Tracking labor with uterine electrophysiological recordings and multi-scale model

利用子宫电生理记录和多尺度模型跟踪分娩

基本信息

批准号：
8895047
负责人：
Hari Eswaran
金额：
$ 3.62万
依托单位：
UNIV OF ARKANSAS FOR MED SCIS
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-20 至 2015-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8895047
关键词：
Accounting Action Potentials Admission activity Applied Research Arkansas Award Birth Cell model Cells Clinical Clinical Management Clinical Sciences Collection Complex Contracts Development Devices Diagnosis Discipline of obstetrics Early Diagnosis Electromagnetics Electrophysiology (science)Engineering Environment Fetal Development Fetal Research Fetus Foundations Health Healthcare Systems Hospitals Human Individual Induced Labor Intervention Investigation Knowledge Labor Onset Length of Stay Link Magnetism Measurement Medical Methodology Methods Modeling Morbidity - disease rate Mothers Myometrial National Institute of Child Health and Human Development Neurologic Newborn Infant Organ Outcome Oxytocin Patient Schedules Patients Perinatal Pharmaceutical Preparations Physicians Physiological Physiology Pregnancy Premature Birth Premature Infant Premature Labor Process Property Pseudopregnancy Published Comment Reporting Research Personnel Science Signal Transduction Smooth Muscle Source System Techniques Therapeutic Therapeutic Intervention Time Tissues Translating Translational Research United States United States National Institutes of Health Universities Uterine Contraction Uterus Washington acronyms base behavior test clinical application cost design dosage fetal improved innovation instrument magnetic field medical complication member mortality multi-scale modeling multidisciplinary myometrium pregnant pressure prevent reproductive respiratory sensor successful intervention superconducting quantum interference device tool uterine smooth muscle cell

项目摘要

DESCRIPTION (provided by applicant): Preterm birth can cause severe health problems or even be fatal for the fetus, and, also imposes significant financial burdens on health care systems. Early and reliable diagnosis is essential to the development of successful interventions to prevent preterm delivery and improve outcome. In terms of physiology, the uterus is a complex organ, and at this time, our knowledge of the physiological mechanism of the onset and propagation of uterine contractions of labor remains incomplete. The uterus is normally able to accomplish the remarkable task of maintaining an environment which suppresses uterine contractile activity and is conducive to fetal development. At term gestation however, it initiates and coordinates the individual firing of myometrial cells to produce organized contractions resulting in expulsion of the fetus. For poorly understood reasons, the onset of this coordinated activity can occur prior to term gestation with consequential birth of a premature infant. It is evident that the uterus undergoes electrophysiological changes leading to organized uterine contractions, thus providing the basis for the development of a methodology to accurately predict the onset of active labor. This proposal is a development of the combined efforts of a multidisciplinary team of members of the University of Arkansas for Medical Sciences (UAMS), University of Arkansas at Little Rock and Washington University St. Louis. All of these researchers have specialized knowledge in diverse fields of obstetrics, applied sciences and engineering relevant to the development of a synergetic environment. The need for such an effort is based on lack of tools in field of obstetrics for objective diagnosis of labor. UAMS has the world's first biomagnetic sensing system built specifically for fetal-maternal assessment. The SARA (SQUID Array for Reproductive Assessment) system consists of 151 primary superconducting sensors which detect biomagnetic fields generated in the body by various bioelectric sources including uterine muscles. The term "SQUID" is an acronym for "Superconducting Quantum Interference Device." The SARA system is completely non-invasive and permits the investigation of fetal and maternal parameters from early gestation until delivery. We have shown that SARA is capable of recording electrical activity of the uterine smooth muscles that can provide an electrophysiological signature of onset of labor. To transform it into a clinical tool we need to investigate how therapeutic interventions will alter te labor process. In order to accomplish this we propose to develop a multiscale forward electromagnetic model of contractile activity during pregnancy taking into account electrophysiological and anatomical knowledge. By combining macroscopic recordings with multi-scale modeling approach, we believe the model will not only provide a link to observed uterine electrophysiological signals but also provide useful therapeutic information for the clinical management of pregnancy.

描述（由申请人提供）：早产可能会导致严重的健康问题，甚至对胎儿造成致命，并且还会给医疗保健系统带来巨大的经济负担。早期和可靠的诊断对于制定成功的干预措施以预防早产和改善结局至关重要。从生理学角度来看，子宫是一个复杂的器官，目前，我们对临产子宫收缩的发生和传播的生理机制的认识还不完整。子宫通常能够完成维持抑制子宫收缩活动并有利于胎儿发育的环境的艰巨任务。然而，在足月妊娠时，它会启动并协调子宫肌层细胞的个体放电以产生有组织的收缩，从而导致胎儿排出。由于人们知之甚少的原因，这种协调活动可能发生在足月妊娠之前，从而导致早产儿出生。很明显，子宫经历电生理变化，导致有组织的子宫收缩，从而为开发准确预测主动分娩开始的方法提供了基础。该提案是阿肯色大学医学科学分校 (UAMS)、阿肯色大学小石城分校和华盛顿大学圣路易斯分校成员组成的多学科团队共同努力的成果。所有这些研究人员都拥有与协同环境开发相关的产科、应用科学和工程学等不同领域的专业知识。需要做出这样的努力是因为产科领域缺乏用于客观诊断分娩的工具。 UAMS 拥有世界上第一个专门用于胎儿-母体评估的生物磁传感系统。 SARA（用于生殖评估的 SQUID 阵列）系统由 151 个初级超导传感器组成，可检测包括子宫肌肉在内的各种生物电源在体内产生的生物磁场。术语“SQUID”是“超导量子干涉装置”的缩写。 SARA 系统完全无创，可以对从妊娠早期到分娩的胎儿和母体参数进行调查。我们已经证明 SARA 能够记录子宫平滑肌的电活动，从而提供临产开始时的电生理特征。为了将其转化为临床工具，我们需要研究治疗干预将如何改变分娩过程。为了实现这一目标，我们建议考虑电生理学和解剖学知识，开发怀孕期间收缩活动的多尺度正向电磁模型。通过将宏观记录与多尺度建模方法相结合，我们相信该模型不仅可以提供与观察到的子宫电生理信号的联系，还可以为妊娠的临床管理提供有用的治疗信息。