A Pooled Investigation of Prenatal Phthalate Exposure and Childhood Obesity

产前邻苯二甲酸盐暴露与儿童肥胖的综合调查

• 批准号: 8575542
• 负责人: Stephanie Engel
• 金额: $ 23.36万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-11-01 至 2015-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8575542
• 关键词: 7 year old; Accounting; Address; Affect; Age; Animals; Anthropometry; Appointment; Biological Markers; Birth; Body Composition; Body Weight Changes; Body mass index; Child; Child health care; Childhood; Chronic; Consumer Product Safety; Cross-Sectional Studies; Data; Data Analyses; Dibutyl Phthalate; Diet; Endocrine Disruptors; Endocrine disruption; Enrollment; Environment; Environmental Health; Epidemiologic Studies; Epidemiology; Exposure to; Foundations; Funding; Future; Genetic Predisposition to Disease; Goals; Growth; Growth and Development function; Investigation; Laboratories; Laboratory Research; Link; Lipids; Literature; Maternal Health; Measures; Meta-Analysis; Mission; Modification; National Health and Nutrition Examination Survey; National Institute of Environmental Health Sciences; Obesity; Outcome; Overweight; Peer Review; Prevalence; Prevention Research; Public Health; Regulation; Research Support; Resources; Risk; Role; Specimen; Surveys; Third Pregnancy Trimester; Toxic Environmental Substances; Toxicant exposure; Urine; Weight; Weight Gain; aged; base; boys; clinically relevant; cohort; data sharing; disorder prevention; energy balance; environmental chemical; exposed human population; hazard; health science research; indexing; meetings; obesity in children; obesogen; phthalates; policy implication; population based; prenatal; prenatal exposure; prospective; public health relevance; sex; urinary; waist circumference; 7 year old; Accounting; Address; Affect; Age; Animals; Anthropometry; Appointment; Biological Markers; Birth; Body Composition; Body Weight Changes; Body mass index; Child; Child health care; Childhood; Chronic; Consumer Product Safety; Cross-Sectional Studies; Data; Data Analyses; Dibutyl Phthalate; Diet; Endocrine Disruptors; Endocrine disruption; Enrollment; Environment; Environmental Health; Epidemiologic Studies; Epidemiology; Exposure to; Foundations; Funding; Future; Genetic Predisposition to Disease; Goals; Growth; Growth and Development function; Investigation; Laboratories; Laboratory Research; Link; Lipids; Literature; Maternal Health; Measures; Meta-Analysis; Mission; Modification; National Health and Nutrition Examination Survey; National Institute of Environmental Health Sciences; Obesity; Outcome; Overweight; Peer Review; Prevalence; Prevention Research; Public Health; Regulation; Research Support; Resources; Risk; Role; Specimen; Surveys; Third Pregnancy Trimester; Toxic Environmental Substances; Toxicant exposure; Urine; Weight; Weight Gain; aged; base; boys; clinically relevant; cohort; data sharing; disorder prevention; energy balance; environmental chemical; exposed human population; hazard; health science research; indexing; meetings; obesity in children; obesogen; phthalates; policy implication; population based; prenatal; prenatal exposure; prospective; public health relevance; sex; urinary; waist circumference

DESCRIPTION (provided by applicant): Over the last 20 years, we have witnessed a staggering increase in childhood obesity. The overall prevalence of obesity (defined as > 95th percentile of age- and sex-specific body mass index growth charts) has increased by 5% for children aged 2-5 and 13% for children aged 6-19. According to the most recent NHANES population-based survey, almost 1 out of 5 US children aged 6 and older now meets this definition of obese. While energy balance is a key determinant of weight change, recent evidence suggests that well-known causes of obesity, including poor diet, physical inactivity, and genetic predisposition, may not fully account for the rapid increase in obesity rates. Emerging laboratory research supports the hypothesis that common environmental chemicals may negatively impact lipid regulation in favor of weight gain. However, there have been very few epidemiological studies of environmental causes of obesity. Human exposure to phthalates is ubiquitous and a number of lines of evidence point to phthalates as possible obesogens. Starting in 1998, NIEHS and EPA jointly funded a network of Children's Environmental Health and Disease Prevention Research Centers, with the mission of addressing the role of environment in children's health. The Mount Sinai, Columbia, and Cincinnati Children's Centers each enrolled independent prospective birth cohorts, collected third trimester urine specimens, and followed children up for growth and development. Each of these Centers has already measured maternal urinary phthalate metabolites in the third trimester. We propose to pool these data in order to efficiently examine the association between maternal phthalate concentrations and longitudinal measures of adiposity from birth through age 7 years. To our knowledge, these three birth cohorts together represent the only US studies with currently available data on phthalates and growth through age 7, and constitute a rich and unique resource to efficiently address the aims of this study while providing the foundation for future pooling efforts to address the impact of environmental chemicals on children's health.

描述（由申请人提供）：在过去的20年中，我们目睹了儿童肥胖的惊人增加。肥胖症的总体患病率（定义为年龄和性别特异性体重指数增长图的> 95％）的总体患病率增加了5％，年龄在6-19岁的儿童中的儿童为13％，13％的儿童增加了13％。根据最新的基于NHANES人口的调查，现在有5名6岁及以上的美国儿童中有近1个符合肥胖的定义。尽管能量平衡是体重变化的关键决定因素，但最近的证据表明，肥胖的众所周知原因，包括饮食不良，身体不活跃和遗传易感性，可能无法完全解释肥胖率的快速增加。新兴的实验室研究支持以下假设：常见环境化学物质可能会对脂质调节产生负面影响，而对体重增加。但是，关于肥胖的环境原因的流行病学研究很少。人类对邻苯二甲酸盐的暴露是无处不在的，许多证据表明邻苯二甲酸盐可能是可能的服从者。从1998年开始，NIEHS和EPA共同资助了儿童环境健康和疾病预防研究中心网络，其使命是解决环境在儿童健康中的作用。西奈山，哥伦比亚山和辛辛那提儿童中心分别招募了独立的前瞻性出生队列，收集了三个月的尿液标本，并跟随儿童进行成长和发育。这些中心中的每个中心都已经测量了三个月中的母尿邻苯二甲酸酯代谢产物。我们建议汇总这些数据，以便有效地检查产妇邻苯二甲酸盐浓度与从出生到7岁的肥胖度的纵向测量之间的关联。据我们所知，这三个出生队列共同代表了唯一拥有有关邻苯二甲酸盐和7岁增长的数据的美国研究，并构成了丰富而独特的资源，以有效地解决本研究的目标，同时为未来的汇集工作奠定了基础，以解决环境化学物质对儿童健康的影响。