NATIONAL CHILDREN'S STUDY--PITTSBURGH-WESTMORELAND COUNTY STUDY CENTER

全国儿童学习中心--匹兹堡-威斯特摩兰县学习中心

• 批准号: 8557289
• 负责人: JANE Ann CAULEY
• 金额: $ 47.8万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-28 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8557289
• 关键词: 21 year old; Adolescent; Adult; Age; Air; Biological; Birth; Blood; Chemical Exposure; Child; Child Care; Child Development; Child health care; Clip; Cohort Studies; Collection; Computers; County; Data; Disease; Dust; Enrollment; Environment; Environmental Exposure; Fathers; Female of child bearing age; Food; Frequencies; Genes; Hair; Health; Hour; Human Milk; Individual; Infant; Lead; Location; Longitudinal Studies; Mails; Measurement; Meconium; Methods; Mothers; Nail plate; National Children' s Study; National Institute of Child Health and Human Development; Outcome; Participant; Pesticides; Phase; Pregnancy; Pregnancy Outcome; Pregnant Women; Probability Samples; Questionnaires; Sampling; Schools; Soil; Specimen; Staging; Swab; Target Populations; Telephone; Time; Tissues; Umbilical Cord Blood; United States; Urine; Vagina; Visit; Water; alcohol exposure; base; design; early childhood; environmental chemical exposure; experience; gene environment interaction; prospective; psychosocial; social; young adult

The National Children's Study (NCS) is prospective longitudinal cohort study of the individual and combined effects of environmental exposures and gene environmental interactions on child health and development in a representative sample of approximately 100,000 children born in the United States. The children will be followed from before birth until age 21. The importance and timeliness of this study are based on many factors, including past experiences demonstrating profound effects of environmental exposures, such as exposures to alcohol during pregnancy and to lead in early childhood on child health and development; the special vulnerabilities of children to environmental exposures compared to adults; known ongoing exposures, such as prevalent levels of non-persistent pesticides or hours of media exposure per day in young children; and evidence for environmental contributions or causes to high-impact conditions . The primary aim of the NCS is to investigate the separate and combined effects of environmental exposures (chemical, biological, physical, psychosocial) as well as gene-environment interactions on pregnancy outcomes, child health and development, and precursors of adult disease. Unique features of the study include its focus on environmental exposures at the earliest stages of pregnancy (as well as thereafter) and the breadth of planned exposure and outcome measurements. The NCS responds to the Congressional mandate of the Children's Health Act of 2000, that the NICHD and a consortium of federal agencies plan and conduct a longitudinal study of the impacts of environmental exposures on children. The NCS will employ a national probability sampling approach to select locations and participants for conduct of the study. The sampling design utilizes a multistage clustered approach. In the first stage, 105 locations (generally corresponding to single counties) were randomly selected from all U.S. counties. Seven of the locations serve as the initial or Vanguard Locations, participating in the pilot phase of the NCS. Because the focus of the study includes assessment of the impact of exposures that occur early in pregnancy, both pregnant women and their partners, and women of childbearing age, comprise the initial target population for enrollment. Data will be collected in combinations of face-to-face contacts and remote collection methods, e.g., telephone, computer, or mail-in questionnaires. The expected frequency of contact (face-to-face or remote) is approximately every three months through age one, every six months through age five years and annually thereafter. For a sample of children enrolled in the study, visits will also be made to child care and school settings for collection of environmental samples and observational data. Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children; blood, urine, and hair from fathers; cord blood, umbilical cord and placental tissues, and meconium collected at/around the time of delivery; vaginal swabs, and breast milk from mothers. Anticipated environmental samples include air, dust, soil, food, and water . ¿ To determine the presence or absence of long-term health effects, both harmful and helpful, on infants, children, adolescents, and young adults of specific exposures (chemical, physical, biological, and social) in their environment from preconception to adulthood. The National Children's Study (NCS) is prospective longitudinal cohort study of the individual and combined effects of environmental exposures and gene environmental interactions on child health and development in a representative sample of approximately 100,000 children born in the United States. The children will be followed from before birth until age 21. The importance and timeliness of this study are based on many factors, including past experiences demonstrating profound effects of environmental exposures, such as exposures to alcohol during pregnancy and to lead in early childhood on child health and development; the special vulnerabilities of children to environmental exposures compared to adults; known ongoing exposures, such as prevalent levels of non-persistent pesticides or hours of media exposure per day in young children; and evidence for environmental contributions or causes to high-impact conditions . The primary aim of the NCS is to investigate the separate and combined effects of environmental exposures (chemical, biological, physical, psychosocial) as well as gene-environment interactions on pregnancy outcomes, child health and development, and precursors of adult disease. Unique features of the study include its focus on environmental exposures at the earliest stages of pregnancy (as well as thereafter) and the breadth of planned exposure and outcome measurements. The NCS responds to the Congressional mandate of the Children's Health Act of 2000, that the NICHD and a consortium of federal agencies plan and conduct a longitudinal study of the impacts of environmental exposures on children. The NCS will employ a national probability sampling approach to select locations and participants for conduct of the study. The sampling design utilizes a multistage clustered approach. In the first stage, 105 locations (generally corresponding to single counties) were randomly selected from all U.S. counties. Seven of the locations serve as the initial or Vanguard Locations, participating in the pilot phase of the NCS. Because the focus of the study includes assessment of the impact of exposures that occur early in pregnancy, both pregnant women and their partners, and women of childbearing age, comprise the initial target population for enrollment. Data will be collected in combinations of face-to-face contacts and remote collection methods, e.g., telephone, computer, or mail-in questionnaires. The expected frequency of contact (face-to-face or remote) is approximately every three months through age one, every six months through age five years and annually thereafter. For a sample of children enrolled in the study, visits will also be made to child care and school settings for collection of environmental samples and observational data. Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children; blood, urine, and hair from fathers; cord blood, umbilical cord and placental tissues, and meconium collected at/around the time of delivery; vaginal swabs, and breast milk from mothers. Anticipated environmental samples include air, dust, soil, food, and water.

