Pacific Northwest Clinical Center for the NHLBI PETAL Network

NHLBI PETAL 网络西北太平洋临床中心

基本信息

批准号：
8705819
负责人：
EILEEN M BULGER
金额：
$ 14.5万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-06-17 至 2021-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8705819
关键词：
Accident and Emergency department Acute Lung Injury Adult Respiratory Distress Syndrome Biological Biology Caring Clinical Clinical Data Clinical Management Clinical Research Clinical Trials Clinical Trials Network Community Hospitals Computerized Medical Record Conduct Clinical Trials Critical Care Critical Illness Data Collection Databases Disease Drops Early treatment Emergency Medicine Environmental air flow Epidemiologist Epidemiology Future Goals Health Hospitals Hypoxemia Impairment Incidence Information Technology Injury Institution Intervention Investigation Lead Liquid substance Monitor Morbidity - disease rate National Heart, Lung, and Blood Institute Operative Surgical Procedures Oregon Outcome Pacific Northwest Pathogenesis Patient-Focused Outcomes Patients Prevention Protocols documentation Publications Quality Control Quality of life Randomized Controlled Clinical Trials Randomized Controlled Trials Recovery Recruitment Activity Research Research Personnel Resources Respiratory Failure Risk Safety Sampling Science Scientist Specialist Specimen Subgroup Survivors System Testing Therapy Clinical Trials Tidal Volume Trauma Ventilator Washington Work design experience high risk improved interdisciplinary approach molecular phenotype mortality multidisciplinary novel prevent protocol development public health relevance repository response screening success ward

Accident and Emergency department Acute Lung Injury Adult Respiratory Distress Syndrome Biological Biology Caring Clinical Clinical Data Clinical Management Clinical Research Clinical Trials Clinical Trials Network Community Hospitals Computerized Medical Record Conduct Clinical Trials Critical Care Critical Illness Data Collection Databases Disease Drops Early treatment Emergency Medicine Environmental air flow Epidemiologist Epidemiology Future Goals Health Hospitals Hypoxemia Impairment Incidence Information Technology Injury Institution Intervention Investigation Lead Liquid substance Monitor Morbidity - disease rate National Heart, Lung, and Blood Institute Operative Surgical Procedures Oregon Outcome Pacific Northwest Pathogenesis Patient-Focused Outcomes Patients Prevention Protocols documentation Publications Quality Control Quality of life Randomized Controlled Clinical Trials Randomized Controlled Trials Recovery Recruitment Activity Research Research Personnel Resources Respiratory Failure Risk Safety Sampling Science Scientist Specialist Specimen Subgroup Survivors System Testing Therapy Clinical Trials Tidal Volume Trauma Ventilator Washington Work design experience high risk improved interdisciplinary approach molecular phenotype mortality multidisciplinary novel prevent protocol development public health relevance repository response screening success ward

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项目摘要

DESCRIPTION (provided by applicant): The goal of the Prevention and Early Treatment of Acute Lung Injury (PETAL) Network is to develop and conduct high-quality randomized, controlled clinical trials to prevent, treat and/or improve outcomes of patients with or at risk fo acute respiratory distress syndrome (ARDS) using a multidisciplinary and collaborative approach, and to collect biologic samples and clinical data necessary to determine the molecular phenotype of disease pathogenesis, response to therapy, and recovery. The specific objective of the Pacific Northwest Clinical Center is to participate in this clinical network in orer to expand upon the work we have done through the two previous ARDS Clinical Trials Networks since 1994. ARDS is a form of hypoxemic respiratory failure that is common, often fatal, and associated with significant sequelae that have a long lasting impact on the health and quality of life of its survivors. While previous trials of pharmacologic agents have failed to decrease mortality of patients with ARDS, the first two NHLBI ARDS Networks have demonstrated that changes in ventilator and fluid management can profoundly improve patient outcome. Since the publication of the landmark study of low tidal volume ventilation in 2000, there has been a steady drop in the case fatality of ARDS. The preceding NHLBI ARDS Networks proved the hypothesis that an investigator-directed network of clinical and research centers can design and conduct investigations that would improve outcomes for patients with ARDS. By expanding the focus beyond the ICU, this new network has the potential to be even more far- reaching. The proposed Pacific Northwest Clinical Center embodies the experienced, diverse, collaborative and multidisciplinary approach that will lead to PETAL's success. We are a team of academic and community hospitals; of critical care, trauma/surgical and emergency medicine specialists; and of clinical trialists, basic scientists; epidemiologists, clinicians, and research coordinators, in both Seattle, Washington and Portland, Oregon. We believe that the opportunity to improve care and both short and long-term outcomes of critically ill patients is in the hands of this new PETAL Network. In this application, we will demonstrate why the Pacific Northwest Clinical Center will be an important part of this new Network's success.

描述（由申请人提供）：预防和早期治疗急性肺损伤（Petal）网络的目的是开发和进行高质量的随机，对照临床试验，以防止，治疗和/或改善患有或处于急性急性呼吸遇险综合征或处于风险的患者的结果，以使用多学科和协作的方法来确定多学科和协作的样本，以确定多学科和协作的样本发病机理，对治疗的反应和恢复。太平洋西北临床中心的具体目标是参与Orer的临床网络，以扩大我们自1994年以来通过之前的两个ARDS临床试验网络所做的工作。 ARDS是一种常见，通常致命的低氧呼吸衰竭形式，与重大后遗症有关，对其幸存者的健康和生活质量产生持久影响。虽然先前对药理剂的试验未能降低ARDS患者的死亡率，但前两个NHLBI ARDS网络已经证明，呼吸机和液体管理的变化可以深刻改善患者的预后。自2000年对潮汐体积通气低的地标研究发表以来，ARDS的死亡人数一直在稳步下降。先前的NHLBI ARDS网络证明了以下假设：研究人员指导的临床和研究中心网络可以设计和进行研究，从而改善ARDS患者的结果。通过将重点扩展到ICU之外，这个新网络有可能更加遥不可及。拟议的太平洋西北临床中心体现了经验丰富的，多样化，合作和多学科的方法，这将导致花瓣的成功。我们是一个学术和社区医院的团队；重症监护，外科和急诊医学专家；和临床试验者，基本科学家；西雅图，华盛顿和俄勒冈州波特兰的流行病学家，临床医生和研究协调员。我们认为，改善护理的机会以及危重患者的短期和长期成果的机会掌握在这个新的花瓣网络中。在此应用程序中，我们将证明为什么太平洋西北临床中心将成为该新网络成功的重要组成部分。