Dental Composite Materials Based on Photoinitiated Thiol-Vinyl Sulfone Reactions

基于光引发硫醇-乙烯基砜反应的牙科复合材料

• 批准号: 8729444
• 负责人: Christopher N Bowman
• 金额: $ 44.81万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8729444
• 关键词: Adhesives; Appearance; Behavior; Biocompatible; Biocompatible Materials; Biological; Chemical Structure; Clinical; Communities; Complex; Conflict (Psychology); Coupling; Dental; Dental Esthetics; Dental General Practice; Dental Materials; Dental caries; Development; Environment; Esters; Excision; Extravasation; Failure; Fatigue; Filler; Goals; Grant; In Situ; Lead; Left; Life; Mechanical Stress; Mechanics; Methacrylates; Modification; Oral; Performance; Phase; Plague; Plant Resins; Polymers; Process; Property; Reaction; Rupture; Scheme; Series; Services; Solutions; Stress; Structure; Sulfhydryl Compounds; Swelling; System; Testing; Tooth structure; absorption; base; biomaterial compatibility; chemical reaction; composite restoration; dental resin; divinyl sulfone; functional group; improved; mechanical behavior; monomer; novel; novel strategies; oral biofilm; polymerization; premature; prevent; public health relevance; restoration; restorative composite; restorative dentistry; restorative material; triethylene glycol dimethacrylate

DESCRIPTION (provided by applicant): Dental restorations represent one of the conceptually simplest biomaterials - essentially requiring the restoration of mechanical function in an aesthetically acceptable manner. Yet, despite that conceptual simplicity, an array of complex and often conflicting material, biological, curing and reaction properties necessitate a series of suboptimal solutions. Hundreds of millions of restorations are performed each year and premature failure of these restorations results in the need for a far greater number of restorations, including the occasional removal of additional healthy tooth structure. The need for simple, biocompatible, easily manipulated aesthetic dental restoratives has pushed the community towards polymeric composites that are readily reacted in situ, generally by photoinitiation, to yield a high modulus, high strength composite structure that is tooth-like in appearance. Despite the importance of these materials, the resin (i.e., the polymerizable component) phase of these systems has remained largely unchanged since its introduction several decades ago. The common use of dimethacrylate-based resins for dental restorative materials is plagued by critical problems; they do not achieve complete conversion of the methacrylates and thus leave a great deal of material that can be extracted into the oral environment. Further, these materials are prone to significant shrinkage and shrinkage stress that arises during the polymerization/curing process that is used to set the material. Thus, here, we propose a revolutionary new approach to dental materials based on the nucleophile- catalyzed thiol-vinyl sulfone network forming reaction. The proposed thiol-vinyl sulfone dental composite system will significantly improve upon the biological, chemical reaction and mechanical behavior of traditional methcrylate based composite systems. Based on exciting preliminary results that demonstrate the ability to achieve complete functional group conversion via this highly efficient, rapid reaction; appropriate mechanical behavior from the polymers formed; low shrinkage and stress; and the elimination of enzymatically reactive functional groups from the resin, we hypothesize that resins formed by this thiol-vinyl sulfone reaction represent ideal candidates as dental restorative materials. The overall aim is to develop and evaluate dental composites based on the nucleophile catalyzed thiol-vinyl sulfone Michael addition reaction that will include the development of appropriate monomers and functionalized fillers, the development of highly reactive photoinitiator systems for these resins, and the demonstration of acceptable fatigue, extractables, biocompatibility, degradation and other essential short- and long-term composite behavior. Ultimately, the overall aim is to establish these thiol-vinyl sulfone-based composites as a disruptive change in the dental composite field. We will demonstrate over the course of this grant period that these materials are capable of achieving more than a two-fold increase in service lifetime based on dramatically reduced extractables, swelling, degradation and wear in longterm, environmentally challenging testing conditions.

描述（由申请人提供）：牙科修复体是概念上最简单的生物材料之一 - 本质上是需要以美学上可接受的方式恢复机械功能。然而，尽管概念上的简单性，但一系列复杂且经常相互冲突的材料，生物学，固化和反应特性还是一系列次优的解决方案。每年进行数亿个修复体，这些修复体的过早失败导致需要大量的修复体，包括偶尔去除额外的健康牙齿结构。需要简单，生物相容性，易于操纵的美学牙齿修复，将社区推向了聚合物复合材料，这些复合材料通常是通过光启动而在原位反应的，以产生高模量，高强度的复合结构，外观类似牙齿。尽管这些材料很重要，但自几十年前引入以来，这些系统的树脂（即可聚合的组件）阶段在很大程度上保持不变。基于二甲基丙烯酸酯的树脂在牙科修复材料中的常见使用受到关键问题的困扰。它们无法实现甲基丙烯酸酯的完全转换，因此将可以提取到口腔环境中的大量材料。此外，这些材料容易承受在用于设置材料的聚合/固化过程中产生的显着收缩和收缩应力。因此，在这里，我们提出了一种革命性的新方法，以基于亲核试剂催化的硫醇 - 乙烯基磺基磺酸盐网络形成反应的牙科材料。提出的硫醇 - 乙烯基磺基牙科复合系统将显着改善基于甲基甲酯的复合系统的生物学，化学反应和机械行为。基于令人兴奋的初步结果，该结果证明了通过这种高效，快速反应实现完整功能组转换的能力。来自形成的聚合物的适当机械行为；低收缩和压力；以及从树脂中消除酶促的功能基团，我们假设由这种硫醇 - 乙烯基磺基磺极反应形成的树脂代表理想的候选物作为牙科修复材料。总体目的是基于催化催化的硫醇 - 乙烯基磺基硫磺的迈克尔添加反应来开发和评估牙科复合材料，其中包括开发适当的单体和功能化填充剂，为这些树脂的高反应性光吸剂的开发，以及可接受的疲劳，可接受的疲劳，可接受的疲劳，可接受的疲劳，可接受的疲劳，可接受的疲劳，生物相结合和其他重要的简短行为，并实现了其他优势。最终，总体目的是将这些基于硫醇 - 乙烯基磺酮的复合材料建立为牙科复合材料场的破坏性变化。我们将在整个赠款期间证明，这些材料能够基于可提取物，肿胀，降解和磨损在长期，环境挑战性的测试条件下，可以实现服务寿命的两倍以上。