Tissue/Pathology & Immunology Core

组织/病理学

• 批准号: 8747958
• 负责人: Cornelia L Trimble
• 金额: $ 25.06万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8747958
• 关键词: Alabama; Algorithmic Software; Algorithms; Anatomic Sites; Area; Benign; Biological Markers; Biostatistics Core; Blood; Blood specimen; Carcinoma; Cells; Cervical; Clinical; Clinical Protocols; Collaborations; Colorado; Consultations; Country; Database Management Systems; Databases; Development; Diagnosis; Disasters; Disease; Documentation; Dysplasia; Enrollment; Excision; Experimental Designs; Female; Formalin; Freezing; Genital system; Gynecologic; Gynecologic Pathology; Harvest; Head and Neck Cancer; Head and neck structure; Histologic; Human; Human Papillomavirus; Image Analysis; Immune response; Immunologics; Immunology; Institution; Lesion; Liquid substance; Malignant neoplasm of cervix uteri; Microscopic; Molecular; National Cancer Institute; National Research Council; Neoplasms; Online Systems; Pathologic; Pathologist; Pathology; Patient Care; Patients; Peripheral; Photography; Practice Guidelines; Prevention strategy; Process; Protocols documentation; Recommendation; Recovery; Research Personnel; Resource Sharing; Resources; Sampling; Scanning; Site; Specimen; Study Subject; Supervision; System; Therapeutic; Time; Tissue Sample; Tissue Stains; Tissues; Translational Research; Universities; Vaccination; Work; World Health Organization; base; biobank; digital; digital imaging; encryption; experience; human tissue; neoplastic; peripheral blood; programs; screening; success; tumor

The purpose of this shared resource is to collect and distribute clinically annotated human biospecimens related to cervical cancer and HPV disease, and to provide pathologic and immunologic expertise and support for tissue-based analyses for investigators in the Johns Hopkins/University of Alabama/University of Colorado/Mount Sinai Cervical Cancer SPORE. The tissue core has been in existence since 1998, and has expanded with the support of the Cervical Cancer SPORE. To date, we have banked frozen tissue samples from 810 benign gynecologic tissues, 2,220 tumor resections, and 178 resections of preinvasive cervical HPV lesions. Longitudinally obtained exfoliated cell and peripheral blood specimens from 245 subjects enrolled in our CIN2/3 protocols have also been obtained, as well as one-time subject-matched peripheral blood samples for benign tissues (206), and from 632 tumor samples. Formalin fixed blocks are available for virtually all of these specimens. In addition, this shared resource has also banked specimens from patients enrolled in therapeutic vaccination protocols for HPV-associated squamous cancers of the head and neck. All biospecimens are harvested and banked in accordance with the National Cancer Institute¿s Best Practice Guidelines for Biorepositories. The core has been expanded to include expert pathologic and immunologic consultation to investigators, including guidance for quantitative digital image analyses-guided molecular studies of tissues. Specimens will be collected under the supervision of pathologists with expertise in gynecologic pathology, in close collaboration with clinical colleagues in these areas. Clinical information for subjects enrolled in our clinical protocols is entered into a password-protected web-based tracking system. This internal web-based system follows the recommendations of the National Research Council, and includes user authentication, encryption, audit trails, and disaster recovery. A review mechanism is in place for prioritization of distribution of requested resources to investigators within and external to the Johns Hopkins Cervical Cancer SPORE. Biosamples have been shared with collaborators at academic institutions across the country.

该共享资源的目的是收集和分发与宫颈癌和HPV疾病有关的临床注释的人类生物测量，并为约翰·霍普金斯大学/阿拉巴马大学/科罗拉多州科罗拉多大学/西班牙宫颈癌山孢子的约翰·霍普金斯大学/阿拉巴马大学约翰·霍普金斯大学/阿拉巴马大学的研究人员提供病理和免疫学专业知识和支持。自1998年以来，组织核一直存在，并在宫颈癌孢子的支持下扩展。迄今为止，我们已经从810个良性妇科组织，2,220个肿瘤切除术和178个分辨出侵入性的宫颈前HPV病变分辨出来的冷冻组织样品。还已经获得了来自CIN2/3方案中245名受试者的纵向获得的专有细胞和外周血标本，以及良性组织的一次性受试者的外围血液样本（206）和632个肿瘤样品。福尔马林固定块几乎适用于所有这些标本。此外，该共享资源还养育了招募用于HPV相关的头颈部鳞状癌症治疗方案的患者的标本。根据国家癌症研究所的最佳生物疗法指南，收集和储存所有生物测量。该核心已扩展到对研究人员的专家病理和免疫学咨询，包括对组织的定量数字图像引导的分子研究指南。标本将在病理学家的监督下与妇科病理专家的监督，并与这些领域的临床合作密切合作。我们临床方案中注册的受试者的临床信息已输入基于密码保护的基于Web的跟踪系统。该内部基于Web的系统遵循国家研究委员会的建议，包括用户身份验证，加密，审计跟踪和灾难恢复。有一种审查机制，可以优先考虑约翰·霍普金斯宫颈癌孢子内部和外部的调查人员分配所请求的资源。生物样本已与全国学术机构的合作者共享。