Cerenkov Tomography of 4D Radiation Therapy Plans

4D 放射治疗计划的切伦科夫断层扫描

• 批准号: 8738665
• 负责人: Brian W. Pogue
• 金额: $ 18.91万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8738665
• 关键词: Algorithms; American; Area; Calibration; Complex; Data; Data Set; Development; Disease; Dose; Ensure; External Beam Radiation Therapy; Fluorescence; Four-dimensional; Funding; Future; Gel; Geometry; Goals; Hour; Image; Imagery; Individual; Intensity-Modulated Radiotherapy; Lateral; Left; Legal patent; Light; Linear Accelerator Radiotherapy Systems; Magnetic Resonance Imaging; Measures; Medical; Medicine; Methods; Monitor; Monte Carlo Method; Pathway interactions; Patients; Physics; Positron-Emission Tomography; Procedures; Process; Protocols documentation; Radiation; Radiation therapy; Recovery; Scanning; Spottings; System; Testing; Three-Dimensional Image; Time; Validation; Water; Work; base; cancer radiation therapy; cancer therapy; design; dosimetry; follow-up; image processing; imaging modality; improved; ionization; light emission; meetings; public health relevance; reconstruction; research study; tissue phantom; tomography; tool; treatment planning; validation studies

DESCRIPTION (provided by applicant): A newly discovered method for imaging radiation beam dose profiles from Cerenkov light emission will be studied and developed for real-time tomographic imaging of the advanced therapy treatment plans. Radiation therapy (RT) for cancer is one of the most technologically advanced areas of medicine today, utilizing state of the art CT, MRI, and PET imaging together with advanced treatment planning algorithms, to design patient specific delivery of radiation from a linear accelerator (LINAC). Despite this, the tools to characterize beams accuracy are extremely slow, and to date there is still no known way to visualize the beam in quickly. The importance of this new development cannot be overstated, in terms of its potential impact in the field of RT. Current procedures to measure beam dose in water tanks or tissue phantoms involve the use of ionization chambers, which are raster scanned in a 3D water tank, so that developing a 3D image of a beam would take the majority of a 24 hour day; therefore, it is rarely done. Yet, beam verification is required, and today only partial information is used in the commissioning process of new LINACs or in the verification of complex treatment plans. This newly discovered process of imaging the beam based upon the Cerenkov emission in the medium will allow instantaneous 2D imaging and very fast tomographic profiling of each beam planned. The preliminary data proving the potential of this proposal is already established, and will be followed up with a methodical development of a realization to image LINAC beams quickly with characterization of the accuracy. Systematic testing in standard medical physics water tank set ups will be completed with validation studies as outlined by the American Association of Physicists in Medicine. The accuracy of imaging advanced Intensity Modulated Radiation Therapy (IMRT) plans for cancer treatment will be studied to illustrate how imaging the planned delivery should improve accuracy. This work will be followed up through disease specific applications in future funding, following completion of this planned basic/translational period of development.

描述（由申请人提供）：将研究和开发一种新发现的用于对切伦科夫光发射的辐射束剂量分布进行成像的方法，用于先进治疗计划的实时断层扫描成像。癌症放射治疗 (RT) 是当今技术最先进的医学领域之一，利用最先进的 CT、MRI 和 PET 成像以及先进的治疗计划算法，设计来自直线加速器的针对患者的放射治疗（直线加速器）。尽管如此，表征光束精度的工具非常慢，并且迄今为止仍然没有已知的方法来快速可视化光束。就其在 RT 领域的潜在影响而言，这一新发展的重要性怎么强调都不为过。目前测量水箱或组织模型中射束剂量的程序涉及使用电离室，电离室在 3D 水箱中进行光栅扫描，因此开发射束的 3D 图像需要花费一天 24 小时的大部分时间；因此，很少这样做。然而，波束验证是必需的，并且目前在新直线加速器的调试过程或复杂治疗计划的验证中仅使用部分信息。这种新发现的基于介质中切伦科夫发射的光束成像过程将允许对每个计划的光束进行瞬时二维成像和非常快速的断层扫描分析。证明该提案潜力的初步数据已经建立，随后将有条不紊地开发实现快速对直线加速器光束进行成像并表征精度的方法。标准医学物理水箱设置的系统测试将通过美国医学物理学家协会概述的验证研究来完成。我们将研究用于癌症治疗的先进调强放射治疗 (IMRT) 计划成像的准确性，以说明计划交付的成像如何提高准确性。在完成计划的基础/转化期开发后，这项工作将通过未来资助中的疾病特定应用来跟进。