novel; nutrition; patient oriented research; programs; public health relevance; responsible research conduct; skills; success; translational study; treatment strategy

DESCRIPTION (provided by applicant): This application requests support for a mid-career investigator award for Glenn T. Furuta, MD to further develop two of the pillars of academic medicine, mentorship and patient oriented research (POR). Support from a K24 award is needed to provide protected time from clinical and administrative duties that will allow him to utilize outstanding clinical research and training resources on the Anschutz Medical Campus and the University of Colorado School of Medicine (CUSOM) for high impact POR and to nurture a pipeline of new investigators in Eosinophilic Gastrointestinal Diseases (EGIDs). He has developed a clinical and research program focusing on these diseases, the Gastrointestinal Eosinophilic Diseases Program (GEDP) to accomplish goals. At least four major impacts should result from this application including protection of the PI to; (1) Perform ongoing high quality POR that will lead to publications in high impact journals, (2) Provide pro- active mentorship to sustain a pipeline of new investigators in POR leading to publications and independent grant funding, (3) Develop novel research that will use biosamples to monitor EoE disease activity and determine novel biomarkers relevant to disease pathogenesis and (4) Define diagnostic criteria and the impact of treatments on newly defined clinical phenotypes of EGIDs. The Disease- EGIDs are an increasingly recognized group of diseases affecting children and adults characterized by nausea, vomiting, abdominal pain, dysphagia, food impaction and diarrhea that occur in conjunction with intestinal eosinophilia. Despite an increasing incidence estimated at 4 in 10,000, diagnostic criteria for one type of EGID, eosinophilic esophagitis (EoE), has only recently been defined. A heavy burden exists in defining novel EoE phenotypes, measuring disease activity and identifying therapeutic interventions especially since no FDA approved treatments exist. The Candidate- Dr. Furuta's training and mentorship experiences at three academically rich campuses, Baylor College of Medicine, Harvard Medical School and now CUSOM have allowed him to develop into a physician-scientist who is poised to further develop his skills and productivity in mentorship and POR as they relate to EGIDs. He continues to pursue a longstanding research goal of understanding eosinophil's role in GI diseases and then translating these findings into clinical care. During the course of his career, he has developed a successful track record of clinical and translational studies and spearheaded efforts to identify diagnostic criteria for one type of EGID, EoE. He has a strong track record of successful mentorship of junior investigators. As the Director of the GEDP, and Chair of the Scholarship Oversight Committee for the T32 funded Pediatric Gastroenterology Fellowship at the CUSOM and Digestive Health Institute (DHI) at Children's Hospital Colorado (CHCO), he is in the perfect position to now foster mentorship in POR to physician-scientists of outstanding promise. The Environment- Research resources at CUSOM, DHI and CHCO represent an outstanding opportunity to promote discovery and mentorship. The local Clinical Translational Science Award, termed the Colorado Clinical & Translational Sciences Institute, possesses a wide array of rich resources for mentoring and POR. T32 training programs and research units on campus provides a rich reservoir of trainees for his POR and mentorship. The GEDP's robust clinical program is an ideal source of well-defined POR subjects. The Research-Proposed research described in this K24 expands Dr. Furuta's ongoing, and develops new POR, to: determine pathogenetic mechanisms and therapeutic efficacies using biosamples and a novel device, the Esophageal String Test; define the natural history of EoE; identify diagnostic features that will provide guidance for trials; and measure the impact of treatments on novel phenotypes with feeding dysfunction. Immediate and long-term career goals 1. Short term goals- 1. Develop into an outstanding mentor, Metric-new trainees engaged in POR; 2. Develop new and complete ongoing innovative, relevant POR. Metric - grants and publications; 3. Engage junior colleagues from the CUSOM campus to publish and obtain grants. Metric-new trainees engaged in POR. 2. Long term goals-1. Provide a legacy of individuals from diverse backgrounds who will perform POR that I will help develop through pro-active mentorship; Metric - independently funded POR investigators; 2. Transform current POR within the above academic communities into a self-sustaining EGID research and clinical program. Metric - self-sustaining POR program. 3. Mentoring goals- 1. Encourage the development of trainees in POR by helping them perform hypothesis- driven research within their areas of expertise; 2. Promote careers of junior faculty by helping them to develop independently funded POR that will facilitate their recognition as leaders in their field. Key elements of the research career development plan- Described within this proposal are details of trainee selection, integration of the CTSA into POR and mentoring, active support for POR, and specific mentoring plans that include mastering the EGID literature, training in research methodology, engaging and performing POR, applying for POR funding, attending fireside chat and speaking skills series and translational research seminars. Monitoring methodology, metrics for success and impact of each element are listed.

