Frontiers in Macromolecular Simulations Symposium

高分子模拟前沿研讨会

基本信息

批准号：
8626415
负责人：
Jere P Segrest
金额：
$ 4万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-03-11 至 2016-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8626415
关键词：
Address Alabama Algorithms Applications Grants Biochemistry Biological Biological Sciences Biology Biomedical Engineering Biomedical Research Biophysics California Canada Caring Cell membrane Chemistry Chicago Commit Computers Databases Development Disabled Persons Electronic Mail Environment Enzymes Family Feedback Finland France Generations Genetic Transcription Goals Gray unit of radiation dose Human Genome Illinois Individual Institutes Investigation Journals Lipoproteins Medical Membrane Membrane Proteins Minority Molecular Molecular Biology Molecular Computers Molecular Genetics Molecular Models Newsletter North Carolina Pharmaceutical Preparations Pharmacology Physics Procedures Process Protein Dynamics Proteins Pump RNA Research Research Personnel Resources Ribosomal RNA Ribosomes Scientist Senior Scientist Series Signal Pathway Site Societies Structural Biochemistry Structural Biologist Structure Suggestion System Technology Texas Thinking Time Translations Universities Washington Woman Work abstracting base biological research computerized tools drug discovery falls frontier interest macromolecule medical schools meetings models and simulation molecular modeling multidisciplinary professor programs protein folding receptor simulation symposium theories transcription factor web site

项目摘要

DESCRIPTION (provided by applicant): 21st century biomedical research is being driven by the need for new drugs and procedures for solving humankind's most persistent and difficult medical problems. This research critically depends upon computer- intensive structure-based approaches to understand biological macromolecules and supramolecular assemblies in atomic detail. Progress is accelerating at a dizzying rate, and there is a critical need to promote integrative approaches driven by computational structural biologists. To help meet this challenge, our goal is to provide an environment for broadening the thinking of senior scientists, and, more important, to create a new diverse generation of theory-driven integrative scientists studying the structure and dynamics of proteins, membranes, lipoproteins, RNA and ribosomes. In this dual PI grant application, Jere Segrest (UAB) and Steve Harvey (Georgia Tech) are seeking 3 years support for an ongoing annual symposium entitled, "Frontiers in Macromolecular Simulations" that was held for the 6th time in the fall of 2009. For the past four years, the site of this symposium has alternated between UAB in Birmingham, AL and Georgia Tech in Atlanta, GA. The objective of our dual PI grant application is to hold a series of three annual conferences dedicated to fast breaking research in structure and dynamics of membranes, lipoproteins, proteins, RNA and ribosomes. Presentations at the proposed symposia will focus on theory-driven physics-based molecular modeling, simulations and experimentation. Biological research is increasingly multidisciplinary, and many experimental groups now routinely use sophisticated computational tools in their work. Our aim is to provide a venue in which application-oriented computational structural biologists will be exposed to the latest methodological advances (and provide feedback on suggested improvements), and in which experimentalists will have the opportunity to stimulate the thinking of computational biologists, both those who are primarily interested in applications, and those whose primary interest is the development of algorithms. We propose to hold the first of the three planned annual conferences for three days in March 30-April 1, 2011 at the Grand Hotel Marriott, Point Clear, Alabama. Approximately two-thirds of the platform speaker's slots will be reserved for membranes, lipoproteins and proteins and one-third for RNA and ribosomes. The two keynote speakers, Harry Gray, Professor of Chemistry, California Institute of Technology and Rachel Green, Professor of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, have agreed to join the two PIs in the organizing committee for the first conference. In addition to the keynote speakers, nine platform speakers, four women and one minority, have committed for the 2011 symposium. The second in the planned series of three conferences will be held off the Georgia Tech campus in the spring of 2012 at a still to be determined site in the State of Georgia. The final conference in the series will be held in the spring of 2013 at a neutral to be determined site in a third state, not necessarily in the Southeast.

描述（由申请人提供）：21世纪的生物医学研究是由解决人类最持久和最困难的医学问题的新药和程序的需求所驱动的。这项研究在很大程度上取决于基于计算机密集的结构方法，以了解原子细节的生物学大分子和超分子组件。进步以令人眼花of乱的速度加速，并且有迫切需要促进由计算结构生物学家驱动的综合方法。为了帮助应对这一挑战，我们的目标是提供一个环境，以扩大高级科学家的思想，更重要的是，要创建一系列多样化的理论驱动的综合科学家，研究蛋白质，膜，脂蛋白，RNA，RNA和核糖体的结构和动态。在此双PI赠款申请中，Jere Segrest（UAB）和Steve Harvey（Georgia Tech）正在寻求3年的支持，以支持2009年秋天的第6次，在过去四年中，这是uab andern and andern and andern and and andern and ol nirlande and olmand and olmingl andern and olminglance and op the emposium，在2009年秋天举行了第6次，这是“大分子模拟的前沿”。我们的双PI赠款应用的目的是举办一系列三个年度会议，致力于在膜，脂蛋白，蛋白质，RNA，RNA和核糖体的结构和动力学方面进行快速破坏研究。拟议的研讨会上的演讲将集中于理论驱动的基于物理学的分子建模，模拟和实验。生物学研究越来越多学科，许多实验组现在通常在其工作中使用复杂的计算工具。我们的目的是提供一个场所，在该场所中，面向应用的计算结构生物学家将受到最新的方法论进步（并提供有关建议改进的反馈），并且实验者将有机会刺激对计算生物学家的思想，这些思想是主要对应用程序感兴趣的人，以及那些主要兴趣的主要兴趣的人是Algorithms的发展。我们建议在3月30日至4月1日在阿拉巴马州Point Point Marriott举行三天的三天计划年度会议中的第一次。平台扬声器插槽的大约三分之二将保留给膜，脂蛋白和蛋白质，以及RNA和核糖体的三分之一。加利福尼亚理工学院化学教授哈里·格雷（Harry Gray）和分子生物学和遗传学教授雷切尔·格林（Rachel Green），约翰·霍普金斯大学医学院（Johns Hopkins University of Medicine）的化学教授哈里·格雷（Harry Gray）已同意在第一次会议的组织委员会中加入两个PIS。除了主题演讲者外，还有九位平台演讲者，四名妇女和一名少数派参加了2011年的研讨会。计划中的三个会议系列中的第二个会议将于2012年春季在佐治亚州的一个仍在确定的地点上举行。该系列的最后一次会议将于2013年春季在中立，在第三个州确定的地点，不一定在东南部。