国家儿童研究 (NCS) 是一项前瞻性纵向队列研究，以美国出生的约 100,000 名儿童为代表样本，研究环境暴露和基因环境相互作用对儿童健康和发育的个体和综合影响。出生前至 21 岁。这项研究的重要性和及时性基于许多因素，包括过去的经验表明环境暴露的深远影响，例如怀孕期间接触酒精和儿童早期接触铅对儿童健康和发育的影响；与成人相比，儿童对环境暴露的脆弱性；已知的持续暴露，例如幼儿中非持久性农药的普遍水平或每天接触媒体的时间；以及环境影响或导致高影响条件的证据。 NCS 的目的是调查环境暴露（化学、生物、物理、社会心理）以及基因-环境相互作用对妊娠结局、儿童健康和发育以及成人疾病前兆的单独和综合影响。包括其焦点NCS 响应了 NICHD 和联邦机构联盟计划的 2000 年《儿童健康法案》的国会授权。并对环境暴露对儿童的影响进行纵向研究。 NCS 将采用全国概率抽样方法来选择进行研究的地点和参与者。抽样设计采用多阶段聚类方法，从美国所有县中随机选择 105 个地点（通常对应于单个县）。其中七个地点作为初始地点或先锋地点，参与 NCS 的试点阶段，因为该研究的重点包括评估怀孕早期发生的暴露对孕妇及其伴侣以及妇女的影响。生育年龄，包括最初的登记目标人群，将通过面对面接触和远程收集方法（例如电话、计算机或邮寄问卷（面对面或远程）相结合）的方式收集数据。对于参加研究的儿童样本，我们还将访问儿童保育机构和学校环境，以收集环境样本和观察数据。样本包括母亲和儿童的血液、尿液、指甲屑、脐带血、脐带和胎盘组织以及分娩时或分娩前后收集的胎便和乳房；预期的环境样本包括空气、灰尘、土壤、食物和水。 。确定从受孕前到成年期间在其环境中特定暴露（化学、物理、生物和社会）对婴儿、儿童、青少年和年轻人是否存在长期健康影响（有害和有益）。 国家儿童研究 (NCS) 是一项前瞻性纵向队列研究，以美国出生的约 100,000 名儿童为代表样本，研究环境暴露和基因环境相互作用对儿童健康和发育的个体影响和综合影响。出生前至 21 岁。这项研究的重要性和及时性基于许多因素，包括过去的经验表明环境暴露的深远影响，例如怀孕期间接触酒精和儿童早期接触铅对儿童健康和发育的影响；与成人相比，儿童对环境暴露的脆弱性；已知的持续暴露，例如幼儿中非持久性农药的普遍水平或每天接触媒体的时间；以及环境影响或导致高影响条件的证据。 NCS 的目的是调查环境暴露（化学、生物、物理、社会心理）以及基因-环境相互作用对妊娠结局、儿童健康和发育以及成人疾病前兆的单独和综合影响。包括其焦点NCS 响应了 NICHD 和联邦机构联盟计划的 2000 年《儿童健康法案》的国会授权。并对环境暴露对儿童的影响进行纵向研究。 NCS 将采用全国概率抽样方法来选择进行研究的地点和参与者。抽样设计采用多阶段聚类方法，从美国所有县中随机选择 105 个地点（通常对应于单个县）。其中七个地点作为初始地点或先锋地点，参与 NCS 的试点阶段，因为该研究的重点包括评估怀孕早期发生的暴露对孕妇及其伴侣以及妇女的影响。生育年龄，包括最初的登记目标人群，将通过面对面接触和远程收集方法（例如电话、计算机或邮寄问卷（面对面或远程）相结合）的方式收集数据。从一岁到一岁，每六个月一次，此后每年对参加研究的儿童样本进行一次访问，以收集环境样本和预期的生物学数据。样本包括母亲和儿童的血液、尿液、指甲屑、脐带血、脐带和胎盘组织以及分娩时或分娩前后收集的胎便和乳房；预期的环境样本包括空气、灰尘、土壤、食物和水。