描述（由申请人提供）：本申请要求支持医学博士Glenn T. Furuta的职业中期调查员奖，以进一步开发两个学术医学，指导和面向患者的研究（POR）的支柱。需要获得K24奖的支持，以提供受保护的时间，从临床和行政职责中，这将使他能够利用Anschutz医学校园和科罗拉多大学医学院（CUSOM）的杰出临床研究和培训资源来进行高影响力，并培育嗜酸性粒细胞性胃肠道疾病的新研究人员的管道。他制定了一项临床和研究计划，重点是这些疾病，即胃肠道嗜酸性疾病计划（GEDP）以实现目标。本申请应至少有四个重大影响，包括对PI的保护； （1）执行持续不断的高质量POR，这将导致高影响期刊的出版物，（2）提供积极的指导，以维持新的研究人员的渠道，导致出版物和独立的赠款资金，（3）开发新型研究，将使用生物样本来监控EOE疾病活动，并确定与疾病病原体和（4）在疾病病原体上和（4）诊断现象相关的新型生物标志物，并获得（4）诊断现有现象，现有现有现象现有现有现象现象现有现象，现有现有现象是现实的现象。 egids。 疾病 - 埃及是一组越来越认可的疾病，这些疾病会影响与肠道嗜酸性粒细胞的恶心，呕吐，腹痛，吞咽困难，食物症状和腹泻的特征。尽管估计有10,000分之4的发病率越来越多，但直到最近才定义了一种类型的嗜酸性嗜酸性食管炎（EOE）的诊断标准。定义新型的EOE表型，测量疾病活动并确定治疗性干预措施，尤其是因为没有FDA批准的治疗措施，就存在着沉重的负担。 候选人 - Furuta博士在三个学术丰富的校园，贝勒医学院，哈佛医学院和现在的Cusom的培训和指导经验，使他能够发展成为一名医生科学家，他们准备进一步发展他的指导技能和生产力，并与Egids有关。他继续追求长期的研究目标，以了解嗜酸性粒细胞在胃肠道疾病中的作用，然后将这些发现转化为临床护理。在他的职业生涯中，他成功地建立了临床和转化研究的成功记录，并率先努力确定一种类型的EGID EOE诊断标准。他在初级调查人员的成功指导方面拥有良好的记录。作为GEDP的主任，以及T32资助的奖学金监督委员会主席在COSOM和消化健康研究所（DHI）的儿童医院（CHCO）的儿科胃肠病学奖学金（CHCO），他现在非常适合在PORT中为PORTOSTORSHAPT，在PORT中向医生提供了良好的承诺。 CUSOM，DHI和CHCO的环境研究资源是促进发现和指导的出色机会。当地的临床转化科学奖被称为科罗拉多州临床和转化科学研究所，拥有各种各样的指导和POR资源。 T32校园内的T32培训计划和研究部门为他的POR和指导提供了丰富的学员。 GEDP的强大临床计划是定义明确的POR受试者的理想来源。 该K24中描述的研究所描述的研究扩大了Furuta博士的持续发展，并开发了新的POR，以确定使用生物样本和新型装置的致病机制和治疗效率，即食管弦测试；定义EOE的自然历史；确定将为试验提供指导的诊断功能；并通过喂养功能障碍来衡量治疗对新表型的影响。 立即和长期职业目标1。短期目标-1。成长为杰出的导师，指标的新学员，参与了POR； 2。开发新的和完整的创新性，相关的POR。指标 - 赠款和出版物； 3.与Cusom校园的初级同事互动以出版和获得赠款。公制的新学员参与了POR。 2。长期目标1。提供来自不同背景的个人的遗产，这些人将通过积极的指导来帮助我发展，这些遗产；公制 - 独立资助的POR调查员； 2.将上述学术社区内的当前POR转变为自我维持的EGID研究和临床计划。指标 - 自我维持的POR计划。 3.指导目标-1。鼓励在POR中发展受训者，通过帮助他们在其专业领域内进行假设驱动的研究； 2。通过帮助他们发展独立资助的POR来促进初级教师的职业，这将促进他们作为领导者的认可。 本提案中描述的研究职业发展计划的关键要素是培训人员选择的详细信息，将CTSA整合到POR和指导中，对POR的积极支持以及特定的指导计划，包括掌握EGID文献，研究方法学，参与度和表演POR，申请POR资助，参加Fireside聊天和讲话技能系列和翻译技能和翻译研究和翻译研究中心。列出了监视方法，列出了每个元素成功和影响的指标。